Dr Zekai Tahir Burak Womens Health Education And Research Hospital

Ankara, Turkey

Dr Zekai Tahir Burak Womens Health Education And Research Hospital

Ankara, Turkey

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Kislal F.,Dr Zekai Tahir Burak Womens Health Education and Research Hospital | Cetinkaya S.,SAMI Health | Dilmen U.,Dr Zekai Tahir Burak Womens Health Education and Research Hospital | Yasar H.,Dr Zekai Tahir Burak Womens Health Education and Research Hospital | Tezic T.,Guven Hospital
Pediatrics International | Year: 2010

Background: The objectives of this study were to determine the cord blood thyroid-stimulating hormone (TSH) and free T4 (FT4) levels in Turkish neonates and to determine whether these variables reveal iodine deficiency. Methods: We collected 818 cords from healthy mothers at parturition and measured levels of FT4 and TSH. We also measured cord blood FT4 and TSH levels in different stages of gestation and gender. We grouped the neonates according to cord serum TSH levels, either being less (Group A) or greater (Group B) than 10 mIU/L. Group A included 589 neonates (300 girls [51%] and 289 boys [49%]) and Group B included 229 neonates (105 girls [45%] and 124 boys [55%]). Results: The percentage of subjects with cord blood TSH < 10 mIU/L and >10 mIU/L was 72% and 28%, respectively. Although cord TSH levels in Group B were greater than those in Group A (P < 0.001), cord blood FT4 levels in Group B were lower than those in Group A (P < 0.05). There was no difference between both sex in terms of birthweight and maternal age. TSH and FT4 levels did not vary according to neonate sex during gestation, except for from week 37 to 41. TSH levels of male neonates at the 41st week of gestation were higher than those of female neonates (P < 0.05). There were no effects of birthweight on TSH and FT4 levels if the neonate was lighter than 2500 g at birth. TSH levels of male neonates were higher than those of female neonates when their birthweights were <2500 g (P < 0.05). There was no significant difference in TSH levels according to birthweights in male neonates. Conclusion: Our data provide the normative data for cord blood TSH and FT4 levels in Turkish neonates and show that iodine deficiency is a still a public health problem in Turkey. These measurements can be useful for detection and verification of hypothyroidism in a screening program for congenital hypothyroidism as well as evaluation of the success of the iodination program. © 2010 Japan Pediatric Society.


PubMed | Etlik Zubeyde Hanim Womens Health Education and Research Hospital, Konya Education and Research Hospital and Dr Zekai Tahir Burak Womens Health Education And Research Hospital
Type: Journal Article | Journal: Journal of assisted reproduction and genetics | Year: 2016

In this study, we aimed to investigate serum and follicular fluid amyloid A protein levels in non-obese non-hyperandrogenic patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF) and IVF outcome.A total of 81 patients undergoing IVF treatment, 41 patients diagnosed as PCOS according to the Rotterdam criteria (group I) and 40 patients with the etiology of male factor infertility (group II), were included in the study. On the day of oocyte pickup, serum and follicular fluid samples were collected from all patients.Serum E2 level on the day of hCG (2849.93541.54 vs. 2494.28712.98) and total number of retrieved oocytes (13.733.57 vs. 10.534.07) were significantly higher in group I when compared to group II (p<0.05). However, number of mature oocytes, fertilization rate, and clinical pregnancy rate did not differ (p>0.05). No significant difference was found between two groups regarding the serum and follicular fluid amyloid A protein levels on the day of oocyte retrieval (p>0.05).


Topcu H.O.,Dr Zekai Tahir Burak Womens Health Education and Research Hospital | Guzel A.I.,Dr Zekai Tahir Burak Womens Health Education and Research Hospital | Ozer I.,Dr Zekai Tahir Burak Womens Health Education and Research Hospital | Kokanali M.K.,Dr Zekai Tahir Burak Womens Health Education and Research Hospital | And 3 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2014

