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Madison, NJ, United States

Drew University is a selective coeducational private university located in Madison, New Jersey, in the United States. Drew has been nicknamed the "University in the Forest" because of the serenity of its wooded 186-acre campus when compared to the busy suburban area surrounding the school. As of 2013, 2,369 students are pursuing degrees at the university's three schools. Undergraduate tuition for the 2012–2013 academic year was US$54,200 , making Drew among the most expensive universities in New Jersey. USNews ranked Drew among the top 100 national liberal arts colleges in its 2015 rankings. .In 1867, financier and railroad tycoon Daniel Drew purchased an estate in Madison to establish a theological seminary to train candidates for ministry in the Methodist church. The seminary later expanded to offer an undergraduate liberal arts curriculum in 1928 and graduate studies in 1955. The College of Liberal Arts, serving 1,582 undergraduate students, offers strong concentrations in the natural science, social science, languages and literatures, humanities and the arts and in several interdisciplinary and multidisciplinary fields. The Drew Theological School, the third-oldest of thirteen Methodist seminaries affiliated with the United Methodist Church, currently enrolls 436 students preparing for careers in the ministry and the academic study of theology. The Caspersen School of Graduate Studies, enrolling 351 graduate students, offers masters and doctoral degrees in a variety of specialized and interdisciplinary fields.While affiliated with the Methodist faith, Drew University makes no religious demands of its students. While many of the Theological School's students and faculty are United Methodist, students of all faiths are admitted to study. The United Methodist Church's General Commission on Archives and History is located on campus and maintains an archive of Methodist records and artifacts from the nineteenth century to the present. Wikipedia.

Demain A.L.,Drew University
Applied Microbiology and Biotechnology

The principal point of this paper is that the discovery of penicillin and the development of the supporting technologies in microbiology and chemical engineering leading to its commercial scale production represent it as the medicine with the greatest impact on therapeutic outcomes. Our nomination of penicillin for the top therapeutic molecule rests on two lines of evidence concerning the impact of this event: (1) the magnitude of the therapeutic outcomes resulting from the clinical application of penicillin and the subsequent widespread use of antibiotics and (2) the technologies developed for production of penicillin, including both microbial strain selection and improvement plus chemical engineering methods responsible for successful submerged fermentation production. These became the basis for production of all subsequent antibiotics in use today. These same technologies became the model for the development and production of new types of bioproducts (i.e., anticancer agents, monoclonal antibodies, and industrial enzymes). The clinical impact of penicillin was large and immediate. By ushering in the widespread clinical use of antibiotics, penicillin was responsible for enabling the control of many infectious diseases that had previously burdened mankind, with subsequent impact on global population demographics. Moreover, the large cumulative public effect of the many new antibiotics and new bioproducts that were developed and commercialized on the basis of the science and technology after penicillin demonstrates that penicillin had the greatest therapeutic impact event of all times. © 2011 Springer-Verlag. Source

Kahn R.,University of North Carolina at Chapel Hill | Davidson M.B.,Drew University
Diabetes Care

Efforts to reduce the burden of type 2 diabetes include attempts to prevent or delay the onset of the disease. Landmark clinical trials have shown that lifestyle modification programs focused on weight loss can delay the onset of type 2 diabetes in subjects at high risk of developing the disease. Building on this knowledge, many community-based studies have attempted to replicate the trial results and, simultaneously, payers have begun to cover diabetes prevention services. This article focuses on the evidence supporting the premise that community prevention efforts will be successful. Unfortunately, no study has shown that diabetes can be delayed or prevented in a community setting, and efforts to replicate the weight loss achieved in the trials have been mostly disappointing. Furthermore, both the clinical trials and the community-based prevention studies have not shown a beneficial effect on any diabetes-related clinical outcome. While the goal of diabetes prevention is extremely important, the absence of any persuasive evidence for the effectiveness of community programs calls into question whether the use of public funds or national prevention initiatives should be supported at this time. © 2014 by the American Diabetes Association. Source

Rustamov R.M.,Drew University
Computer Graphics Forum

This paper introduces a general principle for constructing multiscale kernels on surface meshes, and presents a construction of the multiscale pre-biharmonic and multiscale biharmonic kernels. Our construction is based on an optimization problem that seeks to minimize a smoothness criterion, the Laplacian energy, subject to a sparsity inducing constraint. Namely, we use the lasso constraint, which sets an upper bound on the 11 -norm of the solution, to obtain a family of solutions parametrized by this upper-bound parameter. The interplay between sparsity and smoothness results in smooth kernels that vanish away from the diagonal. We prove that the resulting kernels have gradually changing supports, consistent behavior over partial and complete meshes, and interesting limiting behaviors (e.g. in the limit of large scales, the multiscale biharmonic kernel converges to the Green's function of the biharmonic equation); in addition, these kernels are based on intrinsic quantities and so are insensitive to isometric deformations. We show empirically that our kernels are shape-aware, are robust to noise, tessellation, and partial object, and are fast to compute. Finally, we demonstrate that the new kernels can be useful for function interpolation and shape correspondence. © 2011 The Author(s). Source

Ozcengiz G.,Middle East Technical University | Demain A.L.,Drew University
Biotechnology Advances

The beta-lactam antibiotics have been serving mankind for over 70. years. Despite this old age, they continue to provide health to the world population by virtue of industrial production and discoveries of new secondary metabolite molecules with useful activities. Sales of these remarkable compounds have reached over $20. billion dollars per year. They include penicillins, cephalosporins, cefoxitin, monobactams, clavulanic acid and carbapenems. Strain improvement of the penicillin-producing species of Penicillium has been truly remarkable, with present strains producing about 100,000. times more penicillin that the original Penicillium notatum of Alexander Fleming. A tremendous amount of information has been gathered on the biosynthetic enzymes involved, the pathways of biosynthesis of beta-lactams as well as their regulation, and the genomics and proteomics of the producing organisms. Modern aspects of the processes are discussed in the present review including genetics, molecular biology, metabolic engineering, genomics and proteomics. © 2012 Elsevier Inc. Source

Demain A.L.,Drew University
Chemistry and Biology

A group of Merck scientists in the United States and Spain have now come up with a very clever screening technique and discovered an unique antibiotic (Phillips et al.; 2011). Such discoveries are sorely needed to assist us out of the antibiotic crisis that the world is now experiencing. © 2011 Elsevier Ltd All rights reserved. Source

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