Dr Pinnamaneni Siddhartha Institute Of Medical Science And Research Foundation
Dr Pinnamaneni Siddhartha Institute Of Medical Science And Research Foundation
Chakravarthi K.K.,Dr Pinnamaneni Siddhartha Institute Of Medical Science And Research Foundation |
Avadhani R.,Mangalore University |
Narayan R.S.,Mangalore University
Drug Invention Today | Year: 2012
Memory is an organism's mental ability to store, retain and recall information. The hippocampus plays an important role in learning and memory. The present study was undertaken to investigate the effects of Glycyrrhiza glabra root extract on learning and memory in three months old male Wistar albino rats. The aqueous extract of root of Glycyrrhiza glabra was administered orally in three doses (75, 150 and 300 mg/kg) for 4 weeks. Elevated plus-maze and Morris water maze tests were conducted to evaluate the learning and memory parameters and served as the exteroceptive behavioral models. Diazepam induced amnesia served as the interoceptive behavioral model. The aqueous extract of root of Glycyrrhiza glabra showed improvement in learning and memory in a dose dependent manner. However in the dose of 150mg/kg it has shown a significant (p<0.01) enhancement in learning and memory which is comparable to control. Hence Glycyrrhiza glabra appears to be a promising drug for improving memory and it would be worthwhile to explore the potential of this plant in the management of impaired learning, dementia, Alzheimer's disease and other neurodegenerative disorders. However, further studies are necessitated to identify the exact mechanism of action.
Gujaria I.J.,Smtbkshah Medical Institute And Research Center |
Salve V.M.,DR Pinnamaneni Siddhartha Institute Of Medical science and Research Foundation
International Journal of Pharma and Bio Sciences | Year: 2012
Cephalic index is the ratio of the maximum breadth of head to its maximum length. cephalic index is very useful anthropologically to find out racial differences. It has also been reported that cephalic index is less than 2-3 in individual with sickle cell anemia than normal individual. Materials and Methods: The present study was carried out at three places Mumbai (Maharashtra), Chinnaoutpalli (Andhra Pradesh) and Ahmedabad (Gujarat). This study was carried on 440 (220 male & 220 female), 420 (210 male & 210 female), 500 (302 male & 198 female) medical students of Mumbai, Chinnaoutpalli and Ahmedabad respectively. Results: The mean cephalic index for Maharashtra populationwas 78.14. The mean cephalic index for Andhra Pradesh population was 77.32. The mean cephalic index for Gujarat population was 80.81. Discussion & conclusion: The result of present study shows that cephalic index of Maharashtra population is almost 1 point higher than Andhra Pradesh population. In Maharashtra and Andhra Pradesh population cephalic index of the female is almost 2 points higher than the male. This study will serve as a basis of comparison for future studies on Maharashtra, Andhra Pradesh and Gujarat population.
Sireesha P.,Manipal Super Speciality Hospitals |
Manoj Kumar C.H.,Manipal Super Speciality Hospitals |
Setty C.R.,Dr Pinnamaneni Siddhartha Institute Of Medical Science And Research Foundation
Indian Journal of Medical Microbiology | Year: 2010
We report a case of thyroid abscess caused by Scedosporium apiospermum in a patient with cirrhosis of liver and autoimmune haemolytic anaemia. To date, there are no reports of isolation of this fungus from thyroid abscess.
Prasad D.K.V.,Osmania University |
Prasad D.K.V.,NTR University of Health Sciences |
Satyanarayana U.,Dr Pinnamaneni Siddhartha Institute Of Medical Science And Research Foundation |
Munshi A.,Osmania University
Neurology India | Year: 2013
Idiopathic generalized epilepsy (IGE) is a common type of epilepsy. Strong support for a genetic role in IGE comes from twin and family studies. Several subtypes of IGE have been reported but families often have members affected with different subtypes. Major advances have been made in the understanding of genetic basis of monogenic inherited epilepsies. However, most IGEs are complex genetic diseases and some susceptible IGE genes are shared across subtypes that determine subtypes in specific combinations. The high throughput technologies like deoxyribonucleic acid microarrays and sequencing technologies have the potential to identify causative genes or loci in non-familial cases.