Purpose: To compare the diagnostic accuracy of the neutrophil/lymphocyte ratio (NLR) with the platelet/lymphocyte ratio (PLR) in predicting malignancy of pelvic masses which are pre-operatively malignant suspicious. Materials and Methods: In this retrospective study we evaluated the clinical features of patients with ovarian masses which had pre-operatively been considered suspicious for malignancy. The patients whose intraoperative frozen sections were malign were classified as the study group, while those who had benign masses were the control group. Data recorded were age of the patient, diameter of the mass, pre-operative serum Ca 125 levels, platelet count, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio. Results: There was statistically significantly difference between the groups in terms of age, diameter of the mass, serum Ca 125 levels, platelet number and platelet/lymphocyte ratio. Mean neutrophil/lymphocyte ratios showed no difference between the groups. ROC curve analysis showed that age, serum Ca 125 levels, platelet number and PLR were discriminative markers in predicting malignancy in adnexal masses. Conclusions: According to the current study, serum Ca 125 levels, pre-operative platelet number and PLR may be good prognostic factors, while NLR is an ineffective marker in predicting the malignant characteristics of a pelvic mass.


PubMed | Kayseri Memorial Private Hospital, Ankara Ataturk Training and Research Hospital, Dr Zekai Tahir Burak Womens Health Education and Research Hospital and Kayseri Training and Research Hospital
Type: | Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians | Year: 2016

To evaluate the relationship between entanglement of umbilical cord around the fetal neck and adverse perinatal outcomes.In this prospective cohort study, perinatal outcomes of 218 pregnancies complicated with nuchal cord (NC) (study group) were compared with 190 uncomplicated pregnancies (control group). Main outcome measures were umbilical cord pH values, APGAR scores and cesarean section (C/S) rates. Fetal distress was stated as an abnormal heart rate pattern on electronic fetal heart monitorization.There were no statistically significant differences in maternal demographic and obstetric features, between groups. There were no statistically significant differences regarding C/S rates between groups, even though fetal distress was significantly the leading indication for cesarean delivery, in the study group (p=0.021). The number of entanglement was significantly related with fetal distress (p<0.001). There were no statistically significant differences in umbilical cord gas values, one-minute and five-minute APGAR scores between the groups. Furthermore, there was a significant male dominance in the study group (p=0.014) and also, amniotic fluid indexes (AFI) were significantly higher in this group (p=0.002).This study demonstrated that, entanglement of umbilical cord around the fetal neck or NC is not related with adverse perinatal outcomes such as acidosis and low APGAR scores. So that, a targeted care on NC via ultrasound during labor, is not an essential part of the examination.


Yesilyurt H.,Dr Zekai Tahir Burak Womens Health Education and Research Hospital | Tokmak A.,Dr Zekai Tahir Burak Womens Health Education and Research Hospital | Guzel A.I.,Dr Zekai Tahir Burak Womens Health Education and Research Hospital | Simsek H.S.,Dr Zekai Tahir Burak Womens Health Education and Research Hospital | And 3 more authors.
Asian Pacific journal of cancer prevention : APJCP | Year: 2014

BACKGROUND: To evaluate factors for predicting the granulosa cell tumor of the ovary (GCTO) pre-operatively.MATERIALS AND METHODS: This retrospective designed study was conducted on 34 women with GCTO as the study group and 76 women with benign ovarian cysts as the control group. Data were recorded from the hospital database and included age, body mass index (BMI), parity, serum estradiol (E2) levels, diameter of the mass, ultrasonographic features, serum CA125 level, risk of malignancy index (RMI), duration of menopause, postoperative histopathology result, and the neutrophil/lymphocyte ratio (NLR).RESULTS: The demographic parameters showed no statistically significant difference between the groups. Preoperative diameter of the mass, CA125, duration of menopause, and neutrophil/lymphocyte ratio were significantly different between the groups. ROC curve analysis demonstrated that diameter of the mass, serum estradiol and Ca125 levels, RMI and NLR may be discriminative factors in predicting GCTO preoperatively.CONCLUSIONS: In conclusion, we think that a careful preoperative workshop including diameter of the mass, serum estradiol (E2) and Ca125 levels, RMI and NLR may predict GCTO and may prevent incomplete approaches.


