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Semwal R.,Dr Kn Modi Institute Of Pharmaceutical Education And Research | Semwal D.K.,Hemwati Nandan Bahuguna Garhwal University | Badoni R.,Hemwati Nandan Bahuguna Garhwal University | Gupta S.,A And G Pharmaceutical, Inc. | Madan A.K.,Md University
Journal of Medical Sciences

Encouraged by rapid and promising progress in cancer nanotechnology, researchers continue to develop novel and efficacious nanoparticles for drug delivery. The interest in self-assembling polymeric nanoparticles as drug delivery vehicles is growing now a day, in which polymers can lead to supramolecular systems and is related to their functions as carrier for targeting the various cytotoxic drugs. This review article gives the idea of selection, preparation, morphology, stability and drug release characteristics of self-assembled polymeric systems. The release characteristic of drugs from these polymeric systems is dependent on the drug loading contents and chain length of the hydrophobic/hydrophilic part of the copolymers. The review also focuses the recent advances in self-assembled polymeric system. Source

Pandeya S.N.,Dr Kn Modi Institute Of Pharmaceutical Education And Research
Mini reviews in medicinal chemistry

1,2,4-Triazine nucleus is a prominent structural core system present in numerous pharmacologically active compounds. Till date, various 1,2,4-triazine analogs, possesing a wide range of potent pharmacological activities, have been reported. This review is an attempt to compile the medicinal chemistry aspects of various synthesized 1,2,4-triazine analogs reported so far. Source

Chaudhary A.,Subharti University | Sharma P.P.,Gurukul Kangri University | Bhardwaj G.,IILM College | Jain V.,National Institute of Pharmaceutical Education and Research | And 3 more authors.
Medicinal Chemistry Research

Two novel series of heterocyclic compounds have been synthesized. In first series, isatin was allowed to react with substituted aromatic/cyclic carbonyl compounds to get desired mannich bases (2a-e). In second series, 4,5-disubstituted oxazoles (6a-p) were synthesized. Eight compounds (2c, 6a, 6e, 6f, 6i, 6j, 6m, and 6n) were screened for anticancer activity in 60 cell lines. Compound 2c, 1-[(4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptan-2-yl)methyl] indoline-2,3-dione, showed maximum activity and thus, selected for further evaluation at five dose level screening. Furthermore, molecular docking studies of compounds 2c into the colchicine-binding site of tubulin, revealed possible mode of inhibition by the compound. © 2013 Springer Science+Business Media New York. Source

Semwal D.K.,Hemwati Nandan Bahuguna Garhwal University | Rawat U.,Hemwati Nandan Bahuguna Garhwal University | Semwal R.,Dr Kn Modi Institute Of Pharmaceutical Education And Research | Singh R.,Punjabi University | Singh G.J.P.,University of Punjab
Journal of Asian Natural Products Research

A palmatine derivative, named 11-hydroxypalmatine (4), has been isolated from the tubers of Stephania glabra, together with three known alkaloids, palmatine (1), dehydrocorydalmine (2), and stepharanine (3). The structures of the compounds were elucidated by means of spectroscopic analysis including 2D NMR experiments. The hypoglycemic activity of 4 was evaluated against alloxan-induced diabetic mice. The test compound was administered at doses of 25, 50, and 100mg/kg, p.o., 36h after alloxan injection (60mg/kg, i.v.). The alloxan-induced diabetic mice showed significant reduction in blood glucose after treatment with the test compound by 52% as compared to the positive control glibenclamide (54%) and the diabetic control (27%). Source

Sivakumar S.M.,Jazan University | Kannadasan M.,Dr Kn Modi Institute Of Pharmaceutical Education And Research | Roy R.K.,Dr Kn Modi Institute Of Pharmaceutical Education And Research
Research Journal of Pharmaceutical, Biological and Chemical Sciences

Chitosan has wide range of applications in biomedicine, pharmaceuticals, cosmetics, agriculture etc. Due to non toxic, biocompatible, biodegradable, high charge density and muco adhesion properties has been found potential applications in pharmaceuticals. Polymers used in controlled drug/biological delivery system have become more sophisticated. Over the past few decades there has been increase in progress of developing controlled delivery system in order to reduce systemic toxicity and to improve patient compliance. Chitosan polymer has emerged as an one of the potential natural polymer to fabricate nanoparticles, microparticles, hydrogels, tablets, implants etc. This review article is an attempt to highlight the applications of chitosan polymer in pharmaceuticals in brief. Source

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