Shabana S.,Dr Pinnamaneni Siddhartha Institute Of Medical Science And Research Foundation |
Sireesha M.,Dr Pinnamaneni Siddhartha Institute Of Medical Science And Research Foundation |
Satyanarayana U.,Dr Pinnamaneni Siddhartha Institute Of Medical Science And Research Foundation
Journal of Clinical and Diagnostic Research | Year: 2012
Introduction: The role of uric acid in the progression of prediabetes to diabetes has been known. However, conflicting data exist as regards the serum uric acid (UA) levels in type 2 diabetes mellitus, which are associated with risk factors and complications. Objective: The present study was designed to look for any association of serum uric acid with hypertension in type 2 diabetes mellitus, taking into consideration the relevant clinical, biochemical and the anthropometric data. Material and methods: Fifty patients with type 2 diabetes mellitus and 50 healthy controls were included in this study. They were further divided into different groups, based on the sex, the duration of diabetes, and the diabetes which was complicated with hypertension. Results: The circulatory levels of glucose, total cholesterol and triglycerides were found to be elevated in the diabetics of either sex as compared to those in the controls. There was no significant difference in the serum uric acid levels between the diabetics and the non-diabetics, either in males or females. A negative correlation was observed between the fasting plasma glucose and the serum uric acid levels in both male [r = -0.60] and female [r = -0.60] diabetic patients. The serum uric acid levels marginally decreased with an increased duration of diabetes. The hypertensive male and female diabetics were found to have significantly decreased (P < 0.05) serum uric acid levels as compared to the corresponding non-hypertensive diabetics. Conclusion: It was concluded from the present study that there occurs a significant decrease in the serum uric acid levels in hypertensive diabetics (both in males and females) in comparison with the non-hypertensive diabetics.
Parimala N.B.S.,Dr Pinnamaneni Siddhartha Institute of Medical science and Research Foundation
Journal of Clinical and Diagnostic Research | Year: 2013
Renal arteries are a pair of lateral branches which arise from abdominal aorta, just below the origin of the superior mesenteric artery (sma), at L2 level. The right one is longer, on account of position of aorta and left is a little higher in its origin. Variations in renal arteries are highly common and such variations may differ in number, mode of origin, branching, course and termination. Extra renal arteries (ERA) are broadly divided into two types- The aberrant (polar) ones are those which supply the kidney (poles) without passing through hilum, whereas the accessory (hilar) ones are those which supply the kidney after passing through hilum. The renal veins are of large size, which are located anterior to arteries and they open into inferior vena cava at right angles. The left is thrice in length than right one and it passes in front of abdominal aorta to join inferior vena cava (IVC). In view of constantly increasing renal transplantations and kidney retrieval surgeries, the variations in renal vasculature are valuable. Anomalies of renal veins are rarely encountered. Abnormal renal vessels are of interest to the medical and surgical personnel, because of the wide spectrum of diseases which are associated with kidney, like hydronephrosis, left renal vein hypertension, retro peritoneal tumours and surgeries, particularly renal transplantations.
Salve V.M.,Dr Pinnamaneni Siddhartha Institute of Medical science and Research Foundation |
Chandrashekhar C.H.,Dr Pinnamaneni Siddhartha Institute of Medical science and Research Foundation
Journal of the Indian Medical Association | Year: 2012
The human skull has been studied both metrically and non- metrically previously. These studies have thrown light on the functional and morphological aspect of the skull. Cranial index and other cranial indices are useful in differentiation of racial and gender difference. As studies on sexual dimorphism of cranium were very few we have taken this study to find out the differences in cranial index, vertical index and transverse vertical index of male and female crania at Mumbai region. This study was carried out on 210 (150 males and 60 females) dry human skulls available in department of anatomy of four Medical Colleges in Mumbai. The mean and SD of cranial index were 74.23±4.06; for males: 73.19±3.76, and for females: 76.84±3.63. The mean and SD of transverse vertical index were 100.84±6.31; for males: 102.19±6.15, and for females: 97.46±5.41. The difference between cranial index (p=0.000000) and transverse vertical index (p=0.000019) of male and female skulls were significant. The results of the present study show that majority of male skulls of Mumbai region belong to dolicocephalic group and majority of female skulls to mesocephalic. The result of present study shows that majority of male skulls of Mumbai region belong to acrocranial group (based on transverse vertical index). This data can be useful for forensic medicine experts, plastic surgeons, anatomist and oral surgeons for clinical and research purpose.
