Drew University is a selective coeducational private university located in Madison, New Jersey, in the United States. Drew has been nicknamed the "University in the Forest" because of the serenity of its wooded 186-acre campus when compared to the busy suburban area surrounding the school. As of 2013, 2,369 students are pursuing degrees at the university's three schools. Undergraduate tuition for the 2012–2013 academic year was US$54,200 , making Drew among the most expensive universities in New Jersey. USNews ranked Drew among the top 100 national liberal arts colleges in its 2015 rankings. .In 1867, financier and railroad tycoon Daniel Drew purchased an estate in Madison to establish a theological seminary to train candidates for ministry in the Methodist church. The seminary later expanded to offer an undergraduate liberal arts curriculum in 1928 and graduate studies in 1955. The College of Liberal Arts, serving 1,582 undergraduate students, offers strong concentrations in the natural science, social science, languages and literatures, humanities and the arts and in several interdisciplinary and multidisciplinary fields. The Drew Theological School, the third-oldest of thirteen Methodist seminaries affiliated with the United Methodist Church, currently enrolls 436 students preparing for careers in the ministry and the academic study of theology. The Caspersen School of Graduate Studies, enrolling 351 graduate students, offers masters and doctoral degrees in a variety of specialized and interdisciplinary fields.While affiliated with the Methodist faith, Drew University makes no religious demands of its students. While many of the Theological School's students and faculty are United Methodist, students of all faiths are admitted to study. The United Methodist Church's General Commission on Archives and History is located on campus and maintains an archive of Methodist records and artifacts from the nineteenth century to the present. Wikipedia.
Rustamov R.M.,Drew University
Computer Graphics Forum | Year: 2014
This paper introduces a general principle for constructing multiscale kernels on surface meshes, and presents a construction of the multiscale pre-biharmonic and multiscale biharmonic kernels. Our construction is based on an optimization problem that seeks to minimize a smoothness criterion, the Laplacian energy, subject to a sparsity inducing constraint. Namely, we use the lasso constraint, which sets an upper bound on the 11 -norm of the solution, to obtain a family of solutions parametrized by this upper-bound parameter. The interplay between sparsity and smoothness results in smooth kernels that vanish away from the diagonal. We prove that the resulting kernels have gradually changing supports, consistent behavior over partial and complete meshes, and interesting limiting behaviors (e.g. in the limit of large scales, the multiscale biharmonic kernel converges to the Green's function of the biharmonic equation); in addition, these kernels are based on intrinsic quantities and so are insensitive to isometric deformations. We show empirically that our kernels are shape-aware, are robust to noise, tessellation, and partial object, and are fast to compute. Finally, we demonstrate that the new kernels can be useful for function interpolation and shape correspondence. © 2011 The Author(s).
Campbell W.C.,Drew University
Current Pharmaceutical Biotechnology | Year: 2012
The macrocyclic lactones enjoy a position of prominence in the control of parasites, and their history may be of interest, and even of use, in an age in which the search for chemotherapeutic agents has been transformed by modern technology. Much of their history has been recorded piecemeal in a wide variety of publications. The present review provides additional detail, and offers a personal perspective on the history of ivermectin and related avermectins. Brief notes are included on the subsequent development of other macrocyclic lactones. Milbemycin preceded the avermectins as a macrocyclic lactone of agricultural importance, but was used for a different purpose. Development of the avermectins arose from the isolation, in the laboratories of the Kitasato Institute, of a novel soil-dwelling bacterium and its transmittal (in 1974) to the laboratories of Merck & Co., Inc. There it was found (in 1975) to produce a potent anthelmintic substance, which was then identified and transmuted by interdisciplinary research into an antiparasitic product. Initially the focus was on its applicability to veterinary science and animal husbandry; and after developmental research by many scientific teams, the product was introduced commercially (in 1981) for the control of endoparasitic nematodes and ectoparasitic arthropods in livestock. Subsequently, special applications in human medicine were developed, and were successfully implemented in partnership with World Health Organization and several non-governmental organizations (NGOs). © 2012 Bentham Science Publishers.
Kahn R.,University of North Carolina at Chapel Hill |
Davidson M.B.,Drew University
Diabetes Care | Year: 2014
Efforts to reduce the burden of type 2 diabetes include attempts to prevent or delay the onset of the disease. Landmark clinical trials have shown that lifestyle modification programs focused on weight loss can delay the onset of type 2 diabetes in subjects at high risk of developing the disease. Building on this knowledge, many community-based studies have attempted to replicate the trial results and, simultaneously, payers have begun to cover diabetes prevention services. This article focuses on the evidence supporting the premise that community prevention efforts will be successful. Unfortunately, no study has shown that diabetes can be delayed or prevented in a community setting, and efforts to replicate the weight loss achieved in the trials have been mostly disappointing. Furthermore, both the clinical trials and the community-based prevention studies have not shown a beneficial effect on any diabetes-related clinical outcome. While the goal of diabetes prevention is extremely important, the absence of any persuasive evidence for the effectiveness of community programs calls into question whether the use of public funds or national prevention initiatives should be supported at this time. © 2014 by the American Diabetes Association.
