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Pudong, China

Zhang W.,Sichuan Agricultural University | Zhang K.Y.,Sichuan Agricultural University | Ding X.M.,Sichuan Agricultural University | Bai S.P.,Sichuan Agricultural University | And 3 more authors.
Poultry Science | Year: 2011

To investigate the effect of canthaxanthin supplied via a maternal route on the production of both breeder hens and chickens, 270 Chinese Three-Yellow breeder hens were randomly divided into 2 groups consisting of 135 birds each (5 replicates of 27) for study. The breeder hens were fed either a basal diet or the basal diet supplemented with 6 mg of canthaxanthin/ kg for 24 wk. At the end of the 24-wk breeder experiment, all hatching eggs laid in 5 consecutive days of each group were collected and incubated. For each breeder group, 100 newly hatched chicks (5 replicates of 20) were reared under environmentally controlled conditions for 21 d. Canthaxanthin supplementation resulted in the following outcomes: an enhancement of the serum total antioxidant capacity (TAC) of breeder hens (P = 0.029), a significant increase in the yolk colorimetric score of Roche Yolk Color Fan (RYCF; P < 0.001), and a significant improvement of the antioxidant status of the egg yolk (P < 0.05). The chicks that hatched from eggs laid by breeder hens fed the canthaxanthin supplementation diet demonstrated a higher pigmentation colorimetric score of RYCF for their shank skin (P < 0.05), and the antioxidant capacity of the newly hatched chicks was significantly increased (P < 0.05). Both of these positive effects on shank skin pigmentation colorimetric score of RYCF and antioxidant capacity were observed for at least 7 d posthatching, and the chicks that hatched from canthaxanthin-enriched eggs showed a lower mortality (0 vs. 4%) during the first 21 d posthatching. These findings support the hypothesis that canthaxanthin supplementation of the maternal diet enhances the protective capacity of tissues against oxidative stress in vivo, which might be beneficial for poultry producers. © 2011 Poultry Science Association Inc.


Chen W.,Henan Agricultural University | Wang J.P.,Sichuan Agricultural University | Yan L.,DSM China Ltd | Huang Y.,Henan Agricultural University
British Poultry Science | Year: 2013

A total of 720 1-d-old broilers were used in a 28 d experiment to determine the effects of probiotic supplementation in diets with different dietary nutrient densities.2. Birds were randomly allotted to one of the 4 treatments in a 2 × 2 factorial arrangement (12 replicateswith 15 broilers per replicate) with two levels of nutrient density [high nutrient density (metabolisable energy (ME) 12.7 MJ/kg and crude protein (CP) 230.3 g/kg for 1-7 d; ME 13.2 MJ/kg and CP 220.3 g/kg for 8-28 d) or low nutrient density (ME 12.1 MJ/kg and CP 220.2 g/kg for 0-7 d; ME 12.6 MJ/kg and CP 209.8 g/kg for 8-28 d)] and 0 or 2 g/kg probiotics (1.0 × 1010 viable spores/g of Bacillus subtilis endospores and 1.0 × 109 viable spores/g of Clostridium butyricum).3. The high-nutrient-density diet increased body weight gain (BWG), feed conversion ratio (FCR), serum cholesterol and triglyceride concentration relative to the low-nutrient-density diet. High-nutrient-density diet reduced water loss ratio of breast muscle, liver and fat relative to body weight compared to low-nutrient density-diet. The inclusion of probiotics increased BWG and feed intake throughout the experiment. Dietary probiotics increased the percentage of blood lymphocytes and relative weight of spleen and bursa of Fabricius when compared to the non-probiotic treatment. The inclusion of probiotics decreased serum cholesterol and triglyceride concentrations and lightness (L*) value of breast meat compared to the non-probiotic-supplemented diet.4. In conclusion, high dietary nutrient density increased growth performance and serum cholesterol and triglyceride concentrations in broiler chickens. The inclusion of probiotics increased growth performance but reduced serum cholesterol and triglyceride concentrations. The positive effect of probiotic supplementation on growth performance was reduced by the high-nutrient-density diet during the first week of life. © 2013 © British Poultry Science Ltd.


