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Nazeerullah K.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Sunil K.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Sunil K.,Jaipur National University | Pal S.R.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Neelam D.,Jaipur National University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Caesalpinia bonducella (L.) Fleming (Syn. Caesalpinia bonduc (L.) Roxb, Syn. Caesalpinia cristaLinn.), belonging to the family Caesalpiniaceae, is a prickly shrub widely distributed all over the world specially in India, Sri Lanka and Andaman and Nicobar Islands, in India specially found in tropical regions. All parts of the plant have medicinal properties so it is a very valuable medicinal plant which is utilized in traditional system of medicine. The plant has been reported to possess anxiolytic, antinociceptive, antidiarrhoeal, antidiabetic, adaptogenic, anthelmintic, antiestrogenic, anti- inflammatory, antimalarial, antimicrobial, antifungal, antispasmodic, antioxidant, antiproliferative, antipsoriatic, antitumor, larvacidal, muscle contractile, hepatoprotective, anticonvulsant and antifilarial activities. Phytochemical analysis of seeds of Caesalpinia bonducella has revealed the presence of alkaloids, flavonoids, glycosides, saponins, tannins and triterpenoids.


Nazeerullah K.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Sunil K.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Sunil K.,Jaipur National University | Pal S.R.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Neelam D.,Jaipur National University
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

Nothapodytes nimmoniana (Graham) belonging to family icacinaceae is commonly known as Amruta and locally as Maharashtra, Goa, Kerala, Karnataka, Assam, Tamilnadu in India. It is an important medicinal plant used in various types of cancer, for HIV, in malaria and antibacterial activity. As the herb is used widely in the Indian traditional system, it was thought worthwhile to undertake the standardization of its leaves, stem and root parts. Aerial parts consist mainly of leaves that are simple, alternate, spiral, clustered at twig ends, petiole 1.2-6 cm long, flat above, puberulous, lamina 9-30 x 5-14 cm, flowers are yellowish, in terminal cymes, emitting an unpleasant odour. In the powdered form it had unpleasant odour and exceedingly sweet taste, fruit Drupe, purplish red, smooth, oblong, 1.5-1.8 cm. Microscopical examination of powder of aerial parts showed fragments of epidermis, glandular trichomes, stone cells, lignified xylem elements, anomocytic stomata and abundant calcium oxalate crystals. Successive extractive value was highest in aqueous extract (35% on dry weight basis). Mean ash values (%) were 2.50 (total), 0.05 (acid insoluble ash) and 1.29 (water soluble ash) are lowest in stem and greater in leaf. Loss on drying was found to be 8.34% and pH values of aqueous extract was 6.50. Foaming index was less than 100. Screening of all extracts indicated the presence of all phytoconstituents except resin. TLC fingerprints of extracts of all parts were also developed. The proposed parameters presented in this paper may help to establish the authenticity of drug, differentiate the drug from other camptothecin containing species and drawing the pharmacopoeial standards for this species.


Kumar D.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Sharma V.K.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Kumar R.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Singh T.,Dr K N Modi Institute Of Pharmaceutical Education And Research | And 3 more authors.
EXCLI Journal | Year: 2013

A series of 5,7-dibromoisatin semicarbazones have been synthesized in good yield, involving aryl urea and aryl semicarbazide formation. The structures of the synthesized compounds were confirmed on the basis of their spectral data. All the compounds were evaluated for anti-convulsant and CNS depressant activities. Anticonvulsant activity was determined after intra-peritoneal (i.p.) administration to mice by maximal electroshock (MES) induced seizure method and minimal motor impairment was determined by rotarod test. A computational study was carried out for prediction of pharmacokinetic properties and making them potentially promising agents for the treatment of epilepsy. Compounds (Z)-1-(5,7-dibromo-2-oxo-indolin-3-ylidene)-4-(4-chlorophenyl)semicarbazide (DH-05), (Z)-1-(5,7-dibromo-2-oxoindo-lin-3-ylidene)-4-(3-chloro-4-fluorophenyl)semicarbazide (DH-11) and (Z)-1-(5,7-dibromo-1-methyl-2-oxoindolin-3-ylidene)-4-(3-chloro-4-fluorophenyl)semicarbazide (DH-12) exhibited prominent anticonvulsant effect in the series with little or no neurotoxicity and little CNS depressant effect as compared to standard drug.


