Dr. Reddys Labs Ltd
Dr. Reddys Labs Ltd
Kapoor D.N.,Panjab University |
Kapoor D.N.,Oniosome Healthcare Pvt. Ltd. |
Katare O.P.,Panjab University |
Dhawan S.,Panjab University |
Dhawan S.,Dr. Reddys Labs Ltd
International Journal of Pharmaceutics | Year: 2012
An injectable, phase sensitive, in situ forming, implantable delivery system was developed for enfuvirtide, a therapeutic peptide used in the treatment of HIV infection. The development studies were carried out using poly (d,l-lactide-co-glycolide), a smart, biodegradable polymer. Different formulations were designed, prepared and evaluated by employing response surface, optimal design of experiment technique. The optimized formulation was identified and validated for its performance by using numerical optimization technique. The in vitro evaluation parameters included rheology, compatibility studies, drug release as well as conformational and physicochemical stability studies. In vivo pharmacokinetic parameters and biocompatibility studies were determined in rat models and were statistically analyzed. It was found that the optimized formulation extended the enfuvirtide release and maintained the drug plasma concentration within therapeutically effective range up to 48 h. The optimized formulation maintained physicochemical and conformational stability for at least 6 months and was biocompatible with the animal tissue. © 2012 Elsevier B.V. All rights reserved.
Kapoor D.N.,Lovely Professional University |
Bhatia A.,Lovely Professional University |
Kaur R.,Lovely Professional University |
Sharma R.,Lovely Professional University |
And 3 more authors.
Therapeutic Delivery | Year: 2015
Biodegradable polymers have played an important role in the delivery of drugs in a controlled and targeted manner. Polylactic-co-glycolic acid (PLGA) is one of the extensively researched synthetic biodegradable polymers due to its favorable properties. It is also known as a 'Smart Polymer' due to its stimuli sensitive behavior. A wide range of PLGA-based drug delivery systems have been reported for the treatment or diagnosis of various diseases and disorders. The present review provides an overview of the chemistry, physicochemical properties, biodegradation behavior, evaluation parameters and applications of PLGA in drug delivery. Different drug-polymer combinations developed into drug delivery or carrier systems are enumerated and discussed. © 2015 Future Science Ltd.