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Faizabad, India

Avadh University or Awadh University known as Ram Manohar Lohia Avadh University is one of the premier universities in India. It is on NH96 in Faizabad city of Uttar Pradesh province. It was established in 1975 by the government of Uttar Pradesh. Wikipedia.

Jain V.,Dr. Ram Manohar Lohia Avadh University
Journal, Indian Academy of Clinical Medicine | Year: 2013

Knee osteoarthritis (OA) is a disorder of cartilage and periarticular bone. It is a most frequent chronic musculoskeletal disorder and the leading cause of disability in the elderly. The risk factors include genetics, female sex, past trauma, advancing age, and obesity. A plain radiograph may help in the diagnosis of knee OA. The management of OA primarily comprises pharmacological therapy and various non-pharmacological interventions. Total joint replacement of the knee OA is recommended for patients with chronic pain and disability despite maximal medical therapy. This review focuses on the diagnosis, pathogenesis, and treatment based on recent studies. Source

Sharma S.,Indian Institute of Toxicology Research | Singh R.L.,Dr. Ram Manohar Lohia Avadh University | Kakkar P.,Indian Institute of Toxicology Research
Food and Chemical Toxicology | Year: 2011

Oxidative stress is an important factor in drug induced hepatotoxicity and antioxidants from natural sources have potential to ameliorate it. The present study was aimed to investigate cyto-protective potential of probiotic Enterococcus lactis IITRHR1 (ElSN) and Lactobacillus acidophilus MTCC447 (LaSN) lysate against acetaminophen (APAP) induced hepatotoxicity. Cultured rat hepatocytes pretreated with ElSN/LaSN showed higher cell viability under APAP stress. Pre-treatment with ElSN, restored glutathione level and reduced ROS generation significantly which are major biomarkers of oxidative stress. It also reduced NO level, MDA formation and enhanced SOD activity. Pre-treatment with probiotic lysates significantly inhibited the translocation of pro-apoptotic protein (Bax), enhanced anti-apoptotic (Bcl-2) protein levels and prevented release of cyt c to cytosol; suggesting involvement of mitochondrial proteins in protection against APAP induced oxidative cellular damage. Loss in mitochondrial membrane potential due to APAP treatment was prevented in the presence of probiotic lysates. Protective action of ElSN/LaSN pretreatment was further supported by prevention of procaspase-3 activation, DNA fragmentation and chromatin condensation, in turn inhibiting APAP induced apoptotic cell death. The results indicate that probiotic preparations modulate crucial end points of oxidative stress induced apoptosis and may be used for management of drug induced liver injury. © 2010 Elsevier Ltd. Source

Kumar D.,Dr. Ram Manohar Lohia Avadh University | Bagri N.,Banaras Hindu University
Indian Pediatrics | Year: 2015

Pediatric cardiology is outgrowing from the shadows of adult cardiology and cardiac surgery departments in India. It promises to be an attractive and sought-after subspeciality of Pediatrics, dealing with not only congenital cardiac diseases but also metabolic, rheumatic and host of other cardiac diseases. The new government policy shall provide more training avenues for the budding pediatric cardiologists, pediatric cardiac surgeons, pediatric anesthetists, pediatric cardiac intensivists, neonatologists and a host of supportive workforce. The proactive role of Indian Academy of Pediatrics and Pediatric Cardiac Society of India, towards creating a political will at the highest level for framing policies towards building infrastructure, training of workforce and subsidies for pediatric cardiac surgeries and procedures shall fuel the development of multiple tertiary cardiac centers in the country, making pediatric cardiology services accessible to the needy population. © 2015, Indian Academy of Pediatrics. Source

Garg S.K.,Dr. Ram Manohar Lohia Avadh University | Tripathi M.,Dr. Ram Manohar Lohia Avadh University | Srinath T.,Indian Institute of Science
Reviews of Environmental Contamination and Toxicology | Year: 2012

Pollution of the environment by toxic metals results largely from industrial activities, although sources such as agriculture and sewage disposal also contribute to some extent (Nriagu and Pacyna 1989). Toxic metallic species, once mobilized into the environment, tend to persist, circulate, and eventually accumulate at different trophic levels in members of the food chain. Ultimately, metal pollutants pose a serious threat to the environment, and affect plants, animals, and humans (Olson and Foster 1956; Reidske 1956; Sauter et al. 1976; Levis and Bianchi 1982; Mance 1987; Xing and Okrent 1993). Metal pollutants eventually affect ecosystem function, and impose an economic and public health burden. The problems associated with wastewater disposal in developing countries can generally be attributed to lack of adequate treatment/management policies, coupled with ineffective legislation on the part of entrusted governmental agencies (The Environmental Protection Act 1991; Oboh and Aluyor 2008). Environmental awareness has grown among consumers and industrialists in recent decades, and more recently has culminated in legal constraints being imposed on emissions; such constraints have increasingly become more strict necessitating cost-effective emission control (Gadd and White 1993). © 2012 Springer Science+Business Media, LLC. Source

Garg S.K.,Dr. Ram Manohar Lohia Avadh University | Tripathi M.,Dr. Ram Manohar Lohia Avadh University
Reviews of Environmental Contamination and Toxicology | Year: 2011

The potential hazards associated with industrial effluents, coupled with increasing awareness of environmental problems, have prompted many countries to limit the indiscriminate discharge of untreated wastewaters. The pulp and paper industry has been among the most significant of industrial polluters of the waterways, and therefore has been one of the industries of concern. © 2011 Springer Science+Business Media, LLC. Source

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