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Joshi H.P.,Dr Reddys Laboratory
International Journal of ChemTech Research | Year: 2011

A simple, rapid, and precise method has been developed for quantitative analysis of Lornoxicam (LXM) in pharmaceutical dosage forms. Chromatographic separation of LXM was achieved on a C18 analytical column with potassium dihydrogen phosphate buffer - acetonitrile, 70:30 (v/v), as mobile phase at ambient temperature. The flow rate was 1.0 ml/min and detection was by absorption at 291 nm using a photodiode-array detector. The number of theoretical plates and tailing factor for LXM were 6,577 and 1.03, respectively. The linearity of the method was excellent over the range 10-100 μg/ ml LXM. The correlation coefficient was 0.9999. Relative standard deviations of peak areas from six measurements were always less than 2%. The proposed method was found to be suitable and accurate for quantitative analysis of LXM.


Chennuru R.,Dr Reddys Laboratory | Maddimsetti B.,Dr Reddys Laboratory | Gundlapalli S.,Gandhi Institute of Technology and Management | Babu R.R.C.,Gandhi Institute of Technology and Management | Mahapatra S.,Dr Reddys Laboratory
Acta Crystallographica Section E: Crystallographic Communications | Year: 2015

In the title compound, C11H6BrClO3, the benzopyran ring system is essentially planar, with a maximum deviation of 0.036 (2) Å for the O atom. The Cl and Br atoms are displaced by -0.0526 (8) and 0.6698 (3) Å, respectively, from the mean plane of this ring system. In the crystal, two pairs of weak C-H···O hydrogen bonds to the same acceptor O atom link molecules into inversion dimers.


Saritha V.,Gandhi Institute of Technology and Management | Anil Kumar K.,Dr Reddys Laboratory | Jyothi V.S.,Gandhi Institute of Technology and Management
Nature Environment and Pollution Technology | Year: 2010

A population-based cross-sectional study was carried out in coastal zone of Visakhapatnam among 170 workers in 41 randomly selected Xerox (photostat) shops. The aim was to evaluate the relations between work with Xerox equipment and the occurrence of eye, nasopharyngeal, skin and general symptoms (often denoted as sick building syndrome (SBS), chronic respiratory symptoms, and respiratory infections. Work with self-copying paper was significantly related to weekly work-related eye, nasopharyngeal and skin symptoms, headache and lethargy, as well as to the occurrence of wheezing, cough, mucus production, sinusitis, and acute bronchitis. Xeroxing was related to nasal irritation, and video display terminal work to eye symptoms, headache, and lethargy.


PubMed | Dr Reddys Laboratory and Gandhi Institute of Technology and Management
Type: Journal Article | Journal: Acta crystallographica. Section E, Crystallographic communications | Year: 2015

In the title compound, C11H6BrClO3, the benzo-pyran ring system is essentially planar, with a maximum deviation of 0.036(2) for the O atom. The Cl and Br atoms are displaced by -0.0526(8) and 0.6698(3), respectively, from the mean plane of this ring system. In the crystal, two pairs of weak C-HO hydrogen bonds to the same acceptor O atom link mol-ecules into inversion dimers.


Sailstad J.M.,NC Associates | Amaravadi L.,Biogen Idec | Clements-Egan A.,Janssen Research and Development Johnson and Johnson | Gorovits B.,Pfizer | And 8 more authors.
AAPS Journal | Year: 2014

The Global Bioanalysis Consortium (GBC) set up an international team to explore the impact of immunogenicity on pharmacokinetic (PK) assessments. The intent of this paper is to define the field and propose best practices when developing PK assays for biotherapeutics. We focus on the impact of anti-drug antibodies (ADA) on the performance of PK assay leading to the impact on the reported drug concentration and exposure. The manuscript describes strategies to assess whether the observed change in the drug concentration is due to the ADA impact on drug clearance rates or is a consequence of ADA interference in the bioanalytical method applied to measure drug concentration. This paper provides the bioanalytical scientist guidance for developing ADA-tolerant PK methods. It is essential that the data generated in the PK, ADA, pharmacodynamic and efficacy/toxicity evaluations are viewed together. Therefore, the extent for the investigation of the PK sensitivity to the presence of ADA should be driven by the project needs and risk based. © 2014 American Association of Pharmaceutical Scientists.


Madhu C.H.,Dr Reddys Laboratory | Tangeda S.J.,Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya | Qarlapati A.,Kakatiya University
Indian Journal of Heterocyclic Chemistry | Year: 2011

Some new benzimidazolyl and benzotriazolyl dithiocarbamates (4a-e & 5a-e) were prepared by reacting corresponding benzimidazoles and benzotriazoles with carbon disulfide and various alkylhalides in dimethylformamide. The newly synthesized compounds were characterized by 1H NMR, MS and elemental analysis. All the compounds have been screened for cytotoxic activity using Trigonella seeds.


Anuradha S.N.,AIMST University | Vilashene G.,Masterskill Global College | Lalithambigai J.,Masterskill Global College | Arunkumar S.,Dr Reddys Laboratory
Asian Journal of Pharmaceutical and Clinical Research | Year: 2015

Cosmeceuticals are the latest addition to the health industry and are described as cosmetic products with drug-like activities. Cosmetics are products that are used to cleanse and beautify the skin (Millikan, 2001). Pharmaceuticals are essentially drug products and are defined as products that prevent, mitigate, treat or cure disease and/or affect the structure or function of the body (Vermeer and Gilchrest, 1996). Cosmeceuticals is a deliberate portmanteau of these two terms and is intended to connote drug-like benefits from an otherwise cosmetic product. While the food, drug, and cosmetic act does not recognize the term “cosmeceutical,” the cosmetic industry has begun to use this word to refer to cosmetic products that have drug-like benefits. The term cosmeceutical was coined by Kilgman, but these lines of product became popular in 1996 and have an expanding market that has rapidly reached Africa. Many scientists and health consumers in Africa may not be conversant with this line of products. They may, therefore, be underresearched or over-utilized. In the cosmetic arena, many materials are used commercially. Cosmetic ingredients previously considered “inert” have the potential to provide a biologic effect to the skin. In a cosmeceutical formulation, the boundary between an “active” and “inert” ingredient may be obscured. There is most common names of the different ingredients used in cosmeceutical products such as antioxidants, the binding agent, emollients, emulsions, humectants, lubricants, preservatives, solvents, surfactants, vehicle, etc. “Potential for cosmeceutical ingredients in the United States alone is SI00 million and includes such products as skin peelers, wrinkle creams, emollients, hair growth stimulants, skin lighteners and darkeners, and botanicals. The 75 million baby boomers are the major market for cosmeceuticals. Cosmeceuticals claims are largely unsubstantiated and the term, though misleading, has probably come to stay. The term and the target consumers appear flamboyant enough to with stand Government regulations. In a free trade world, the benefits and adverse effects of cosmeceuticals are probably optimized by frequent review to inform the clinical and public stake-holders of their uses and limitations. This comprehensive review attempts to briefly, expand the recent knowledge about cosmeceuticals. © 2015 Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.

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