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Kocabas B.A.,Ankara University | Karbuz A.,Ankara University | Timur O.M.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Ciftci E.,Ankara University | Ince E.,Ankara University
Cocuk Enfeksiyon Dergisi | Year: 2014

Shigella is one of the causative agents of gastroenteritis and antimicrobial treatment in addition to hydration therapy can significantly reduce the mortality related to infection. Although seroprevalence of the Shigella infections varies between countries, Shigella sonnei is the first and Shigella flexneri the second most common isolated species in our country. A higher antibiotic resistance rate is reported in S. flexneri infections compared to other Shigella species. Herein, we report a case who presented with acute gastroenteritis due to ceftriaxone-resistant S. flexneri. This infection was complicated with severe dehydration, protein-losing enteropathy and was successfully treated with ciprofloxacin and meropenem. © 2014 by Pediatric Infectious Diseases. Source


Aydin B.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Ipek M.S.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Ozaltin F.,Hacettepe University | Zenciroglu A.,Dr Sami Ulus Maternity And Children Training And Research Hospital | And 8 more authors.
Genetic Counseling | Year: 2013

Pierson syndrome is a rare autosomal recessive disorder which is mainly characterized by congenital nephrotic syndrome (CNS), diffuse mesangial sclerosis (DMS) and distinct ocular abnormalities, including microcoria. Most affected children exhibit early onset of chronic renal failure, neurodevelopmental deficits, and blindness. It is caused by a homozygous or compound heterozygous mutation in the gene encoding laminin beta-2 (LAMB2) on chromosome 3p21. In this article, we report on a patient with CNS, bilateral megalocornea and microcoria. The patient had developed renal failure at very early postnatal period and died of septic shock. A novel homozygous donor splice mutation (IVS4 + 2T > C) in LAMB2 gene was identified in the patient. Source


Esin S.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Baser E.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Okuyan E.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Kucukozkan T.,Dr Sami Ulus Maternity And Children Training And Research Hospital
Journal of Minimally Invasive Gynecology | Year: 2013

Study Objective: To compare the effectiveness of sublingual misoprostol with lidocaine pump spray for office hysteroscopy. Design: Premenopausal women who had an indication for office hysteroscopy were included in this randomized, double-blind, placebo-controlled study. Eighty-two patients were evaluable for the final analysis. Setting: A tertiary referral center. Patients: Premenopausal women who had an indication for office hysteroscopy were included. Eighty-two patients were evaluable for the final analysis. Interventions: Patients were randomized to receive either sublingual misoprostol and placebo of lidocaine or lidocaine pump spray applied to the cervix and placebo of misoprostol. Measurements and Main Results: When compared with the lidocaine group, patients in the misoprostol group reported less pain by the immediate visual analog scale scores (2.2 ± 0.98 vs 2.6 ± 0.99, p = .030), whereas visual analog scale scores at 10 minutes were similar between groups (2.1 ± 0.98 vs 2.36 ± 1.06, p = .156). Conclusion: Sublingual misoprostol is more effective than lidocaine spray in pain reduction during office hysteroscopy. Misoprostol may cause vaginal spotting, which may impair the vision during hysteroscopy especially just after the menstrual period. Preventive measures should be taken to make the procedure pain free because the physician may underestimate painperception during the procedure. © 2013 AAGL. Source


Fettah N.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Dilli D.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Beken S.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Zenciroglu A.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Okumus N.,Dr Sami Ulus Maternity And Children Training And Research Hospital
Pediatric Emergency Care | Year: 2014

BACKGROUND: Near drowning is the term for survival after suffocation caused by submersion in water or another fluid. Pulmonary insufficiency may develop insidiously or suddenly because of near drowning. AIM: We want to present a newborn case of acute respiratory distress syndrome caused by near drowning. CASE: A 26-day-old boy was brought to the emergency department because of severe respiratory distress. Two hours before admission, the baby suddenly slipped out his mother's hands and fell in the bathtub full of water while bathing. After initial resuscitation, he was transferred to the neonatal intensive care unit for mechanical ventilation. PaO2/FIO2 ratio was 97, with SaO2 of 84%. Bilateral heterogeneous densities were seen on his chest x-ray film. The baby was considered to have acute respiratory distress syndrome. Antibiotics were given to prevent infection. Because conventional therapy failed to improve oxygenation, a single dose of surfactant was tested via an intubation cannula. Four hours later, poractant alfa (Curosurf) administered repeatedly at the same dosage because of hypoxemia (PaO2/FIO2 ratio, 124; SaO2, 88%). Oxygen saturation was increased to more than 90% in 24 hours, which was maintained for 3 days when we were able to wean him from mechanical ventilation. After 7 days, the x-ray film showed considerable clearing of shadows. He was discharged home on the 15th day after full recovery. CONCLUSIONS: This case report describes a rapid and persistent improvement after 2 doses of surfactant in acute respiratory distress syndrome with severe oxygenation failure caused by near drowning in a newborn. Copyright © 2014 Lippincott Williams & Wilkins. Source


Esin S.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Baser E.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Cakir C.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Ustun Tuncal G.N.,Dr Sami Ulus Maternity And Children Training And Research Hospital | Kucukozkan T.,Dr Sami Ulus Maternity And Children Training And Research Hospital
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2013

Objective: The objective of the study was to compare bitter chocolate and orange juice with the control group for non-reactive non-stress test (NST) patterns and for maternal perception of fetal movements. Study design: Pregnant women who were followed-up on an outpatient basis and admitted for a NST and had a non-reactive result were randomized prospectively into bitter chocolate, orange juice and control groups. 180 patients were evaluable for the final analysis. Results: Although there was a trend for orange juice group for having higher percentages of reactive NST patterns on control, there was no statistically significant difference between three groups (p=0.159). Besides this, maternal perception of increased fetal movements was similar between groups (p=0.755). The control group had lower post-test capillary blood glucose concentrations when compared with chocolate and orange juice groups (p=0.01) and after post-hoc tests, this difference was found to be between orange juice and control groups. Conclusions: Although orange juice resulted in higher blood glucose levels, this was not synonymous with better NST results on control; in such a way that bitter chocolate, orange juice and no intervention had similar effects on non-reactive NST patterns and also on maternal perception of fetal movements. © 2013 Informa UK Ltd All rights reserved. Source

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