Dr. MACS Bio Pharma Pvt. Ltd.

Kūkatpalli, India

Dr. MACS Bio Pharma Pvt. Ltd.

Kūkatpalli, India
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Ruddarraju R.R.,Dr.MACS Bio Pharma Pvt. Ltd. | Murugulla A.C.,Dr.MACS Bio Pharma Pvt. Ltd. | Kotla R.,Dr.MACS Bio Pharma Pvt. Ltd. | Tirumalasetty M.C.B.,Sri Venkateswara University | And 3 more authors.
MedChemComm | Year: 2017

A new series of theophylline analogues containing 1,2,3-triazoles with different amide groups (22-41) has been designed and synthesized, and their biological activities have been evaluated as potential anticancer agents. The anticancer activities of the synthesized compounds were studied in four cancer cell lines viz. lung (A549), colon (HT-29), breast (MCF-7) and melanoma (A375). Furthermore, these compounds were screened for computational ADME and Lipinski's analysis followed by molecular docking and binding energy calculations against the various therapeutic targets involved in cell proliferation. The in vitro results demonstrate that compounds 22, 27, 36 and 40 have pivotal anticancer activity. Among these, compounds 22 and 27 have significant cytotoxic activity in all three cell lines; the in silico docking studies also reveal that compounds 22, 27 and 36 have good dock scores, binding affinities and binding energies towards human epidermal growth factor receptor 2. This is the first report to demonstrate theophylline hybrids containing 1,2,3-triazoles as potential anticancer agents. © The Royal Society of Chemistry.

Gangarapu K.,Anurag Group of Institutions | Gangarapu K.,Dr. Macs Bio Pharma Pvt Ltd | Manda S.,Kakatiya University | Jallapally A.,Dr. Macs Bio Pharma Pvt Ltd | And 2 more authors.
Medicinal Chemistry Research | Year: 2017

Cancer, which is considered to be the world’s most serious illness cause 8.2 million deaths and this rate may double by 2030. We herein report a new series of 3-(2-(p-substituted)-2-((5-phenyl-1,3,4-thiadiazol-2-yl)imino)-2-(p-substituted)ethylidene)indolin-2-one (15–19) and 5-substituted-5′-substituted phenyl-2′,4′-dihydrospiro[indoline-3,3′-pyrazol]-2-one derivatives (20–24) as potent anticancer agents. These compounds were evaluated for in vitro antitumor activity against the National Cancer Institute panel of 60 cancer cell lines. Among all the synthesized compounds, two compounds 15 and 16 showed remarkable antitumor activity with GI50 (MG-MID) values of 0.65 & 0.72 µM, respectively against Non-small cell lung cancer. To gain insight for mode of binding with Epidermal Growth Factor Receptor kinase enzyme, these compounds were further subjected to docking studies. © 2017 Springer Science+Business Media New York

Reddy N.S.,GVK Biosciences Pvt Ltd | Reddy N.S.,Sudan University of Science and Technology | Rao A.S.,GVK Biosciences Pvt Ltd | Chari M.A.,Dr. MACS Bio Pharma Pvt. Ltd. | And 4 more authors.
Journal of Chemical Sciences | Year: 2012

Synthesis and antibacterial activity of some novel biologically active sulfonamide derivatives at C-8 alkyl chain of anacardic acid (7a-7l), prepared from commercially available anacardic acid mixture (1a-d). These compounds were tested for Gram positive and Gram negative bacterial cultures; most of the compounds showed higher antibacterial activity compared with standard drug ampicillin. © Indian Academy of Sciences.

Adharvana Chari M.,Jawaharlal Nehru University | Adharvana Chari M.,Dr. MACS Bio Pharma Pvt. Ltd. | Shobha D.,Dr. MACS Bio Pharma Pvt. Ltd. | Prakash K.M.M.S.,Dr. MACS Bio Pharma Pvt. Ltd. | Syamasundar K.,Jawaharlal Nehru University
Asian Journal of Chemistry | Year: 2012

Metal complexes of divalent d-block metal ions with different thiosemicarbazones have been synthesized. These thiosemicarbazone ligands forms complexes with iron(II), cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and mercury(II). The structural study of the complexes have been characterized by elemental analysis, conductance, IR, NMR and Mass spectral data. The physico-chemical and spectral data suggests octahedral and tetrahedrol geometry for various complexes. The ligand and metal chelates have been screened in vitro for antimicrobial activity against some of the fungal and bacterial. The screening have revealed that metal complexes exhibit enhanced activity than their parent ligand-against both the fungal and bacterial strains used.

Shobha D.,Dr. MACS Bio Pharma Pvt. Ltd | Shobha D.,Jawaharlal Nehru University | Chari M.A.,Dr. MACS Bio Pharma Pvt. Ltd | Chari M.A.,Kyung Hee University | And 2 more authors.
Tetrahedron Letters | Year: 2012

We demonstrate the synthesis of multifunctional 3,4-dihydroquinoxalin-2- amine derivatives 4 through a three-component condensation reactions of a substituted o-phenylenediamines 1 (OPDA), diverse ketones 2 and various isocyanides 3 in the presence of a catalytic amount of p-toluenesulfonic acid (PTSA) affording excellent yields (82-96%) and 10 mol % of silica gel supported sulfuric acid with good yields (85-98%) in ethanol at room temperature (2-4 h). We also carried out the anti-neuroinflammatory activity of 3,4- dihydroquinoxalin-2-amine derivatives and some of the compounds exhibited good activity. © 2012 Elsevier Ltd. All rights reserved.

Adharvana Chari M.,Dr. MACS Bio Pharma Pvt. Ltd. | Adharvana Chari M.,University of Tokyo | Shobha D.,Dr. MACS Bio Pharma Pvt. Ltd. | Shobha D.,University of Tokyo | And 3 more authors.
Asian Journal of Chemistry | Year: 2012

Molybdenum(V)chloride catalyzes efficiently the three component condensation reaction of aldehyde, β-ketoester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones (DHPMs). Compared to the classical Biginelli reaction conditions, this new approach consistently has the advantage of excellent yields (80-91 %) and short reaction times 1.4-2.6 h.

Purandhar K.,Matrix | Chari M.A.,Dr. MACS Bio Pharma Pvt. Ltd. | Reddy P.P.,Macleods Pharmaceuticals Ltd | Mukkanti K.,Jawaharlal Nehru Technological University
Letters in Organic Chemistry | Year: 2014

An efficient method has been developed for the synthesis of substituted 1,5-benzoxazepines and benzothiazepines under classical heating conditions or microwave irradiation in the presence of an efficient and reusable Potassium Dodecatungstocobaltate Trihydrate (PDTC, K5CoW12O 40.3H2O) as heterogeneous catalyst which was found to be highly active and afforded excellent yields. The products 6,8,9 and 10 were synthesized using the starting compounds 4a-d, 1 mol% PDTC and achieved in good yields by reflux (70-80%) as well as microwave conditions (60-70%). The reactions of 17a-e with 7, in the presence of 1 mol % PDTC were refluxed in dry ethanol for 6-8 h to isolate the compounds 18a-e in good yields (70-85%) as syrups. © 2014 Bentham Science Publishers.

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