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Sukala P.M.,Dralmpost Graduate Institute Of Basic Medical Science | Muthusamy R.,Dralmpost Graduate Institute Of Basic Medical Science | Tamilalagan V.,National Institute of Siddha
Biomedicine (India) | Year: 2014

Introduction: Narayana chenduram (NC), a metal-based Siddha formulation, contains heavy metals. It is used to treat Parkinson's disease (PD) along with polyherbal drug Athimathura Gritham (AG). Since NC contains heavy metals it is tested for its toxicity in male albino rats.Aim: To determine the heavy metals present in NC and to study the health status of the animal treated with the drug at different dose by using hematological investigations.Materials and Methods: ICP-OES was used to determine the presence of heavy metals in NC. Hematological study was conducted in the blood of albino rats treated with the NC at acute, sub chronic dose and NC combined with AG at therapeutic dose level.Results: The metal analysis showed the presence of sulphide form of mercury and arsenic in NC. In acute toxicity study there was significant decrease in TC only but no significant changes in RBC, PCV, Hb, Neutrophils, Monocyte and Eosinophils. In sub chronic toxicity study there was significant decrease in TC and lymphocytes from day 100 and 80 onwards respectively. There was significant increase in neutrophils after 80 days of treatment. However, at the therapeutic dose up to 140 days of treatment there was no significant change in the above said parameters when combined with Athimathura Gritham.Conclusion: Eventhough NC contains heavy metals, when combined with AG at the therapeutic dose level did not show any toxic effect on hemopoietic system in male albino rats. Source


Sukala P.M.,Dralmpost Graduate Institute Of Basic Medical Science | Nirmala S.,Dralmpost Graduate Institute Of Basic Medical Science | Muthusamy R.,Dralmpost Graduate Institute Of Basic Medical Science | Tamilalagan V.,National Institute of Siddha
Biomedicine (India) | Year: 2012

Background: Narayana chenduram (NC), a metal-based Siddha formulation, contains heavy metals (mercury, cinnabar, arsenic di sulphide, arsenic tri sulphide and sulphur) and has been prepared by process of sublimation. NC is used to treat Parkinson's disease along with polyherbal drug Athimathura Gritham (AG). Since NC contains heavy metals it is tested for its toxicity in male albino rats. Methods: The heavy metals present in the NC were studied by ICPOES analysis. Biochemical study was conducted in the serum of albino rat treated with the drug at acute and sub chronic dose. Results: The ICPOES analysis showed the presence of sulphide form of mercury and arsenic in NC. In acute toxicity study there was significant increase in SGPT, SGOT, SALP, Urea and creatinine. In sub chronic toxicity study there was significant increase in above parameter after 80 days of treatment. However, at the therapeutic dose up to 140 days of treatment there was no significant change in the above said biochemical parameters when combined with Athimathura Gritham Conclusion: NC even though contain heavy metal in sulphide form, did not show any adverse toxic effect at the therapeutic dose level when treated with Athimathura Gritham. Source

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