Karaer A.,Dr Zekai Tahir Burak Womens Health Education And Research Hospital | Mert I.,Dr Zekai Tahir Burak Womens Health Education And Research Hospital | Cavkaytar S.,Dr Zekai Tahir Burak Womens Health Education And Research Hospital | Batioglu S.,Dr Zekai Tahir Burak Womens Health Education And Research Hospital
European Journal of Contraception and Reproductive Health Care | Year: 2013

Objectives To investigate the association between selected sexually transmitted infections (STIs) and the later occurrence of ectopic pregnancy. Methods A total of 125 women with ectopic pregnancy and 125 pregnant controls were recruited between January 2003 and February 2005 at Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, in Ankara, Turkey. Enzyme-linked immunosorbent assay was used to determine the prevalence of serum antibodies to Chlamydia (C.) trachomatis and to Herpes simplex virus (HSV)-2 IgG and, indirect immunofluorescence test was used to determine the prevalence of serum antibodies to Mycoplasma (M.) hominis and Ureaplasma (U.) urealyticum. Results The prevalence of C. trachomatis Ig G antibody in women with ectopic pregnancy (31/125; 25%) was significantly higher than in controls (12/125; 9.6%) (crude Odds Ratio [OR]: 3.1, 95% confidence interval [CI]: 1.51-6.38; p = 0.001). However, there was no significant association between C. trachomatis IgM; M. hominis IgG, IgM; U. urealyticum IgG, IGM; and HSV-2 IgG, and ectopic pregnancy. Conclusions Previous chlamydial infection plays an important role in the aetiology of ectopic pregnancy. There was no association between M. hominis, U. urealyticum and HSV-2 infections, and ectopic pregnancy. © 2013 The European Society of Contraception and Reproductive Health.


Ozaksit G.,Dr Zekai Tahir Burak Womens Health Education And Research Hospital | Tokmak A.,Dr Zekai Tahir Burak Womens Health Education And Research Hospital | Kalkan H.,Dr Zekai Tahir Burak Womens Health Education And Research Hospital | Yesilyurt H.,Dr Zekai Tahir Burak Womens Health Education And Research Hospital
Asian Pacific Journal of Cancer Prevention | Year: 2015

Background: Relationships between poor prognosis of ovarian malignancies and changes in complete blood count parameters have been proposed previously. In this work, we aimed to evaluate clinicopathologic features in adolescents with adnexal masses and sought to establish any predictive value of the platelet to lymphocyte ratio (PLR) in diagnosis. Materials and Methods: This retrospective study was conducted on 196 adolescent females with adnexal masses. Three groups were constituted with respect to clinical or histopathology results: group 1, non-neoplastic patients (n:65); group 2, neoplastic patients (n:68); and group 3 expectantly managed patients (n:63). The main parameters recorded from the hospital database and patient files were age, body mass index (BMI), chief symptoms, diameter of the mass (DOM), tumor marker levels, complete blood count values including absolute neutrophil, lymphocyte, and platelet counts, mean platelet volume, platelet distribution width, and platecrit, surgical features, and postoperative histopathology results. Results: The expectantly managed patients were younger than the other groups (p=0.007). The mean body mass index (BMI) was higher in the neoplastic group (p=0.016). Preoperative DOM, CA125, mean platelet volume and PLR were statistically significantly different between the groups (p<0.05). ROC curve analysis demonstrated that increased PLR (AUC, 0.609; p=0.011) and BMI (AUC, 0.611; p=0.011) may be discriminative factors in predicting ovarian neoplasms in adolescents preoperatively. When the cut-off point for the PLR level was set to 140, the sensitivity and specificity levels were found to be 65.7% and 57.6%, respectively. Conclusions: We suggest that beside a careful preoperative evaluation including clinical characteristics, ultrasonographic features and tumor markers, PLR may predict ovarian neoplasms in adolescents.