Ozcengiz G.,Middle East Technical University |
Demain A.L.,Drew University
Biotechnology Advances | Year: 2013
The beta-lactam antibiotics have been serving mankind for over 70. years. Despite this old age, they continue to provide health to the world population by virtue of industrial production and discoveries of new secondary metabolite molecules with useful activities. Sales of these remarkable compounds have reached over $20. billion dollars per year. They include penicillins, cephalosporins, cefoxitin, monobactams, clavulanic acid and carbapenems. Strain improvement of the penicillin-producing species of Penicillium has been truly remarkable, with present strains producing about 100,000. times more penicillin that the original Penicillium notatum of Alexander Fleming. A tremendous amount of information has been gathered on the biosynthetic enzymes involved, the pathways of biosynthesis of beta-lactams as well as their regulation, and the genomics and proteomics of the producing organisms. Modern aspects of the processes are discussed in the present review including genetics, molecular biology, metabolic engineering, genomics and proteomics. © 2012 Elsevier Inc.
Demain A.L.,Drew University
Journal of Industrial Microbiology and Biotechnology | Year: 2014
Microbes are the leading producers of useful natural products. Natural products from microbes and plants make excellent drugs. Significant portions of the microbial genomes are devoted to production of these useful secondary metabolites. A single microbe can make a number of secondary metabolites, as high as 50 compounds. The most useful products include antibiotics, anticancer agents, immunosuppressants, but products for many other applications, e.g., antivirals, anthelmintics, enzyme inhibitors, nutraceuticals, polymers, surfactants, bioherbicides, and vaccines have been commercialized. Unfortunately, due to the decrease in natural product discovery efforts, drug discovery has decreased in the past 20 years. The reasons include excessive costs for clinical trials, too short a window before the products become generics, difficulty in discovery of antibiotics against resistant organisms, and short treatment times by patients for products such as antibiotics. Despite these difficulties, technology to discover new drugs has advanced, e.g., combinatorial chemistry of natural product scaffolds, discoveries in biodiversity, genome mining, and systems biology. Of great help would be government extension of the time before products become generic. © 2013 Society for Industrial Microbiology and Biotechnology.
Agency: NSF | Branch: Continuing grant | Program: | Phase: NANO-BIOSENSING | Award Amount: 52.81K | Year: 2012
Although small organic molecules are essential to all biological systems, there remains a need for tools that allow scientists to measure the concentration of any given small molecule in a biologically relevant setting. The project leaders long-term research goal is to develop a general method to rapidly and easily monitor small molecules relevant to the study of biology and the environment. The objective of this proposal is to engineer riboswitch-based biosensors to monitor intracellular concentrations of small organic molecules. Riboswitches are naturally occurring non-coding RNA elements that act as direct sensors of diverse small molecules and can signal molecular recognition through altered protein expression. The rationale for this project is that the demonstrated plasticity of riboswitches coupled with the utility of genetic selections can form the basis of a powerful method for engineering whole-cell biosensors for small molecules. The proposed work sets out to demonstrate the utility of riboswitch-based biosensors by using a naturally occurring riboswitch to identify environmental factors that may contribute to the metabolism of an important signaling molecule, cyclic diguanylate, in Vibrio cholerae. To demonstrate how genetic selections can modify and improve natural riboswitches for use in biosensors, the V. cholerae-specific cyclic diguanylate riboswitch will also be re- engineered to generate a new riboswitch that can monitor cyclic diguanylate in any bacterial species. The potential of such a tool is immense in terms of its ability to advance the entire field of microbiology research. Finally, to demonstrate the full range and potential of this approach, a riboswitch-based biosensor for polychlorinated biphenyls will be engineered through directed evolution. The successful completion of this aim would produce a biosensor that can provide a sensitive and inexpensive means to monitor bioavailable and bioaccessible levels of a persistent organic pollutant. These models will define the precision with which riboswitch-based biosensors can be generated and will speak to their broad utility. This contribution is transformative because it is expected to provide a system that will be able to rapidly detect and report the intracellular level of virtually any cell permeant small molecule of interest.
The engineering of biosensors and the use of non-coding RNAs as research tools, moreover, present an exciting frontier for a diverse group of budding scientists. The project leader is committed to graduating scientifically literate undergraduates and motivating students to pursue life-long careers in science; this project directly addresses these career goals. Over a dozen undergraduate summer research positions will be funded over the five-year duration of the project. Students working on this project will communicate their results to the scientific community as co-authors of journal articles and as presenters at professional meetings. Student researchers will also be asked to contribute to a blog which seeks to communicate to other undergraduate and high school students what science research is and what it produces. As part of this project, authentic research experiences will be introduced into the curriculum for both majors and non-majors. In addition to providing experiential learning on-campus, the project leader is also initiating a partnership with a research-intensive institution to create off-campus research opportunities for her undergraduate students.
