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Deshpande R.R.,Drdy Patil Dental College And Hospital | Patil V.,Drdy Patil Dental College And Hospital | Shep S.,Drdy Patil Dental College And Hospital | Chabbra R.,Drdy Patil Dental College And Hospital | And 3 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Dental caries is the most prevalent disease of hard tissues in oral cavity in humans. Salivary microflora plays a major role in the caries process. Vigorous use of various preventive and therapeutic measures to control caries led to development of multidrug resistant strains to the synthetic antimicrobial agents and increased demand for new effective and efficient alternatives with minimal side effects. Since centuries plants and their extracts have been analyzed and reported to have significant therapeutic properties. The antimicrobial efficacy of many plants is yet to be verified. In this study, the methanol and ethanol extract of Ehretia laevis and derived Compound 5 of crude ethanol extract are evaluated and compared for antimicrobial activity against salivary microflora. The salivary samples were collected from children of 6-12 years of age with moderate caries. Antibacterial assay was carried out using paper disc diffusion method in lab. The results are compared with Chlorhexidine as standard. The results depict that all the extracts have marked activity against the tested microorganisms with the Compound 5 showing larger zones of inhibition. Thus, this in vitro study supports its application as a preventive remedy for microbial diseases of hard & soft tissues in the oral cavity. Source

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