Gupta D.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Kumar R.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Roy R.K.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Sharma A.,Dr K N Modi Institute Of Pharmaceutical Education And Research | And 2 more authors.
Medicinal Chemistry Research | Year: 2013

Epilepsy is the most common neurological disorder known, affecting around 1 % of the world's population, characterized by recurrent seizure attack. A new series of 2-phenyl-3-(3-(substituted-benzylideneamino)-quinazolin-4(3H)-one derivatives (6a-h) was synthesized through condensation of anthranilic acid (1) and benzoyl chloride to give 2-phenyl-benzo[d][1,3]oxazin-4-one (2). Compound 2 was refluxed with hydrazine hydrate and yielded intermediate 3. Further, the intermediate 3 was dehydrated with catalytic amount of GAA and yielded 3-amino-2-phenyl-1H-quinazolin-4-one (4). Compound 4 was further treated with 3-hydroxy benzaldehyde and small amount of GAA to afford schiff base derivative 5. Finally, the Schiff base was treated with various alkyl halide to provide desired compounds 6a-h and structures of the final compounds were confirmed on the basis of their FTIR, NMR, and Mass spectral data. Anticonvulsant activity was evaluated by the maximal electroshock test, further their minimum motor impairment and CNS depressant effect were evaluated by the rotorod motor impairment and Porsolt's force swim tests, respectively. The results showed that 2-phenyl-3-(3-(propoxybenzylideneamino)-3H-quinazolin-4-one (6c) is the most promising compound with the lowest side effects. © 2012 Springer Science+Business Media New York.


Tiwari P.,Dr K N Modi Institute Of Pharmaceutical Education And Research
Research Journal of Pharmacy and Technology | Year: 2014

In the present investigation, different types of test preparations of Balarishta as Balarishta-T, Balarishta-M prepared by traditional and modern methods respectively and marketed Balarishta were evaluated for antimicrobial activity against common human pathogens. It was observed that all the test preparations of Balarishta exhibited significant zone of inhibition against selected common human pathogens. The results indicate that all the test preparations of Balarishta as Balarishta-T, Balarishta-M and marketed Balarishta might be used as natural drug for the treatment of several infectious diseases caused by these organisms. © 2014 RJPT All right reserved.


Sharma P.,Dr K N Modi Institute Of Pharmaceutical Education And Research
International Journal of Pharma and Bio Sciences | Year: 2014

Staphylococcal infections are a group of infections caused by the bacterium Staphylococcus but most infections are caused by a type called Staphylococcus aureus. Bacteria are constantly evolving because their genes are constantly changing. The result of this is that some of the bacteria develop more resistance to a certain antibiotic than others. Methicillin-resistant Staphylococcus aureus is a strain of Staphylococcus aureus who developed resistance to methicillin and is responsible for several infections in humans which cannot be treated easily. It is resistant to many antibiotics and is called as multidrug-resistant Staphylococcus aureus and oxacillin-resistant Staphylococcus aureus. MRSA have resistance because of the widespread use of antibiotics, genetic selection and our dislike of tablets. Most MRSA infections are skin infections but it is also responsible for life-threatening bloodstream infections, pneumonia and surgical site infections. In the present study, a total number of 21 respiratory/sputum samples were collected and screened for methicillin resistant Staphylococcus aureus by biochemical and antibiotic sensitivity tests. Out of 21 samples, 10 were observed as methicillin resistant Staphylococcus aureus. It was found that MRSA shows highly variable antibiotic resistance. All MRSA shows 100% resistance to penicillin but were recorded sensitive to vancomycin. Thus penicillin and methicillin were not found to be effective against MRSA. The study suggests that vancomycin may be used as the drug of choice for treating multidrug resistant MRSA infections.


