Dr Vm Government Medical College

Solāpur, India

Dr Vm Government Medical College

Solāpur, India
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Prasad H.B.,Dr Vm Government Medical College | Borse R.T.,RCSM Government Medical College | Avate A.N.,Bj Government Medical College | Palasdeokar N.,Bj Government Medical College
Journal of Association of Physicians of India | Year: 2017

Introduction: Plasmapheresis is an important modality for the treatment of GBS. Moreover the response to this treatment modality is not same in all cases. We therefore studied the various prognostic indicators of response to plasmapheresis in patients of Guillain Barre Syndrome. Materials and Methods: 40 patients were included in the study. Thorough clinical examination was done. Nerve conduction was done to find out the type of neuropathy. All were then given plasmapheresis. Prognostic indicators with reference to Age, sex, presenting severity, time between onset of illness and arrival to hospital, time taken to start plasmapheresis, number of plasmapheresis cycles, respiratory involvement, and type of neuropathy were studied. Results: There were 57.5% females and 47.5% males. Majority (82%) patients were in the age group of 20 to 60 years. All the patients had power grade 1 or 2 on admission but on discharge the power was grade 3 to 5 in 29 (80.55%) patients. The number of patients who received 5 cycles was 34(85%) and those who received 4 cycles of plasmapheresis was 6(15%). AIDP (acute inflammatory demyelinating polyneuropathy) was seen in 36 (90%) pts and AMAN (Acute Motor axonal Neuropathy) was seen in 4 (10%) patients. The severity at presentation and improvement was similar for all ages. Those who received plasmapheresis late showed power improvement of 2 to 3 grade in (50%) whereas those who received early showed improvement of 2 or 3 grade power in 82.14% patients indicating better improvement with early plasmapheresis. No difference was seen in grade of power improvement in 4 or 5 cycles of plasmapheresis. The number of patients on mechanical ventilation were 13 (40.62%) AIDP cases and 4 (100%) AMAN cases indicating more respiratory involvement in AMAN patients. All four patients of AMAN put on mechanical ventilation died of Ventilator associated pneumonia. Conclusion: Early treatment with plasmapheresis has better outcome in patients of GBS.four and five cycles of plasmapheresis are equally beneficial. © 2017, Journal of the Association of Physicians of India. All rights reserved.

Jain M.,Canadian Department of National Defence | Goel A.K.,Canadian Department of National Defence | Bhattacharya P.,Canadian Department of National Defence | Ghatole M.,Dr Vm Government Medical College | Kamboj D.V.,Canadian Department of National Defence
Acta Tropica | Year: 2011

Cholera is a fatal diarrheal disease characterized with enormous fluid loss through stools. A total of 41 Vibrio cholerae isolates collected from a recent cholera outbreak in Solapur, South Western India were found to belong to serogroup O1, biotype El Tor and serotype Ogawa. Molecular analysis revealed the prevalence of different toxigenic and pathogenic genes in the isolates. All the isolates harboured rstREl Tor allele indicating the presence of CTXΦEl Tor. However, cholera toxin (ctxB) gene sequencing and a ctxB allele specific PCR of the isolates confirmed the presence of ctxB of classical biotype. The antibiogram profile revealed the resistance for several antibiotics including nalidixic acid, polymyxin B, streptomycin, sulfamethoxazole, trimethoprim, rifampicin and vibriostatic agent 2,4-diamino-6,7-diisopropylpteridine (O/129). All the isolates were PCR positive for class 1 integron and SXT elements also. Fingerprinting analysis revealed the clonal relationship among the outbreak isolates. The results suggested the involvement of multidrug resistant V. cholerae El Tor biotype isolates having ctxB gene of classical biotype in the cholera outbreak. © 2010 Elsevier B.V.

Dhotre P.S.,Tal Medical | Suryakar A.N.,Maharashtra University of Health Sciences | Bhogade R.B.,Dr Vm Government Medical College
European Journal of General Medicine | Year: 2012

Periodontitis is one of the most common oral infections induced by bacteria and bacterial products of dental plaque. Cigarette smoking is considered to be a risk factor for periodontitis. However, the exact mechanism by which smoking exerts its deleterious effects on periodontium remains unclear. Therefore the present study was planned to evaluate the relationship between cigarette smoking and periodontal damage in terms of the levels of free radicals and antioxidants. A total of 75 subjects were included in the study. Out of these, 25 were healthy controls, 25 were nonsmoker periodontitis patients and 25 were smoker periodontitis patients. All subjects were screened for serum lipid peroxide, nitric oxide and antioxidants such as superoxide dismutase, glutathione peroxidase along with total antioxidant capacity. A significant increase in serum lipid peroxide and nitric oxide with a corresponding decrease in serum superoxide dismutase, glutathione peroxidase and total antioxidant capacity was observed in both groups of periodontitis patients. Further, it was noticed that the oxidant levels were significantly higher and antioxidants were significantly lower in smoker patients than non-smoker patients. Thus, smoking plays a pivotal role in enhancing oxidative burden in periodontitis.

