Drug Research and Development Center

Havana, Cuba

Drug Research and Development Center

Havana, Cuba
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Chanfrau J.E.R.,University of Habana | Hernandez O.D.L.,Drug Research and Development Center | Cantero O.B.,Drug Research and Development Center | Mendoza A.N.,Drug Research and Development Center | Armas M.L.,Drug Research and Development Center
Revista Cubana de Farmacia | Year: 2015

Introduction: calcium is an essential nutrient required in substantial amounts, but many diets are deficient in calcium making supplementation necessary or desirable. On the other hand, spray drying is an important technology used in the pharmaceutical industry. In this process the end-product must comply with precise quality standards. Objective: To evaluate the spray drying of calcium and magnesium citrate and to make comparison with the traditional method of drying. Methods: calcium and magnesium citrate salt was obtained at bench scale from dolomite and suspended in water in a proportion 1:10 (w/v) and spray-dried. The final batches were evaluated by chemical and technological analysis methods Results: the results showed that calcium, magnesium, citric acid and total ash content have similar concentrations regardless of the used drying method. Residual moisture content of the dried product by spray drying method was higher than that of the dried sample by traditional method. Nevertheless, all the results were below the maximum allowable limit. The physical properties of the samples for each drying method were similar except for density because the spray-dried samples showed values lower than those of traditionally dried samples. Conclusions: the results indicate that the tested spray drying conditions are suitable for drying of calcium and magnesium citrate from dolomite © 2015, Editorial Ciencias Medicas. All rights reserved.


Piloto Ferrer J.,Drug Research and Development Center | Piloto Ferrer J.,University of Habana | Stoiber T.,Institute of Molecular Biotecnology | Vizoso Parra A.,Drug Research and Development Center | And 4 more authors.
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas | Year: 2011

The main objective of anti-carcinogenic chemotherapy is to stop uncontrolled cellular proliferation. This has prompted us to begin a systematic survey of new effective inhibitors with ability to react with cytoskeletal components and arrest living, dividing cells. Even for traditional populations herbs-consuming, encouraging the use of species with chemopreventive actions could be helpful as part of life expectancy improvement strategies. Herbal products have significantly lower costs, exhibit little or no toxicity during long-term oral administration and are relatively available at large scale. Current work involved the screening of 85 extracts from Cuban medicinal plants, selected on the basis of traditional use, ethnobotanics and pharmacological information (antiparasitic, antitumour, abortive, etc.). Antitubulinic activity in the hydroalcoholics extracts was evaluated by using a modified version of the conventional turbidity assay of tubulin assembly/ disassembly. The activity limits of the news isolated antitubulin agents were thoroughly investigated. According to the presented results, the extracts displaying the highest antitubulinic activity were Tamarindus indica L., Lawsonia inermes L and Xanthium strumarium L. © 2011 The Authors.

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