Kumar R.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Singh T.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Singh H.,Dr K N Modi Institute Of Pharmaceutical Education And Research | Jain S.,Guru Jambheshwar University of Science and Technology | Roy R.K.,Dr K N Modi Institute Of Pharmaceutical Education And Research
EXCLI Journal | Year: 2014

A new series of 6,8-halo-substituted-2H-[1,2,4]triazino[5,6-b]indole-3(5H)-one/-thione and 6,8-halo-substituted 5-methyl-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one/-thione (5a-5l) were designed and synthesized keeping in view of the structural requirement of pharmacophore. The above compounds were characterized by thin layer chromatography and spectral analysis. Anticonvulsant activity of the synthesized compounds was evaluated by the maximal electroshock (MES) test. Neurotoxicity and CNS depressant effects were evaluated by the rotarod motor impairment and Porsolt's force swim tests, respectively. A computational study was carried out, for calculation of pharmacophore pattern, prediction of pharmacokinetic properties and toxicity properties. The above study revealed that the compounds 8-chloro-2H- [1,2,4]triazino[5,6-b]indol-3(5H)-one (5e), 6,8-dibromo-2H-[1,2,4]triazino[5,6-b]indol- 3(5H)-one (5i) and 6,8-dibromo-5-methyl-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one (5k) possess excellent anticonvulsant activity in the series with little CNS depressant effect and no neurotoxicity as compared to standard drugs phenytoin and carbamazepine.


PubMed | Guru Jambheshwar University of Science and Technology and Dr K N Modi Institute Of Pharmaceutical Education And Research
Type: | Journal: EXCLI journal | Year: 2015

A new series of 6,8-halo-substituted-2H-[1,2,4]triazino[5,6-b]indole-3(5H)-one/-thione and 6,8-halo-substituted 5-methyl-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one/-thione (5a-5l) were designed and synthesized keeping in view of the structural requirement of pharmacophore. The above compounds were characterized by thin layer chromatography and spectral analysis. Anticonvulsant activity of the synthesized compounds was evaluated by the maximal electroshock (MES) test. Neurotoxicity and CNS depressant effects were evaluated by the rotarod motor impairment and Porsolts force swim tests, respectively. A computational study was carried out, for calculation of pharmacophore pattern, prediction of pharmacokinetic properties and toxicity properties. The above study revealed that the compounds 8-chloro-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one (5e), 6,8-dibromo-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one (5i) and 6,8-dibromo-5-methyl-2H-[1,2,4]triazino[5,6-b]indol-3(5H)-one (5k) possess excellent anticonvulsant activity in the series with little CNS depressant effect and no neurotoxicity as compared to standard drugs phenytoin and carbamazepine.


PubMed | Dr K N Modi Institute Of Pharmaceutical Education And Research
Type: | Journal: EXCLI journal | Year: 2015

A series of 5,7-dibromoisatin semicarbazones have been synthesized in good yield, involving aryl urea and aryl semicarbazide formation. The structures of the synthesized compounds were confirmed on the basis of their spectral data. All the compounds were evaluated for anticonvulsant and CNS depressant activities. Anticonvulsant activity was determined after intraperitoneal (i.p.) administration to mice by maximal electroshock (MES) induced seizure method and minimal motor impairment was determined by rotarod test. A computational study was carried out for prediction of pharmacokinetic properties and making them potentially promising agents for the treatment of epilepsy. Compounds (Z)-1-(5,7-dibromo-2-oxoindolin-3-ylidene)-4-(4-chlorophenyl)semicarbazide (DH-05), (Z)-1-(5,7-dibromo-2-oxoindolin-3-ylidene)-4-(3-chloro-4-fluorophenyl)semicarbazide (DH-11) and (Z)-1-(5,7-dibromo-1-methyl-2-oxoindolin-3-ylidene)-4-(3-chloro-4-fluorophenyl)semicarbazide (DH-12) exhibited prominent anticonvulsant effect in the series with little or no neurotoxicity and little CNS depressant effect as compared to standard drug.

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