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Dharmavaram A.T.,DrsSudha and Nageswara Rao Siddhartha Institute of Dental science | Nallakunta R.,Vishnu Dental College | Reddy S.R.,Vishnu Dental College | Chennoju S.K.,GSL dental college
Journal of Clinical and Diagnostic Research | Year: 2016

Introduction: Smoking is a hazardous habit which causes definite changes in the oral cavity, consequently there exist changes in the mucosa when subjected to smoking. Palatal mucosa is first to be affected. The present study determines the palatal status in reverse smokers and conventional smokers. Aim: To study and compare the clinical, cytological and histopathological changes in palatal mucosa among reverse and conventional smokers. Materials and Methods: Study sample was categorized into two groups. Group 1 comprised of 20 subjects with the habit of reverse smoking and Group 2 comprised of 20 subjects with the habit of conventional smoking. Initially, clinical appearance of the palatal mucosa was recorded, followed by a cytological smear and biopsy of the involved area among all the subjects. The findings were studied clinically, the specimens were analysed cytologically and histopathologically, and compared among the two groups. Results: The severity of clinical changes of the palatal mucosa among reverse smokers was statistically significant when compared to those of conventional smokers. There was no statistically significant difference observed in cytological staging between the groups with a p-value of 0.35. The histopathological changes in both the groups showed a significant difference with a p-value of 0.02. A significant positive correlation was observed between the clinical appearance, and cytological, histopathological changes. Conclusion: Profound clinically aggressive changes were observed in group I compared to group II. Severity of dysplastic changes have been detected in few subjects through histopathological examination irrespective of no prominent clinical and cytological changes observed among the two groups. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved. Source


Manthena S.,DrsSudha and Nageswara Rao Siddhartha Institute of Dental science | Ramoji Rao M.V.,DrsSudha and Nageswara Rao Siddhartha Institute of Dental science | Penubolu L.P.,DrsSudha and Nageswara Rao Siddhartha Institute of Dental science | Putcha M.,DrsSudha and Nageswara Rao Siddhartha Institute of Dental science | Sri Harsha A.V.N.,DrsSudha and Nageswara Rao Siddhartha Institute of Dental science
Journal of Clinical and Diagnostic Research | Year: 2015

Introduction: Deficiency of CoQ 10 was found in human inflamed gingiva and has been found to be responsible for periodontal destruction. Aim: To evaluate the effectiveness of CoQ 10 supplementation as an adjunct to scaling and rootplaning in reducing gingival inflammation and periodontal pocket depth. Materials and Methods: The study was a randomized, double-blind, controlled, parallel group design clinical trial. Thirty subjects with plaque induced gingival inflammation and having atleast three nonadjacent interproximal sites with a probing pocket depth ≥ 5mm were included in the study. The subjects were randomly divided into two groups. The test group (n=15) in which patients were given oral CoQ10 supplements after scaling and root planing and the control group (n=15) in which patients were given an oral placebo after scaling and rootplaning. The plaque index, gingival index and probing depth were recorded at baseline, 1 month and 3 months. Statistical analysis done by using Student’s paired t-test for intragroup comparison and unpaired t-test for inter-group comparison. Results: Both the groups showed marked reduction of afore mentioned periodontal parameters at one month and three months when compared to baseline. Though there was no significant difference in plaque index and probing pocket depth between the two groups at any given time period, test group showed significant difference in gingival inflammation at one month and three months when compared to control group. Conclusion: In the present study use of Coenzyme Q10 oral supplements as an adjunct to scaling and root planing showed significant reduction in gingival inflammation when compared to scaling and rootplaning alone. © Journal of Clinical and Diagnostic Research. All rights Reserved. Source

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