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Rao K.R.,Dr Reddys Laboratories Ltd Miyapur | Mekala R.,Dr Reddys Laboratories Ltd Miyapur | Raghunadh A.,Dr Reddys Laboratories Ltd Miyapur | Meruva S.B.,Dr Reddys Laboratories Ltd Miyapur | And 5 more authors.
RSC Advances | Year: 2015

A remarkably rapid but microwave/ultrasound/catalyst-free method has been developed for the construction of a quinazolin-4(3H)-one ring using formamide as an efficient ammonia precursor and PEG-400 as an effective solvent. The methodology afforded various 2-substituted quinazolin-4(3H)-one derivatives in good yield via a three-component reaction of isatoic anhydride, aldehydes and formamide in air. This single methodology was extended successfully to the synthesis of several alkaloids e.g. leutonin B and E, bouchardatine and 8-norrutaecarpine. © The Royal Society of Chemistry 2015.

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