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Lin A.,Drexel Plasma InstituteDrexel University200 Federal Street Suite 500Camden08103New Jersey | Han J.,Drexel Plasma InstituteDrexel University200 Federal Street Suite 500Camden08103New Jersey | Alicea Y.,Drexel Plasma InstituteDrexel University200 Federal Street Suite 500Camden08103New Jersey | Dobrynin D.,Drexel Plasma InstituteDrexel University200 Federal Street Suite 500Camden08103New Jersey | And 3 more authors.
Plasma Processes and Polymers | Year: 2015

Atmospheric pressure non-equilibrium plasmas are efficacious in killing both prokaryotic and eukaryotic cells. While the mechanism of plasma induced cell death has been thoroughly studied in prokaryotes, detailed investigation of plasma mediated eukaryotic cell death is still pending. When plasma is generated, four major components that interact with cells are produced: electric fields, radiation, charged particles, and neutral gas species. The goal of this study was to determine which of the plasma components are responsible for plasma-induced cell death by isolating and removing each from treatment. The C3H10T1/2 murine mesenchyme stem cell line was treated in six well plates, stained with Propidium Iodide to determine viability, and analyzed by image cytometry. Our results show that plasma-generated charges and reactive oxygen species are the primary contributors to cell death. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

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