Ozkan N.T.,Dr Zekai Tahir Burak Womens Health Education And Research Hospital | Tokmak A.,Dr Zekai Tahir Burak Womens Health Education And Research Hospital | Guzel A.I.,Dr Zekai Tahir Burak Womens Health Education And Research Hospital | Ozkan S.,Kecioren Training and Research Hospital | Cicek M.N.,Dr Zekai Tahir Burak Womens Health Education And Research Hospital
Australian and New Zealand Journal of Obstetrics and Gynaecology | Year: 2015

Background: Endometrial polyps are common benign gynaecologic disorders. The etiopathogenesis of this condition remains unclear, however obesity is an important risk factor for the development of endometrial polyps. Aim: The aim of the study was to evaluate a possible association between endometrial polyps and clinical parameters of metabolic syndrome (MetS). Materials and Methods: Forty-five women with endometrial polyps (study group) and 45 without (control group) were included in this cross-sectional study. The main parameters evaluated between the groups were age, BMI (body mass index), waist circumference (WC), blood pressure, serum lipid profiles, fasting glucose levels and homeostatic model assessment of insulin resistance (HOMA-IR). Results: There was a significant difference between the groups in terms of BMI, WC, insulin levels and HOMA-IR (P < 0.05). The MetS was present in 32 (71.1%) of women in the study group and in 6 (13.3%) in the control group (P < 0.001). Logistic regression demonstrated that MetS was a significant risk factor for endometrial polyps. ROC curve analysis also showed that MetS was the most significant discriminative risk factor in the study group with an AUC of 0.789 (0.691-0.887; CI 95%). Conclusion: Our study suggests that there may be a relationship between endometrial polyps, MetS and insulin resistance. Further studies are required to explain the role of this relationship in the pathogenesis of the disease.


PubMed | Konya Education and Research Hospital and Dr Zekai Tahir Burak Womens Health Education And Research Hospital
Type: Journal Article | Journal: Andrologia | Year: 2016

Our aim was to compare peripheral blood and seminal fluid serum amyloid A (SAA) protein levels in men classified on the basis of sperm concentration and investigate whether SAA protein is an important marker of male infertility. A total of 74 first-attempt IVF male partners of infertile couples classified as azoospermic (n=25), oligozoospermic (n=25) and normozoospermic group (n=24) were recruited for this cross-sectional study. There was no difference with respect to age, BMI, infertility period and smoking ratio. No difference in haematologic parameters including white blood cell count, neutrophil ratio, lymphocyte ratio, neutrophil-to-lymphocyte ratio and blood SAA level was found between the groups. Seminal fluid SAA level was 17.852.21ngml(-1) in azoospermics, 16.133.58ngml(-1) in oligozoospermics and 15.67 4.77ngml(-1) in normozoospermics, showing no significant difference. Seminal SAA level was found to be not correlated with blood SAA levels. Therefore, we could not find any associations between these parameters at all. However, further studies with more participants are needed to address the exact action of SAA on spermatogenesis.


PubMed | Konya Education and Research Hospital and Dr Zekai Tahir Burak Womens Health Education And Research Hospital
Type: Journal Article | Journal: Pregnancy hypertension | Year: 2016

To investigate Apo A-1 and Apo B-100 levels and Apo B-100/Apo A-1 ratios in preeclamptic (PE) patients.Forty-eight PE and 48 without PE patients (healthy pregnancies) matched for gestational age were included. Maternal age, parity, gestational age at delivery, obstetrical complications including intrauterine growth restriction (IUGR) and gestational diabetes mellitus (GDM), serum Apo A-1 and Apo B-100 levels, and the Apo B-100/Apo A-1 ratio were compared.Preeclamptic patients had significantly lower Apo A-1 levels (167.07mg/dl14.61mg/dl vs. 244.37mg/dl20.84mg/dl, p<0.001), higher Apo B-100/Apo A-1 ratio (0.630.07 vs. 0.420.05, p<0.001), but similar Apo B-100 levels (104.84mg/dl7.05mg/dl vs. 102.39mg/dl8.08mg/dl, p=0.118). Mean Apo A-1 and Apo B-100 levels and the Apo B-100/Apo A-1 ratio were similar in patients with severe PE, HELLP syndrome, IUGR, and patients requiring antihypertensive therapy compared to PE patients who did not have these complications (p>0.05). Apo A-1 levels had the best accuracy followed by the Apo B-100/Apo A-1 ratio in patients with PE.Apo A-1 and the Apo B-100/Apo A-1 ratio may be useful markers in patients with PE. Further studies are required to elucidate this issue.

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