Ren Z.,Sichuan Agricultural University | Jiang S.,Sichuan Agricultural University | Zeng Q.,Sichuan Agricultural University | Ding X.,Sichuan Agricultural University | And 8 more authors.
Journal of Animal Science and Biotechnology | Year: 2016

Background: Dietary canthaxanthin (CX), 25-hydroxycholecalciferol (25-OH-D 3) and vitamins have been widely reported to be involved in productive and reproductive performance of broiler breeders. However, limited information is available for duck breeders. In this study, a total of 1,560 Cherry Valley SM3 duck breeder females and 312 males were used to assess if the addition of CX and 25-OH-D3 could increase the performance of duck breeders under two different dietary vitamin regimens. Four diets were used under a 2 × 2 factorial arrangement with 2 kinds of vitamin premixes (REGULAR and HIGH; HIGH premix had higher levels of all vitamins except K3 than REGULAR premix), and with or without the supplementation of the mixture of CX (6 mg/kg) and 25-OH-D3 (0.069 mg/kg). The ducks were fed ad libitum with pelleted diets based on corn-soybean meal from 38 to 77 wk of age. Results: HIGH vitamin premix decreased malondialdehyde (MDA) level (P < 0.001) of egg yolk, increased hatchability of fertile eggs (P = 0.029), increased hatchability of total eggs (P = 0.029), and decreased serum protein carbonyl level (P = 0.037) of breeder males. The mixture of CX and 25-OH-D3 increased serum calcium of breeder females (P = 0.010), decreased the cracked egg rate (P = 0.001), increased the pigmentation of egg yolk (P < 0.001) and male bill (P < 0.001), and decreased MDA level of egg yolk (P < 0.001) and male serum (P = 0.034). Interactive effects were observed in cracked egg rate (P = 0.038), shell thickness (P = 0.011) and serum phosphorus (P = 0.026) of breeder females. HIGH vitamin premix together with the mixture of CX and 25-OH-D3 decreased cracked egg rate and increased shell thickness of duck breeders. Serum phosphorus was decreased in duck breeder females fed REGULAR vitamin premix without the addition of the CX and 25-OH-D3 mixture. Conclusions: Dietary HIGH vitamin premix increased antioxidant status of eggs and breeder males, and increased hatchability. The mixture of CX and 25-OH-D3 enhanced egg shell quality, and promoted pigmentation and antioxidant status of eggs and breeder males. © 2016 Ren et al.


Liu X.-W.,CAS Beijing National Laboratory for Molecular | Shi J.-L.,Sichuan Normal University | Wei J.-B.,CAS Beijing National Laboratory for Molecular | Yang C.,Peking University | And 7 more authors.
Chemical Communications | Year: 2015

The sequential construction of diversified multifunctionalized thiazole derivatives through Pd-catalyzed regioselective C-H alkenylation has been accomplished. This versatile approach provides the diversified thiazole derivatives featuring orthogonal substitution patterns at the C-2, C-4 and C-5 positions from mono-substituted (2- or 4-substituted) thiazole derivatives or even more challenging simple thiazole. © 2015 The Royal Society of Chemistry.


Jia X.W.,National Institute for Occupational Health and Poison Control | Liu Q.J.,DSM China Ltd | Zhang Y.S.,Hebei United University | Dai Y.F.,National Institute for Occupational Health and Poison Control | And 8 more authors.
Chinese Medical Journal | Year: 2014

Background Chronic exposure to n-hexane can lead to peripheral neuropathy that no effective treatment regimen could be applied presently. This study investigated whether myelin protein zero (P0) protein and its antibody could be used to distinguish n-hexane intoxication and protect workers from peripheral neuropathy. Methods We compared P0 protein and its antibody among three levels of n-hexane-exposed groups, which included 18 patients with n-hexane-induced peripheral neuropathy as case group, 120 n-hexane-exposed workers as n-hexane-exposed control group, and 147 non-hexane-exposed participants used as control group. ELISA method was applied to detect P0 protein and its antibody. Results P0 protein in serum was significantly higher in the case group and n-hexane-exposed control group in comparison with the control group (P<0.01). Compared with the n-hexane-exposed control group, the case group also had significant increase of P0 protein (P<0.01). After 6 months therapy, P0 protein was observed to decrease significantly in the case group (P<0.01). The P0 antibody in serum was significantly higher in the n-hexane-exposed control group than in the control group (P<0.01), but not significantly different between cases and controls. Conclusions P0 antibodies in serum may be a short-term effect biomarker for n-hexane exposure. P0 protein in serum may be an early effective biomarker for peripheral nerve neuropathy and its biological limit value needs investigation in the future study.

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