Bhogade R.B.,Dr Vm Government Medical College | Suryakar A.N.,Maharashtra University of Health Sciences | Joshi N.G.,Dr Vm Government Medical College
European Journal of General Medicine | Year: 2013

For human beings trace elements are essential nutrients with a gamut of functions. Available data regarding trace element status in hemodialysis patients are contradictory. The present study was aimed to investigate possible existence of trace element disturbances in uremic patients undergoing dialysis treatment. Blood samples of forty hemodialysis patients and twenty healthy controls were analyzed for quantitation of copper and zinc. The study revealed that serum copper and zinc concentrations in hemodialysis patients are distinctly decreased compared to that of healthy controls. Abnormalities of trace elements are primarily the result of uremia, and they may be further exacerbated by the dialysis procedure.

Kulkarni P.R.,Dr Vm Government Medical College | Makandar U.K.,Ss Institute Of Medical Science And Research Center
Indian Journal of Forensic Medicine and Toxicology | Year: 2012

25 Male Cadveric hearts preserved in formalin in the dept of Anatomy dissection theatre of Dr V.M. Govt Medical College Solapur were studied metrically and morphologically. 1) The mean value of the mitral valve Circumference was 8.97 cm with (SD ± 0.7). 2) The mean value of length of anterior leaf let was 1.8 cm and that of posterior leaf let was 1.4 cm. 3) Thickness of both ant and posterior leaflets was having same mean value of O.2 cm(SD ± 0.44cm). 4) Length of papillary muscle i.e. mean length of anterio- lateral Papillary muscle was 1.8 cm (SD±0.3) and post. Med. Papillary muscle was 1.6 cm(SD±0.3). There all observations were more or less in agreement with previous workers 1,2 but Incidence of heads of papillary muscle differed with previous workers 1. Morphologically the leaf lets were smooth, Crescent shaped and shape of annulus was Saddle shaped or 'D' Shaped and non-planar. Both papillary muscles with intact chorda tendane were observed which indicates normalcy of "Mitral Valve".

Makandar U.K.,Ss Institute Of Medical Science And Research Center | Kulkarni P.R.,Dr Vm Government Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2014

In the present study 540 dried, non-pathological crania were studied cranial index was measured by spreading caliper and cranial capacity was studied by filling mustard seeds through foramen magnum. There was significant correlation between these two values. Mean value of cranial capacity was 1171.24(SD=113) and cranial index was 75.13(SD=3.47). Regression equation of cranial index and cranial capacity were linearly accepted with significant P<0.008 value cranial capacity (x) = 1452.63 37y and cranial index (y) = 79.27 - 0.004x. By known cranial index the cranial capacity can be anticipated and vice versa. This study will help the clinician by providing base line data, Medico-legal expert, Neurosurgeon, Radiologist in their respective fields. Anthropologist to identify race and sex. These present values differ with previous foreign workers hence this study indicates the regional significance. © 2014, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.

Dhadke S.V.,Dr Vm Government Medical College | Dhadke V.N.,Dr Vm Government Medical College | Bangar S.S.,Dr Vm Government Medical College | Korade M.B.,Dr Vm Government Medical College
Journal of Association of Physicians of India | Year: 2013

Objectives: To study clinical presentation, hospital care and outcome of patients of Guillain Barre Syndrome (GBS) and number of patients of respiratory failure and need for v entilators. To study efficacy of IVIg in patients of GBS. Material and Methods: 40 patients of GBS studied in detail including history, clinical examination and investigations {Nerve conduction velocity and C.S.F. examination}. All patients were watched for respiratory insufficiency and those who developed respiratory paralysis were given assisted mechanical ventilation. Patients were treated with IVIG and outcome was observed. Outcome of 2 groups of patients one treated with IVIg and other not treated with IVIg (supportiv e line of treatment) w ere compared. Results: Commonest age group affected was 13-40 yrs. The male:female ratio was 1.5:1. Antecedent infection in form of fever, cough [11 patients], loose motions [10 patients] were present in 21 out of 40 patients. Quadriparesis was present in 39 patients and paraparesis in 1 patient. Cranial nerve involvement was seen in 25 out of 40 patients. Facial nerve was involved in 12[30%] patients and Glossopharyengeal, vagus nerves were involved in 12[30%] patients. Areflexia was found in all 40 patients. In CSF examination, albuminocytologic dissociation was present in 17 out of 26 patients. NCV findings show conduction velocity slowing, delayed f latencies in 90% patients. Out of 40 patients,13[30%] required mechanical ventilation. Out of 40 patients, 14 were treated with IVIg, 4 patients treated with plasmapheresis and 22 patients received only supportive treatment. Out of 40 patients 30 [75%] patients recovered completely, 8 [20%] patients died and 2 [5%] patients dev eloped severe neurologic deficit. Conclusion: GBS is more common in 13-40 yrs age group with male:female ratio of 1.5:1. Antecedent infection is seen in 55% patients. Commonest presentation was paresthesia in legs and ascending paralysis. One third [32.5%] patients developed respiratory paralysis and needed ventilatory support. Patients who received IVIg early in the course of disease had faster recovery as compared to patients who received only supportive line of treatment. © JAPI.

