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Thiruvananthapuram, India

Remesh A.,Dr Smcsi Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Pharmacovigilance mainly involve monitoring and reporting of Adverse Drug Reactions associated with the use of medicinal products. Under-reporting of Adverse Drug Reactions is a serious issue hampering the dynamics of Pharmacovigilance programme. Pharmacovigilance is a shared responsibility of all the stake holders. This study was mainly aimed to assess the Knowledge, Attitude and Perceptions of Health care Professionals towards Pharmacovigilance and estimate factors contributing to under reporting of Adverse Drug Reactions. This was a cross sectional observational questionnaire based study done in a tertiary care hospital in South India. Healthcare professionals who responded (71.4%) includes prescribers, nurses and pharmacists. There was an increase in the awareness and attitude of Health care professionals towards Pharmacovigilance. But inadequate training in methodology of reporting ADR was the main problem. There is a need to provide adequate basic training to all health care professionals by educational interventions through nearest Pharmacovigilance units. It should be of good quality as well as cost affordable.

Sajitha G.R.,Sree Mookambika Institute of Medical science | Jose R.,Dr Smcsi Medical College | Andrews A.,University Center | Ajantha K.G.,University Center | Augustine P.,The Surgical Center
Indian Journal of Clinical Biochemistry | Year: 2010

Daily feeding of drinking water containing lead acetate (160 mg/l) or 10% alcohol by volume or a combination of both to rats for a month produced certain deleterious effects through oxidative stress. Both heavy metal lead and alcohol are capable of doing such damages. The deleterious alterations observed were in the parameters of blood, serum and tissues, viz; Hb, Pb, proteins, lipids, lipid per oxidation, Vitamins C and E levels and enzyme activities of AST, ALT, and catalase. Simultaneous feeding of either of the two antioxidants garlic oil (GO) and vitamin E at equal doses of 100 mg/kg/day, to the rats counteracted the deleterious effects of the above two chemicals significantly. The maximum damage was brought about by feeding of drinking water containing both lead acetate and alcohol. The protective effects of GO and Vitamin E were not significantly different. The mechanism of actions of the Vitamin E and GO is probably due to their efficiency as detoxifying agents and antioxidants, to scavenging free radicals as well as an independent action of GO on the removal of lead salt as lead sulfide. © 2010 Association of Clinical Biochemists of India.

Prasad S.C.,Dr Smcsi Medical College | Korah S.,Christian Medical College
Middle East African Journal of Ophthalmology | Year: 2015

We report a rare case of ophthalmia nodosa, presenting as a painless swelling in the lower palpebral conjunctiva for 2 years with no signs of inflammation. Excision biopsy confirmed the diagnosis. © 2015 Middle East African Journal of Ophthalmology | Published by Wolters Kluwer - Medknow.

Thomas P.,Dr Smcsi Medical College | Bhatia T.,U.S. National Institutes of Health | Gauba D.,BSES Yamuna Power Ltd. | Wood J.,University of Pittsburgh | And 8 more authors.
Journal of Psychiatric Research | Year: 2013

Herpes simplex virus, type 1 (HSV-1) causes cold sores, keratitis and rarely, fatal encephalitis. The infection is lifelong, with sensory ganglia serving as reservoirs of latent infection. Recently, exposure to HSV-1 has also been repeatedly associated with reduced cognitive function among healthy individuals without prior encephalitis. Though HSV-1 does not elevate risk for schizophrenia (SZ) per se, exposure is likewise associated with impaired cognitive functions among SZ patients. The range of cognitive changes observed in HSV-1 exposed persons has not been investigated systematically, nor is it known whether interaction between HSV-1 exposure and SZ related factors contributes to the impairment among SZ patients. Persons with or without schizophrenia/schizophreniform disorder (N=298 total, DSM IV criteria) were assessed for HSV-1 exposure using serum HSV-1 antibody titers. The Penn Computerized Neurocognitive battery was used to assess eight cognitive domains with respect to accuracy and speed. There were no significant case-control differences in HSV-1 exposure. The SZ/schizophreniform disorder cases were significantly impaired in all cognitive domains compared with the controls. HSV-1 exposure was also associated with reduced cognitive function in the entire sample, but the magnitude of the effects and their patterns differed from the SZ related changes. Further, statistically significant interactions between HSV-1 exposure and SZ case status were not detected. HSV-1 exposure does not elevate risk for SZ, but it is associated with reduced function in specific cognitive domains regardless of SZ diagnostic status. An 'epidiagnostic' model for the association is proposed to explain the results. © 2013 Elsevier Ltd.

Remesh A.,Dr Smcsi Medical College
Journal of Clinical and Diagnostic Research | Year: 2013

Introduction: There are various strategies for overcoming the major pitfalls of cancer chemotherapy, such as toxicity and drug resistance. The scientific computing of drug scheduling by optimisation before drug administration is one among them. In a majority of these strategies, the pharmacodynamic variations are given more importance than the pharmacokinetic variations. This study was meant to analyse the importance of the pharmacokinetic parameters (φ) of the individual patients in cancer chemotherapy scheduling, along with the pharmacodynamic factors. Methods: A mathematical model is developed and it is implemented in the open source OCTAVE GNU LINUX. Optimisation is done by using an optimization tool in OCTAVE. The present study was aimed at evaluating the daily drug dosaging and cyclic chemotherapy which are commonly practised in the chemotherapy scheduling. Four cases were analyzed with and without considering the pharmacokinetic parameters. The optimal therapy was meant to reduce the number of cancer cells to a minimum at the end of the therapy and to minimise the emergence of resistant cancer cells. Since the dose was within tolerable limits, the toxic effects could also be minimised. Results: Even with the consideration of a 1 per cent effect (φ), the maximum possible dose and the performance index were increased in the daily scheduling. But in the cyclic therapy, even though the maximum tolerated dose or the performance index was not altered, the cumulative toxicity was greatly reduced. Conclusion: Daily scheduling and cyclic chemotherapy can be applied alternatively more effectively, by considering the interindividual variations in the pharmacokinetic effect (φ).

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