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Gupta A.,ICAR Vivekananda Parvatiya Krishi Anusandhan Sansthan | Gupta A.,ICAR Indian Institute of Wheat and Barley Research | Amrapali S.,ICAR Vivekananda Parvatiya Krishi Anusandhan Sansthan | Kumar M.,ICAR Vivekananda Parvatiya Krishi Anusandhan Sansthan | And 7 more authors.
National Academy Science Letters | Year: 2016

A set of 21 maize inbreds were evaluated for 29 traits for studying the Distinctness, Uniformity and Stability parameters as per the guidelines issued by the Protection of Plant Varieties and Farmers Rights Authority (PPV&FRA), India. Out of 29 traits, five traits were monomorphic, 18 traits were dimorphic, while six traits were polymorphic. The studied quantitative traits were independent and their interaction with environment as well as themselves were negligible as revealed by modified joint regression analysis. The combine over year analysis revealed that five inbreds were completely uniform, for all the MS or MG traits, while rest of the inbreds were non-uniform for 1–4 traits, but within the acceptable limit of uniformity test as per PPV&FRA guideline. Combine over year distinct analysis revealed that all the studied inbreds were found distinct to each other except VQL 1 and CM 212, which showed non-distinctiveness to each other but showed distinctiveness to other 19 inbreds. The present data can be used to develop database for inbreds and also safeguard the ownership issue. © 2015, The National Academy of Sciences, India.

Sah A.K.,Pandit Ravishankar Shukla University | Suresh P.K.,Pandit Ravishankar Shukla University | Verma V.K.,State Drug Testing Laboratory
Artificial Cells, Nanomedicine and Biotechnology | Year: 2016

The purpose of the present study was to develop loteprednol etabonate (LE) loaded poly(d,l-lactide co-glycolide) (PLGA) nanoparticles (NPs) and study their penetration profile into the excised goat cornea. In the present study, LE loaded PLGA NPs were prepared by solvent evaporation with high speed homogenization method and the penetration profile was studied using confocal laser scanning microscopy (CLSM). Rhodamine (Rd) was used as a fluorescent marker to prepare Rd-LE–PLGA-NPs. The NPs were characterized for particle size, X-ray diffraction (XRD), differential scanning calorimetry (DSC), transmission electron microscopy (TEM), drug entrapment, and permeation profile. Intense fluorescence observed across the depths of goat corneal tissue suggested an improved penetration profile of NPs. The entrapment efficiency and mean diameter of the optimized formulation (F5) were found to be 96.31 ± 1.68% and 167.6 ± 0.37 nm, respectively. These findings indicate that LE loaded PLGA NPs may serve as a potential drug carrier for ocular administration in eye disease. © 2016 Informa UK Limited, trading as Taylor & Francis Group

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