Pujari V.M.,R.I.M.S. | Suryakar A.N.,Dr Vm Government Medical College | Ireddy S.,R.I.M.S.
Biomedical Research | Year: 2010

The imbalance in to oxidants and antioxidants leads to the condition called oxidative stress. The oxidative stress is considered as one of the etiopathological factors for development and /or exacerbation of psoriasis. Therefore we undertook this study to determine serum levels of oxidants (Malondialdehyde MDA, Nitric oxide NO) and antioxidants (Total Antioxidant Status TAS, Superoxide Dismutase SOD) and it's correlation with severity of psoriasis. In present research work we have studied 90 clinically diagnosed psoriasis patients and 90 age and sex matched healthy control subjects. Our results showed increased concentration of oxidants; MDA, NO, and decreased concentration of TAS as well as activity of SOD in the serum of psoriasis patients. Observations of our study clearly indicate positive correlation of increasing serum oxidants and negative correlation of decreasing serum antioxidants with PASI scour i.e. severity of psoriasis.

Bhutkar M.V.,Mr Medical College | Bhutkar P.M.,Mr Medical College | Taware G.B.,Dr Vm Government Medical College | Surdi A.D.,Dr Vm Government Medical College
Asian Journal of Sports Medicine | Year: 2011

Purpose: The purpose of the present study was to evaluate effects of regular practice of sun salutation on muscle strength, general body endurance and body composition. Methods: Subjects (49 male and 30 female) performed 24 cycles of sun salutation, 6 days a week for 24 weeks. Upper body muscle strength was determined by 1 repetition maximum (1RM) for bench press and shoulder press technique. Back and leg dynamometry was used to assess strength of back and leg muscles. General body endurance was evaluated by push-up and sit-up tests. Body composition was assessed by noting % body fat by using bioelectric impedance analysis. Perceived intensity of exercise by subjects was noted by Borg scale. Results: Muscle strength by bench press showed significant increase in male (29.49±9.70 to 36.12±9.09 Kg, P<0.001) and female (10.5±4.42 to 13.16±4.44 Kg, P<0.001) subjects. Strength by shoulder press also increased (males; 22.96±9.57 Kg to 26.53±11.05 Kg, P<0.001, females; 6.83±2.78 to 8.83±3.87, P<0.001). Endurance by push-ups & sit-ups showed similar findings in male (19.0±9.58 to 21.98±8.98, P<0.001 and 24.92±10.41 to 29.84±12.64, P<0.001 respectively) and female (14.66±6.80 to 18.56±6.97 and 13.16±7.75 to 19.23±8.25, P<0.001 respectively) subjects. A significant decrease in body fat percent was observed only in female (27.68±5.46 to 25.76±4.72, P<0.001) but not in male subjects. BMI significantly decreased in both the groups (z=4.37, P<001 and t=5.41, P<0.001 respectively). Conclusion: From our observations we conclude that sun salutation can be an ideal exercise to keep oneself in optimum level of fitness. © 2011 by Sports Medicine Research Center, Tehran University of Medical Sciences, All rights reserved.

Bhagat S.S.,Al Ameen Medical College | Ghone R.A.,A.C.P.M.C. Dhule | Suryakar A.N.,Dr Vm Government Medical College | Hundekar P.S.,A.C.P.M.C. Dhule
Indian Journal of Physiology and Pharmacology | Year: 2011

Reactive Oxygen Species (ROS) can induce carcinogenesis via DMA injury. Both enzymatic and non-enzymatic antioxidants participate in cell protection against harmful influence of oxidative stress. The aim of the present study was to assess the level of end product of lipid peroxidation such as malondialdehyde (MDA) as an oxidant in colorectal cancer. Moreover, we analyzed the activity of main non-enzymatic antioxidants, vitamin E and vitamin C in colorectal cancer patients. In the present study, total 48 samples were analyzed which includes 24 age matched healthy controls irrespective of sex (Group I) and 24 cases of colorectal cancer (Group II). The serum level of lipid peroxide, vitamin E and vitamin C were estimated in both healthy control Group I (n=24) and colorectal cancer Group II (n=24). A significant increase in the level of serum lipid peroxide (P<0.001), with concomitant decrease in the levels of serum vitamin E and vitamin C, (P<0.001) in Group II patients were noticed as compared to the healthy control Group I. Our findings suggest that increased oxidative stress and reduced antioxidants defense mechanism may play an important role in progression and pathogenesis of colorectal cancer.

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