Kuppam, India
Kuppam, India

The Dravidian University , Kuppam, Chittoor district, Andhra Pradesh, India was established by the Government of Andhra Pradesh, through a Legislature Act with the initial support extended by the governments of Tamil Nadu, Karnataka and Kerala for an integrated development of Dravidian languages and culture.The university, which formally came into existence in 1997, began functioning with two departments in 1998 and has today grown into a strong institution of 20 academic departments and 6 research centres. Wikipedia.

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Subramanian N.,Dravidian University | Sundaraganesan N.,Annamalai University | Jayabharathi J.,Annamalai University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2010

Quantum chemical calculations of energies, geometrical structure and vibrational wavenumbers of 1,2-bis(3-methoxy-4-hydroxybenzylidene)hydrazine [vanillin azine (VA)] were carried out by using density functional (DFT/B3LYP) method with 6-31G(d) as basis set. The optimized geometrical parameters obtained by DFT calculations are in good agreement with single crystal XRD data. The vibrational spectral data obtained from solid phase FT-IR and FT-Raman spectra are assigned based on the results of the theoretical calculations. The observed spectra are found to be in good agreement with calculated values. The electric dipole moment (μ) and the first hyperpolarizability (β) values of the investigated molecule have been computed using ab initio quantum mechanical calculations. The calculation results also show that the VA molecule might have microscopic nonlinear optical (NLO) behavior with non-zero values. A detailed interpretation of the infrared and Raman spectra of VA was also reported. The energy and oscillator strength calculated by time-dependent density functional theory (TD-DFT) results complements with the experimental findings. The calculated HOMO and LUMO energies show that charge transfer occurs within the molecule. The theoretical NMR chemical shifts complement with experimentally measured ones. © 2010 Elsevier B.V. All rights reserved.


Charles V.,Catholic University of Peru | Kumar M.,Catholic University of Peru | Irene Kavitha S.,Dravidian University
International Journal of Production Economics | Year: 2012

The printed circuit board (PCB) assembling production process is generally optimized to ensure very low levels of errors (defects) so as to produce the higher quality product. The evaluation of efficiency of different types of PCB (cards) could help the management in identifying the quality of assembly process to work out appropriate interventions to prevent failures. This study uses the technique of data envelopment analysis to assess the efficiency of cards across all assembly units as well as within its respective assembly unit in the presence of undesirable outputs under the assumption of weak disposability. In our case, the three types of errors, viz.; machine error, manual errors and other errors that occur in the defective assembled PCBs are considered as the undesirable outputs. In-depth analysis has been carried out through jackknifing analysis to check the robustness of DEA efficiency scores. The best practice group of cards for each inefficient card has been identified which eventually facilitate the management to derive the level of undesirable outputs to be reduced and desirable output to be improved so as to achieve the level of efficiency at par with its practice group. © 2011 Elsevier B.V.


Unnamalai K.,Dravidian University
Procedia Engineering | Year: 2012

Sentiment analysis determines the attitude of a speaker or a writer with respect to some topic or the overall contextual polarity of a document. The attitude may be his or her judgment or evaluation, affective state or the intended emotional communication. It is a common practice that merchants selling products on the Web ask their customers to review the products and associated services. As e-commerce is becoming more and more popular, the number of customer reviews that a product receives grows rapidly. For a popular product, the number of reviews can be in hundreds or even thousands. This paper describes the concepts of sentiment analysis from unstructured text, looking at why they is useful and what tools and techniques are available. We will describe a variety of general rule-based and machine learning techniques, which provides some background information on the key underlying NLP processes required, and focus specifically on some of the major problems and solutions, such as detection of sarcasm, use of informal language, spam opinion detection, trustworthiness of opinion holders, and so on. We will also discuss problems associated with opinion detection in social media such as blogs, forum posts, twitter, etc. The techniques will be demonstrated with key open-source tools and applications. © 2012 Published by Elsevier Ltd.


Mann K.S.,Dravidian University | Singla J.,Singhania University | Kumar V.,Singhania University | Sidhu G.S.,G.S.S. School
Annals of Nuclear Energy | Year: 2012

To check the gamma ray shielding properties of selected low-Z building materials such as Soil-I, Soil-II, Dolomite, Gypsum, Igneous Rock and Lime Stone, some parameters of dosimetric interest have been investigated in the energy range 0.015-15 MeV. The photon interactions with the samples have been discussed mainly in terms of mass attenuation coefficient, equivalent atomic number and exposure buildup factor. From the present investigations, it has been concluded that the values of exposure buildup factors are very large in the medium energy region and Soil-I acts as best gamma ray shielding material among the selected samples. © 2012 Elsevier Ltd. All rights reserved.


Dasari S.,Dravidian University | Wudayagiri R.,Sri Venkateswara University | Valluru L.,Dravidian University
Clinica Chimica Acta | Year: 2015

Cervical cancer is a major gynecological cancer which involves uncontrolled cell division and tissue invasiveness of the female uterine cervix. With the availability of new technologies researchers have increased their efforts to develop novel biomarkers for early diagnosis, and evaluation and monitoring of therapeutic treatments. This approach will help in the development of early diagnosis and in increasing treatment efficacy with decreased recurrence. The present review explains the currently available biomarkers for cervical cancer diagnosis and prognosis. Apart from the currently available biomarkers the review also explains strategies for the development of biomarkers based on cellular and molecular approaches such as DNA, protein and other metabolic markers with suitable clinical examples. The investigations of specific proteins, enzymes and metabolites will establish more useful biomarkers for accurate detection and management of gynecological cancers especially cervical cancer. © 2015 Elsevier B.V.


