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Murthy V.K.,Dr Pinnamaneni Siddartha Institute Of Medical Science And Research Foundation | Prakash V.,SFPAA Research Institute | Kiran V.S.R.,Alluri Sitarama Raju Academy of Medical science | Rao S.V.,Katuri Medical College
Biomedicine (India) | Year: 2012

Background and Objectives: Patients with diabetes mellitus are at increased risk for myocardial infarction. A comparative study of Apo-B/Apo-A1, total cholesterol/HDLc, HDLc/LDLc, and TAG/HDLc ratios for the prediction of cardiovascular risk was done between type-1, type-2 diabetes mellitus and healthy controls. Methods: A known 46 type-1 and 46 type-2 diabetes mellitus patients were selected for the study. A 46 healthy controls were also included in the study. In all the subjects Apo-B/Apo-A1, total cholesterol/HDLc, HDLc/LDLc, and TAG/HDLc ratios were studied. ANOVA statistics was done to compare mean values between the three groups. Results: Present study showed that Apo-B/Apo-A1 ratio was increased in both type-1 and type-2 diabetes mellitus. It was found that total cholesterol/HDLc, HDLc/LDLc, and TAG/HDLc ratios were increased in both type-1 and type-2 diabetes mellitus when compared to controls. Furthermore the increase was very much in type-2 than type-1 diabetes mellitus followed by controls respectively. Interpretation and Conclusion: Present study showed that all the ratios were abnormally increased in both type-1 and type-2 diabetes mellitus suggesting a risk for cardiovascular disease. The increase was severe in type-2 than type-1 diabetes mellitus predicting a higher risk for type-2 diabetes mellitus than type-1 diabetes mellitus for cardiovascular disease. Source

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