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Chaudhary A.,Subharti University | Sharma P.P.,Gurukul Kangri University | Bhardwaj G.,IILM College | Jain V.,National Institute of Pharmaceutical Education and Research | And 3 more authors.
Medicinal Chemistry Research | Year: 2013

Two novel series of heterocyclic compounds have been synthesized. In first series, isatin was allowed to react with substituted aromatic/cyclic carbonyl compounds to get desired mannich bases (2a-e). In second series, 4,5-disubstituted oxazoles (6a-p) were synthesized. Eight compounds (2c, 6a, 6e, 6f, 6i, 6j, 6m, and 6n) were screened for anticancer activity in 60 cell lines. Compound 2c, 1-[(4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptan-2-yl)methyl] indoline-2,3-dione, showed maximum activity and thus, selected for further evaluation at five dose level screening. Furthermore, molecular docking studies of compounds 2c into the colchicine-binding site of tubulin, revealed possible mode of inhibition by the compound. © 2013 Springer Science+Business Media New York.


Sivakumar S.M.,Jazan University | Kannadasan M.,Dr Kn Modi Institute Of Pharmaceutical Education And Research | Roy R.K.,Dr Kn Modi Institute Of Pharmaceutical Education And Research
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

Chitosan has wide range of applications in biomedicine, pharmaceuticals, cosmetics, agriculture etc. Due to non toxic, biocompatible, biodegradable, high charge density and muco adhesion properties has been found potential applications in pharmaceuticals. Polymers used in controlled drug/biological delivery system have become more sophisticated. Over the past few decades there has been increase in progress of developing controlled delivery system in order to reduce systemic toxicity and to improve patient compliance. Chitosan polymer has emerged as an one of the potential natural polymer to fabricate nanoparticles, microparticles, hydrogels, tablets, implants etc. This review article is an attempt to highlight the applications of chitosan polymer in pharmaceuticals in brief.


Semwal D.K.,Hemwati Nandan Bahuguna Garhwal University | Rawat U.,Hemwati Nandan Bahuguna Garhwal University | Semwal R.,Dr Kn Modi Institute Of Pharmaceutical Education And Research | Singh R.,Punjabi University | Singh G.J.P.,University of Punjab
Journal of Asian Natural Products Research | Year: 2010

A palmatine derivative, named 11-hydroxypalmatine (4), has been isolated from the tubers of Stephania glabra, together with three known alkaloids, palmatine (1), dehydrocorydalmine (2), and stepharanine (3). The structures of the compounds were elucidated by means of spectroscopic analysis including 2D NMR experiments. The hypoglycemic activity of 4 was evaluated against alloxan-induced diabetic mice. The test compound was administered at doses of 25, 50, and 100mg/kg, p.o., 36h after alloxan injection (60mg/kg, i.v.). The alloxan-induced diabetic mice showed significant reduction in blood glucose after treatment with the test compound by 52% as compared to the positive control glibenclamide (54%) and the diabetic control (27%).


Kannadasan M.,University of Rajasthan | Sharma V.K.,Dr Kn Modi Institute Of Pharmaceutical Education And Research | Yadav S.,Dr Kn Modi Institute Of Pharmaceutical Education And Research
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Development of nanoparticles and nanotechnologies are currently one of the most active research fields worldwide. Several industrialized countries are making it a strategic priority for sustainable technological, economic and societal development. Nanoparticles provide massive advantages regarding drug targeting, delivery and release and, with their additional potential to combine diagnosis and therapy, emerge as one of the major tools in nanomedicine. In this regard these reviews elaborate the methods of nanotechnologies and types of nanoparticles with their features and future challenges with opportunities. Moreover, in future nanoparticles only provide many diseased as well as much more applications in the world without doubt.


Semwal R.,Dr Kn Modi Institute Of Pharmaceutical Education And Research | Semwal D.K.,Hemwati Nandan Bahuguna Garhwal University | Badoni R.,Hemwati Nandan Bahuguna Garhwal University | Gupta S.,A And G Pharmaceutical, Inc. | Madan A.K.,Md University
Journal of Medical Sciences | Year: 2010

Encouraged by rapid and promising progress in cancer nanotechnology, researchers continue to develop novel and efficacious nanoparticles for drug delivery. The interest in self-assembling polymeric nanoparticles as drug delivery vehicles is growing now a day, in which polymers can lead to supramolecular systems and is related to their functions as carrier for targeting the various cytotoxic drugs. This review article gives the idea of selection, preparation, morphology, stability and drug release characteristics of self-assembled polymeric systems. The release characteristic of drugs from these polymeric systems is dependent on the drug loading contents and chain length of the hydrophobic/hydrophilic part of the copolymers. The review also focuses the recent advances in self-assembled polymeric system.


Pandeya S.N.,Dr Kn Modi Institute Of Pharmaceutical Education And Research
Mini reviews in medicinal chemistry | Year: 2014

1,2,4-Triazine nucleus is a prominent structural core system present in numerous pharmacologically active compounds. Till date, various 1,2,4-triazine analogs, possesing a wide range of potent pharmacological activities, have been reported. This review is an attempt to compile the medicinal chemistry aspects of various synthesized 1,2,4-triazine analogs reported so far.


PubMed | Dr Kn Modi Institute Of Pharmaceutical Education And Research
Type: Journal Article | Journal: Mini reviews in medicinal chemistry | Year: 2014

1,2,3-Triazine is an interesting class of heterocyclic compounds. Various synthetic analogs of 1,2,3-triazine have been prepared and evaluated for many pharmacological activities in different models with desired findings. Some analogs have shown potent pharmacological activity and may be considered as lead molecule for the development of future drugs. This review is an attempt to organize the chemical and pharmacological aspects of 1,2,3-triazine analogs reported till date systematically since 1970.

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