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Raut J.,University | Rathod V.,Dr Shankarrao Chavan Government Medical College | Karuppayil S.M.,University
Japanese Journal of Medical Mycology | Year: 2010

Cell surface hydrophobicity(CSH)of 50 clinical isolates of Candida albicans was studied, and values varied broadly in the range 2% to 41%. Purpose of the present work was to investigate correlation of CSH with the C. albicans adherence to solid surfaces, if any. To elucidate this, adhesion to the polystyrene model surface was studied for all the clinical isolates. Adherence varied in the range of 79 to 478 cells per microscopic field. Results indicated no correlation between CSH of the clinical isolates and their adhesion to polystyrene. Source

Tamboli S.B.,Dr Shankarrao Chavan Government Medical College
Bangladesh Journal of Medical Science | Year: 2013

Background: Calcium channel blockers are amongst the commonly used drugs in the treatment of cardiovascular disorders. They produce their action by blocking voltage regulated calcium channels. Methodolgy: Present study evaluated the effects of three structurally dissimilar calcium channel blockers Nitrendipine (a dihydropyridine) in a single dose of 10 mg and 20 mg, Diltiazem (a benzothiazepine) in a single dose of 30 mg and 60 mg and Verapamil (a phenylalkylamine) in a single dose of 40 mg and 80 mg on psychomotor performance in human volunteers. For evaluation of psychomotor performance, the tests used were arithmetic ability, verbal learning, letter cancellation, digit symbol substitution and card sorting test. Results: Nitrendipine both in low dose (10mg) and high dose (20mg) as well as Diltiazem in high dose (60mg) and Verapamil in high dose (80mg) were found to impair the psychomotor performance in human volunteers to a statistically significant extent in all the tests employed except letter cancellation test. Whereas Diltiazem in low dose (30mg) and Verapamil in low dose (40mg) showed statistically significant impairment of psy-chomotor performance using arithmetic ability, verbal learning, and digit symbol substitution test. Conclusion: Thus calcium channel blockers namely Nitrendipine, Diltiazem and Verapamil significantly impaired the psychomotor performance of human volunteers in our study. Source

Rathod V.S.,Dr Shankarrao Chavan Government Medical College | Raut J.S.,SAP | Mohan Karuppayil S.,SAP
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

Infections due to fungal pathogens are on the rise. Systematic studies on antifungal drug susceptibility which may be useful in deciding clinical strategies are not routinely done in India and other developing countries. Aim of this study was testing sensitivity of clinical isolates of Candida albicans to frequently prescribed antifungal drugs, fluconazole, ketoconazole, clotrimazole, amphotericin B and terbinafine. Thirty one strains of C. albicans were isolated from patients visiting a tertiary care urban hospital in Maharashtra, India. Presumptive identification of C. albicans was done on HiCHROM agar-Candida. Confirmation was done by Germ tube formation assay, carbohydrate assimilation test and Corn meal agar test. Isolates were tested in vitro for susceptibility to five antifungal agents, by using standard broth micro dilution method. All the experiments were performed in triplicates. Results of this study revealed dose dependent susceptibility to fluconazole in 16% of isolates. Resistance to ketoconazole and clotrimazole was observed in 23 % and 10 % isolates, respectively. All the isolates were sensitive to amphotericin B (a polyene) and terbinafine (an allylamine). One isolate was found resistant to ketoconazole and clotrimazole, at the same time S-DD to fluconazole. Occurrence of resistance to ketoconazole and clotrimazole, as well as dose dependent susceptibility to fluconazole, alarms emergence of multiple drug resistance among Indian clinical isolates of C. albicans. Although fluconazole could still be used effectively, S-DD isolates may become resistant upon repeated exposure to the drug. Hence, caution need to be taken while prescribing these azoles. Source

Bagwan N.A.,Institute of Medical Science and Research | Mor S.,Dr Shankarrao Chavan Government Medical College | Gujar V.,Dr Shankarrao Chavan Government Medical College
Journal of Krishna Institute of Medical Sciences University | Year: 2014

Background: While many patients are admitted to hospital for treatment of infections, some acquire infection during their stay in the hospital. These infections are called as nosocomial infections. Surgical site infection or post operative wound infection is one of them. It is defined as infection of previously sterile tissue incised to gain exposure for operating deeper spaces operatively exposed or organs manipulated by a surgeon. It is one of the feared complications of surgery as it increases morbidity as well as cost of medical care. Aims and Objectives: Study was conducted to find out incidence of surgical site infection rate in surgical ward, evaluate various factors contributing to infection and to identify causative pathogens and their antibiogram patterns. Material and Methods: All clean and clean contaminated operative cases admitted in surgery ward in study period of 18 months were included. Preoperative, operative and postoperative management protocols of the cases were recorded in detail. Results: A total of 1082 operated cases were studied among which 59 infected cases were found. Surgical Site Infection (SSI) rate was 5.45%. E. coli and Staphylococcus aureus were the commonest pathogen isolated from the infected wound. 50 % were Methicillin Resistant Staphylococcus Aureus (MRSA) among them and 50% of Enterobacteriaceae group were resistant to 3rd generation Cephalosporins. Conclusion: Surgical site infection rate of a hospital can be reduced easily by following proper pre-operative protocol for the patients. Those patients with surgical site infection can be treated effectively by following the antibiotic policy as provided by the Department of Microbiology. © Journal of Krishna Institute of Medical Sciences University. Source

Zanjad N.P.,Dr Shankarrao Chavan Government Medical College
Journal of Indian Academy of Forensic Medicine | Year: 2014

Gagging is a form of asphyxia which results from forcing a gag such as rolled up cloth, paper etc. deep in to the mouth or oropharynx. As such asphyxia by gagging is rare in occurrence and usually seen in infants and children as homicidal act or in adults suffering from psychiatric disorder as suicidal form of gagging. As young ones and elder people are easily overpowered due to least resistance offered by them, the homicidal gagging is more common in this age group. We report a case of gagging in unknown newborn male which was found in polythene bag in open garbage area. During autopsy a rolled up cloth was observed in buccal cavity and on internal examination the gag was seen deep inside the mouth surrounded by mucus. In such cases, meticulous examination of nasopharynx, oropharynx and gag material is important. Source

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