Salve V.M.,Dr Pinnamaneni Siddhartha Institute Of Medical Science And Research Foundation
Journal of Morphological Sciences | Year: 2012
The "main classic branches" of the coeliac trunk are hepatic, splenic and left gastric arteries. The present variation was observed during the abdomen dissection classes for the medical under graduates, in the Department of Anatomy at Dr. Pinnamaneni Siddhartha Institute of Medical Sciences & Research Foundation, Gannavaram Mandal, Krishna District (AP), (INDIA), and a 52 year old male cadaver showed the coeliac trunk and superior mesenteric artery arose as common trunk from the ventral surface of the abdominal aorta at the level of the L1 vertebra. The coeliacomesenteric trunk is the rare variation. The incidence of coeliacomesenteric trunk variation was reported to be 2.7% by Parnanen and 1% by both Munger and Eaton. Complications in abdominal surgeries could be avoided with the accurate knowledge of the anatomical variations of coeliac trunk and superior mesenteric artery.
Tripuraneni S.C.,Dr Pinnamaneni Siddhartha Institute of Medical science and Research Foundation
Clinical Rhinology | Year: 2012
Melanotic neuroectodermal tumor of infancy (MNTI) is a relatively uncommon osteolytic-pigmented neoplasm that primarily affects the jaws of newborn infants. Here, we are reporting a case of MNTI presented at the age of 12 years. The objective of this report is to review the incidence, presentation, investigation protocols, management options and outcomes.
Sireesha P.,Dr Pinnamaneni Siddhartha Institute Of Medical Science And Research Foundation |
Setty C.,Dr Pinnamaneni Siddhartha Institute Of Medical Science And Research Foundation
Indian Journal of Medical Microbiology | Year: 2012
Purpose: The macrolide lincosamide streptogramin B (MLS B ) family of antibiotics serves as an alternative for the treatment of skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA). However, resistance to clindamycin too has emerged, which is of two types, inducible and constitutive. Therapeutic failure is common with inducible type of clindamycin resistance. This study was done to determine the various clindamycin resistance patterns in MRSA isolates and to compare them with minimal inhibitory concentration (MIC) of clindamycin. Materials and Methods: Fifty MRSA isolates were studied by disc approximation test (D test) to detect inducible iMLS B resistance and MIC by agar dilution technique. Results: Of the 50 isolates, 34 were sensitive to both clindamycin and erythromycin. 16 isolates showed different sensitivity patterns; nine of these were positive for D zone indicating inducible iMLS B resistance, five were positive for constitutive MLS B resistance and two showed possible efflux mechanism for macrolide resistance. Out of the 34 sensitive isolates, 5 showed isolated colonies (subpopulation) inside the clindamycin-sensitive zone. When these sub-populations were tested further, two were constitutive MLS B phenotypes, two were inducible iMLS B and one was HD (hazy D zone), which is D + with growth up to clindamycin disc (which is also considered as constitutive MLS B phenotype). Seven isolates showed an MIC of 4 g/ml to clindamycin in spite of being susceptible to both erythromycin and clindamycin by Kirby Bauer disc diffusion technique. Out of these seven isolates, five were those which grew as subpopulation inside the clindamycin-sensitive zone. Conclusion: Detection of iMLS B resistance among MRSA helps to avoid treatment failure with clindamycin. Studying the subpopulation inside the clindamycin-sensitive zone raises the question of existence of hetero-resistance or some other mechanism, which needs further study.