Agency: NSF | Branch: Standard Grant | Program: | Phase: IUSE | Award Amount: 213.32K | Year: 2015
In response to the national need to improve undergraduate STEM education, many instructors have implemented engaged student learning strategies into their courses. These pedagogies involve the development of students? process skills, such as communication, teamwork, critical thinking, and problem solving, as students learn STEM content. Because most STEM instructors have little training in how to assess student performance in these areas, the goal of this EHR: IUSE project will be to create resources that can be readily adopted to assess student process skills in a wide range of classroom types and across STEM disciplines. A secondary goal will be to create professional development tools to improve the recognition and assessment of process skills by instructors and administrators at academic institutions.
Assessment is critical to improvement of student learning in STEM courses because it provides a measure of achievement and facilitates learning. The types of assessment used by instructors telegraph to students what is valued in a course. In order to better align engaged instructional methods and assessment this project will result in the development and evaluation of (a) a set of student interaction rubrics to assess evidence of process skills in active learning classroom environments, (b) a set of student product rubrics to assess evidence of process skills in student written work, and (c) an implementation guide to assist instructors in identifying and designing tasks that elicit evidence of process skill development and to facilitate the effective implementation of the rubrics. Formative and summative evaluation questions will be addressed through ongoing assessment and revision of the rubrics; a process that will also establish their validity, reliability, and utility. Oral and written feedback will be obtained from faculty participants. They will also provide input on the usability of the implementation guidebook throughout its development. The propagation of the rubrics and implementation guide will occur through the POGIL network. The two workshops will be part of the six, annual POGIL regional meeting agendas. Results of this work will be submitted to the Journal of College Science Teaching.
Agency: NSF | Branch: Standard Grant | Program: | Phase: ATMOSPHERIC CHEMISTRY | Award Amount: 285.57K | Year: 2014
This Research in Undergraduate Institutions (RUI) project is investigating how emissions from forests and plants might react on the surfaces of the small particles in the atmosphere to change their optical properties. These changes can alter the extent to which the particles absorb or scatter solar radiation, and influence their impact on climate. The research takes place at an undergraduate institution and the experiments are being performed by an undergraduate team of researchers and one local high school science teacher under the guidance of the Principal Investigator.
The objectives of this research are to: (1) Measure the reactive uptake of biogenic VOCs on mineral substrates; (2) Quantify the impact of ?atmospheric processing? on BVOC uptake by mineral interfaces; (3) Investigate the heterogeneous oxidation of surface adsorbed BVOCs; and (4) Quantify the impact of BVOCs on the climate-relevant properties of mineral aerosol. The results of this research are useful for improving models of the formation and impact of secondary organic aerosol in the atmosphere. This project supports an active research program in physical atmospheric chemistry for undergraduate students at Drew University, a small liberal arts college with 1,600 students.
Agency: NSF | Branch: Standard Grant | Program: | Phase: GEOGRAPHY AND SPATIAL SCIENCES | Award Amount: 42.15K | Year: 2013
This project will measure, map and analyze economic forms of production, consumption, exchange, finance, and governing of common resources that pursue social and environmental sustainability associated with the broad range of activities known as the solidarity economy. Organizations participating in the solidarity economy are considered to be those that prioritize ethical commitment to cooperation, democratic participation, ecological resilience and social inclusion. Examples of organizations in this group include worker cooperatives, such as Cooperative Home Care Associates in the Bronx and Isthmus Engineering and Manufacturing in Wisconsin; consumer cooperatives, such as REI and Lancaster Farm Fresh; community land trusts, such as the Champlain Housing Trust in Vermont; credit unions; food cooperatives; and other enterprises, such as Wikipedia and local bike-sharing programs. This interdisciplinary research project will gather information about the solidarity economy in the United States, with its core hypothesis being that the U.S. solidarity economy has substantial and often unrecognized impacts on local communities in terms of increasing economic activity, employment, well-being, and overall socio-environmental sustainability. The investigators will use mixed methods from geography, economics, and other social sciences, including geographic information system-based analyses, surveys, in-depth interviews, and economic impact modeling. They expect to produce the first estimate of the spatial distribution, economic output, and locally significant influences associated with the solidarity economy in the U.S., both nationally and at local levels in Philadelphia, New York City, and Massachusetts. The project will make available a website for research, education, and participatory mapping of the solidarity economy, and it will generate a guide to enable replication of the analysis across the country by researchers, community groups, and policymakers.
This project will establish the groundwork for the solidarity economy as a new object of geographic, economic, and social research in the U.S., and it will develop methods for analysis of its nature and influence. The mapping and measurement of the role of the solidarity economy will help identify place-based strategies for local economic development. Project findings will contribute to efforts to create more socially and environmentally sustainable economic institutions that produce equity alongside jobs, goods, and services. With local community members participating in the project as researchers along with senior researchers and both graduate and undergraduate students, the project is expected to yield new insights regarding the efficacy with which solidarity economy organizations generate solutions to the pressing social problems of inequality, unemployment, and ecological unsustainability.
Drew University | Date: 2013-04-30
The invention provides methods, compositions, uses of compositions, assays and kits for modulating brown adipose tissue (BAT) in animals and patients with obesity, insulin resistance and perturbed glucose homeostasis are disclosed. Accordingly, methods, compositions, uses of compositions, and kits are useful for the amelioration of pathological conditions characterized by storage of excess energy, insulin resistance and related metabolic syndromes often associated with obesity.