Mann K.S.,Dravidian University | Mann K.S.,DAV College Kanpur | Sidhu G.S.,G.S.S.S.
Annals of Nuclear Energy | Year: 2012

G-P fitting method has been used to compute buildup factors of some low atomic number (Z) silicates for the wide energy range (0.015-15.0 MeV) up to the penetration depth of 40 mean free path. The variation of buildup factors with equivalent atomic numbers, penetration depth and incident photon energies for the selected samples has been studied. Among the observations was the inverse relationship between values of buildup factors and equivalent atomic numbers for all samples. It has been concluded that the sample with least equivalent atomic number possesses the maximum value of buildup factor. It has been verified that datolite and diopside can be used as good shielding materials. The results have been depicted graphically with some useful conclusions. © 2011 Elsevier Ltd. All rights reserved.


Dasari S.,Dravidian University | Rajendra W.,Sri Venkateswara University | Valluru L.,Dravidian University
Medical Oncology | Year: 2014

The main objective of the present study was to estimate the levels of soluble CD44 in cervical cancer patients by determining whether it consistently discriminates the carcinoma of the cervix from early or premalignant stage of the cervical cancer. Serum concentrations of sCD44s in cervical cancer patients were determined by an enzyme-linked immunosorbent assay from serum of 50 cases of cervical cancer patients and 50 cases of suspected patients with premalignant disease of cervical intraepithelial neoplasia. The sensitivity and specificity of the test for differentiating carcinoma of the cervix from premalignant stage were evaluated by plotting receiver operating characteristic (ROC) curve. Significant increase in the levels of soluble CD44 was observed in cervical cancer patients (664.80 ± 26.58 ng/ml), when compared to healthy (P < 0.001) and suspected (P < 0.05) or premalignant cases (275.19 ± 24.39 and 514.33 ± 54.57 ng/ml, respectively). High-grade squamous intraepithelial lesions, adenocarcinoma in situ and premalignance with dysplasia show significant (P < 0.001) increase in the concentration of soluble CD44 levels when compared to other types. A ROC curve was plotted and estimated the threshold value as 633.11 ng/ml. In conclusion, the data indicated an up-regulation of soluble CD44 protein which detect and differentiates the cervical carcinoma from premalignant cases with 62.6 % sensitivity. © 2014, Springer Science+Business Media New York.


Subramanyam D.,Dravidian University | Subbaiah K.C.V.,Sri Venkateswara University | Rajendra W.,Sri Venkateswara University | Lokanatha V.,Dravidian University
Experimental Oncology | Year: 2013

Aim: In the present study, the effect of chemo and radio therapies on serum trace elements content and antioxidant activity in blood serum of cervical cancer patients was evaluated. Methods: Among 104 cervical cancer patients selected for the present study, 54 and 50 patients were treated with chemo- and radiotherapy respectively. Plasma Se, Zn, Cu and some enzymatic antioxidants activities were estimated in serum before and after the treatment. Results: The decreased levels of serum trace elements, glutathione peroxidase activity and total antioxidant capacity, and increased malondialdehyde, glutathion reductase was observed in cervical cancer patients when compared to healthy controls. The increased concentration of serum Se, Zn was observed in patients treated with chemotherapy. Simultaneously there was a significant (P < 0.001) increase in glutathione peroxidase and total antioxidant capacity, and significant decrease (P < 0.05) in malondialdehyde and glutathion reductase levels in the serum of patients treated with chemotherapy compared to the patients treated with radiotherapy. Conclusion: The results demonstrated that chemotherapy but not radiotherapy results in significant increase in the trace elements levels and antioxidant activities in blood serum of cervical cancer patients. Copyright © Experimental Oncology, 2013.


Rajagopal M.,Dravidian University | Srinivas B.,Dravidian University
International Journal of Pharma and Bio Sciences | Year: 2013

Optimization of co-cultivation parameters during Agrobacterium-mediated transformation to Cissampelos pareira evaluated were bacterial density, infection period, wounding and pre-culture of explants, acetosyringone (AS) concentration and co-cultivation temperature. Optimized parameters resulted in high transformation efficiency at transient GUS expression were as follows; Agrobacterium tumefaciens growth phase of A600nm 0.17, infection period of 30 min, addition of acetosyringone (AS) in co-cultivation medium (50μM) and in bacterial growth culture (800μM) and cocultivation temperature of 25°C. Higher bacterial density resulted in more transformation efficiency, but also higher necrosis in the explants. Dilution of bacterial suspension reduced necrosis in explants and resulted in higher transformation. The transformation efficiency was increased 6 fold when the infection process was carried out with acetosyringone in co-cultivation medium (50μM) and in bacterial culture (800μM).Our studies proved that among the optimized conditions; the concentration of acetosyringone was the critical parameter during co-cultivation process in Agrobacterium mediated transformation.


Mann K.S.,Dravidian University | Kurudirek M.,Atatürk University | Sidhu G.S.,G.S.S.S.
Applied Radiation and Isotopes | Year: 2012

Dosimetric materials have been investigated in terms of calculated mass energy absorption coefficient, equivalent atomic number and KERMA (kinetic energy released per unit mass) in the energy range 0.015-15. MeV. Using analytical methodology it has verified that nylon is the best substitute dosimetric material for skin, muscle, bone and soft-tissues. Relative energy absorption buildup factors calculated by G-P fitting method confirm the findings. Nylon has been found to be good tissue substitute material for making tissue-phantoms of the biological tissues investigated. © 2011 Elsevier Ltd.

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