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Sulegaon R.,Bidar Institute of Medical science | Shete S.,Dr Vm Government Medical College | Kulkarni D.,Bidar Institute of Medical science
Journal of Clinical and Diagnostic Research | Year: 2015

Introduction: Large intestine is affected by various types of lesions, both non-neoplastic and neoplastic. Due to vague symptoms, the clinical diagnosis is usually delayed. A battery of laboratory tests including biopsy is essential to arrive at a specific diagnosis for appropriate management. Materials and Methods: This five years study was done during the period of 2005 to 2010 in a tertiary care centre which included 124 biopsies and resected specimens of large intestine and 64 from Anal canal. All tissues were fixed in formalin, stained with H&E and special stains like Periodic Acid Schiff (PAS), Reticulin, Zeihl Neelsen (ZN) along with Immunohistochemistry (IHC) were done as and when required. Results: Out of the 124 cases of large intestine 38 were non-neoplastic, 77 were neoplastic and 9 were inadequate biopsies. Sixty four cases from Anal canal included 55 non-neoplastic and 9 neoplastic lesions. The non-neoplastic conditions included congenital anomalies, infective and ischaemic lesions while neoplastic included benign and malignant lesions. Most of the cases presented with symptoms like abdominal pain, vomiting and constipation. Conclusion: We observed that neoplastic lesions were more common in large intestine while non-neoplastic lesions were frequently seen in Anal canal. Present study emphasizes the need for early histopathological diagnosis for appropriate treatment. © 2015 Journal of Clinical and Diagnostic Research. All Rights Reserved. Source

Kulkarni P.R.,Dr Vm Government Medical College | Makandar U.K.,Ss Institute Of Medical Science And Research Center
Indian Journal of Forensic Medicine and Toxicology | Year: 2012

25 Male Cadveric hearts preserved in formalin in the dept of Anatomy dissection theatre of Dr V.M. Govt Medical College Solapur were studied metrically and morphologically. 1) The mean value of the mitral valve Circumference was 8.97 cm with (SD ± 0.7). 2) The mean value of length of anterior leaf let was 1.8 cm and that of posterior leaf let was 1.4 cm. 3) Thickness of both ant and posterior leaflets was having same mean value of O.2 cm(SD ± 0.44cm). 4) Length of papillary muscle i.e. mean length of anterio- lateral Papillary muscle was 1.8 cm (SD±0.3) and post. Med. Papillary muscle was 1.6 cm(SD±0.3). There all observations were more or less in agreement with previous workers 1,2 but Incidence of heads of papillary muscle differed with previous workers 1. Morphologically the leaf lets were smooth, Crescent shaped and shape of annulus was Saddle shaped or 'D' Shaped and non-planar. Both papillary muscles with intact chorda tendane were observed which indicates normalcy of "Mitral Valve". Source

Makandar U.K.,Ss Institute Of Medical Science And Research Center | Kulkarni P.R.,Dr Vm Government Medical College
Indian Journal of Forensic Medicine and Toxicology | Year: 2014

In the present study 540 dried, non-pathological crania were studied cranial index was measured by spreading caliper and cranial capacity was studied by filling mustard seeds through foramen magnum. There was significant correlation between these two values. Mean value of cranial capacity was 1171.24(SD=113) and cranial index was 75.13(SD=3.47). Regression equation of cranial index and cranial capacity were linearly accepted with significant P<0.008 value cranial capacity (x) = 1452.63 37y and cranial index (y) = 79.27 - 0.004x. By known cranial index the cranial capacity can be anticipated and vice versa. This study will help the clinician by providing base line data, Medico-legal expert, Neurosurgeon, Radiologist in their respective fields. Anthropologist to identify race and sex. These present values differ with previous foreign workers hence this study indicates the regional significance. © 2014, Indian Journal of Forensic Medicine and Toxicology. All rights reserved. Source

Bhagat S.S.,Al Ameen Medical College | Ghone R.A.,A.C.P.M.C. Dhule | Suryakar A.N.,Dr Vm Government Medical College | Hundekar P.S.,A.C.P.M.C. Dhule
Indian Journal of Physiology and Pharmacology | Year: 2011

Reactive Oxygen Species (ROS) can induce carcinogenesis via DMA injury. Both enzymatic and non-enzymatic antioxidants participate in cell protection against harmful influence of oxidative stress. The aim of the present study was to assess the level of end product of lipid peroxidation such as malondialdehyde (MDA) as an oxidant in colorectal cancer. Moreover, we analyzed the activity of main non-enzymatic antioxidants, vitamin E and vitamin C in colorectal cancer patients. In the present study, total 48 samples were analyzed which includes 24 age matched healthy controls irrespective of sex (Group I) and 24 cases of colorectal cancer (Group II). The serum level of lipid peroxide, vitamin E and vitamin C were estimated in both healthy control Group I (n=24) and colorectal cancer Group II (n=24). A significant increase in the level of serum lipid peroxide (P<0.001), with concomitant decrease in the levels of serum vitamin E and vitamin C, (P<0.001) in Group II patients were noticed as compared to the healthy control Group I. Our findings suggest that increased oxidative stress and reduced antioxidants defense mechanism may play an important role in progression and pathogenesis of colorectal cancer. Source

Pujari V.M.,RIMS | Suryakar A.N.,Dr Vm Government Medical College | Ireddy S.,RIMS
Biomedical Research | Year: 2010

The imbalance in to oxidants and antioxidants leads to the condition called oxidative stress. The oxidative stress is considered as one of the etiopathological factors for development and /or exacerbation of psoriasis. Therefore we undertook this study to determine serum levels of oxidants (Malondialdehyde MDA, Nitric oxide NO) and antioxidants (Total Antioxidant Status TAS, Superoxide Dismutase SOD) and it's correlation with severity of psoriasis. In present research work we have studied 90 clinically diagnosed psoriasis patients and 90 age and sex matched healthy control subjects. Our results showed increased concentration of oxidants; MDA, NO, and decreased concentration of TAS as well as activity of SOD in the serum of psoriasis patients. Observations of our study clearly indicate positive correlation of increasing serum oxidants and negative correlation of decreasing serum antioxidants with PASI scour i.e. severity of psoriasis. Source

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