Philadelphia, PA, United States
Philadelphia, PA, United States

Drexel University is a private research university with three campuses in Philadelphia and one in Sacramento, California. It was founded in 1891 by Anthony J. Drexel, a noted financier and philanthropist. Drexel offers over 70 full-time undergraduate programs and accelerated degrees. At the graduate level, the university offers over 100 masters, doctoral, and professional programs, many available part-time.Drexel is best known for the cooperative education program . Drexel's co-op is regularly ranked as one of the best co-op programs in the United States. Participating students have a variety of opportunities to gain up to 18-months of paid full-time working experience before graduation. The university has a large network of more than 1,600 corporate, governmental, and non-profit partners in 28 states and 25 international locations. The employers include top ranked multinational law firms, banks, corporations, and many Fortune 500 companies, such as Goldman Sachs, Microsoft, and Procter & Gamble.Shanghai Jiao Tong University’s academic ranking of world universities ranks Drexel 401-500 and Times Higher Education World University Rankings placed Drexel among the top 200 universities in the World. In U.S. News & World Report's annual "America's Best Colleges List", the university has been ranked consistently among the "Best National Universities – Top Schools." The 2012 rankings place Drexel third in their list of “Up and Coming National Universities” for "promising and innovative changes in the areas of academics, faculty, and student life." In addition, the National Science Foundation and the 2009 Lombardi Report also ranked Drexel among the top 50 private comprehensive research universities. Drexel University ranks #45 among "Research Universities by Salary Potential" in the United States. Wikipedia.


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The present invention relates generally to compositions and methods for treating diseases and disorders caused by herpes simplex virus type 1, including herpes simplex keratitis, in a subject. In certain embodiments, the compositions of the present invention comprise an ATM inhibitor and an anti-herpetic agent. In other embodiments, the compositions comprise a Chk2 inhibitor and an anti-herpetic agent. In yet other embodiments, the compositions comprise a Chk2 inhibitor and an ATM inhibitor, and optionally an anti-herpetic agent.


Pharmaceutical compositions of the invention comprise substituted aminothiazoles derivatives having a disease-modifying action in the treatment of diseases associated with unregulated cell growth that include hepatocellular carcinoma, and infection with a hepatitis virus.


Patent
Thomas Jefferson University and Drexel University | Date: 2016-08-29

An implantable medical device having a sheath formed of a polymer material, wherein the sheath forms a reservoir attached to or around the implantable medical device, and wherein the reservoir is sealed with a biocompatible pressure responsive coating; wherein the biocompatible coating is stable for at least 7-day post implantation into a body, and can be mechanically ruptured by application of an exterior pressure generating force.


Patent
Drexel University | Date: 2016-12-01

A device and method for determining the presence or absence, or the level of, sPLA2 activity in a fluid sample. The device includes an absorbent matrix that defines a flow path for a fluid sample, a first region of the absorbent matrix for applying a fluid sample, where one of the components selected from a bioactive sPLA2 substrate and a label is dried onto or within the first region of the absorbent matrix, a second region of the absorbent matrix downstream of, and in fluid communication with, the first region for detecting an aggregated reaction product, where the other component not present in the first region is dried onto or within the second region of the absorbent matrix.


One aspect of the invention provides a method of generating ultraviolet radiation. The method includes: introducing a mixture of nitrogen gas and helium gas into a dielectric barrier discharge device including a high voltage electrode and a ground electrode separated by a gap and a dielectric; and applying suitable electricity to the high voltage electrode, thereby generating ultraviolet radiation. Another aspect of the invention provides a plasma- and ultraviolet-generating nozzle including: a dielectric barrier discharge device; and a controller programmed to control flows of gas into the dielectric barrier discharge device and application of suitable electricity to the dielectric barrier discharge device to selectively generate either plasma or ultraviolet radiation. Another aspect of the invention provides a printing system including: a motion control system; and the plasma- and ultraviolet-generating nozzle as described herein coupled to the motion control system.


Patent
Drexel University | Date: 2015-03-16

The present invention provides hydrogel-based compositions that are suitable for replacing or supplementing the nucleus pulposus in a subject. The compositions of the invention are useful for treating, ameliorating or reverting degradation of the nucleus pulposus in the subject. The present invention also provides methods of preparing and using such compositions.


A dynamic rotary traveling wave oscillator circuit includes plurality of multi-output spot-advancing blocks (MOSABs) forming a main-loop and a plurality of multi-input spot-advancing blocks (MISABs) forming a sub-loop. Depending on a desired division ratio, a connection connects blocks on the MOSABs and MISABs to create the desired division ratio.


The present invention encompasses a class of compounds known as splice modulating oligonucleotides (SMOs) that modulate pre-mRNA splicing, thereby affecting expression and functionality of a specific protein in a cell. The present invention further provides compositions and methods for modulating pre-mRNA splicing using a SMO of the invention to abrogate disease-causing mutations in a protein. Accordingly, the present invention provides compositions and methods of treating a subject at risk of, susceptible to, or having a disease, disorder, or condition associated with aberrant or unwanted target pre-mRNA expression or activity.


Patent
Drexel University | Date: 2015-02-27

One aspect of the invention provides an articulating device including: an inflatable elastic layer and a textile shell surrounding or impregnated within at least a portion of the inflatable elastic layer. The textile shell includes at least two regions having different material properties or knit patterns. The textile shell selectively constrains expansion of the inflatable elastic layer to produce controlled bending or torsion. Another aspect of the invention provides an articulating device including: an inflatable elastic layer and a textile shell surrounding or impregnated within at least a portion of the inflatable elastic layer. The textile shell has a curved profile and selectively constrains expansion of the inflatable elastic layer to produce controlled bending.


Composite Right/Left Handed (CRLH) Leaky-Wave Antennas (LWAs) are a class of radiating elements characterized by an electronically steerable radiation pattern. The design is comprised of a cascade of CRLH unit-cells populated with varactor diodes. By varying the voltage across the varactor diodes, the antenna can steer its directional beam from broadside to backward and forward end-fire directions. A CRLH Leaky-Wave Antenna for the 2.4 GHz Wi-Fi band is miniaturized by etching a Complementary Split-Ring Resonator (CSRR) underneath each CRLH unit-cell. As opposed to conventional LWA designs, the LWA layout does not require thin interdigital capacitors, significantly reducing the PCB manufacturing constraints required to achieve size reduction. The resulting antenna enables CRLH LWAs to be used not only for wireless access points, but also potentially for mobile devices.

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