Mehta V.P.,Dr Reddys Laboratories Bachupally |
Garcia-Lopez J.-A.,University of Murcia
ChemCatChem | Year: 2017
The transition-metal-directed C-H activation processes have traditionally required the installation of suitable coordinating groups to place the metal in close proximity to an specific neighboring or remote C(sp2)-H or C(sp3)-H moiety of the molecular structure. Alternatively, substitution of C-H bonds at positions previously thought inaccessible are now performed through domino processes via insitu generated σ-alkyl-PdII species. This Concept article highlights on recent developments which utilize these σ-alky-PdII-species for remote C-H functionalization to reinvigorate new C-C bond formation in cascade fashion via use of catalytic palladium metal. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.