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Roldan C.,University of Granada | De La Torre A.,University of Granada | Mota S.,University of Granada | Morales-Soto A.,University of Granada | And 2 more authors.
Food Chemistry

We propose a method identifying candidates for active compounds in vegetal extracts. From a collection of samples, the method requires, for each sample, a HPLC-MS analysis and a measurement of the activity. By applying a correlation analysis between the activity and the chromatographic area for each interval of elution time and m/z ratio, the peaks corresponding to candidates for active compounds can be identified. Additionally, when peaks are identified, a model can be estimated to predict the activity in new samples. Both methods are evaluated in one experiment involving the phenolic extract (PE) from 22 samples of extra virgin olive oil (EVOO) where the activity is a cytotoxicity index against JIMT-1 breast cancer cells. In this experiment, the samples were separated into two disjunct partitions: one was used for training (identification of candidates and estimation of prediction model), while the other was used for validation (by comparing the predicted and the measured activities). Three compounds were identified as candidates to be responsible for the cytotoxicity of the EVOO-PE against JIMT-1 cells. The prediction model provided an accurate estimation of the activity. © 2012 Elsevier Ltd. All rights reserved. Source

Objectives: To identify the sample of choice for glycemic control in the critically ill patient; To distinguish the necessary controls to ensure the correct levels of glucose in the critically ill patient; To determine the range of blood glucose values suitable for the critically ill patient. Methods: This review was made in different databases: MEDLINE with the assistance of specific search PubMed and ProQuest, CUIDEN-PLUS and ELSEVIER Publishing website. Results: 24 articles were collected: descriptive, analytic and cohort studies, and also literature reviews. The golden sample for the glucose determination in this patient is the arterial one, and can be also used the venous one, excluding the capillary sample. The analysis should be carried out in a clinical laboratory. However, glucometers can be used to provide instantaneous measurements. Blood glucose controls in the critically ill patient are initially set each hour until their stabilization, and then, they are spaced to periods of two-three hours. The glycemic index is moderate, with values between 140-180. mg/dl. Conclusions: The arterial sample is the chosen one for glucose determination in this patient. Blood glucose controls should be initially set each hour, until their stabilization, and then they are spaced to periods of two-three hours. The glycemia in the critically ill patient should be included in a index of 140-180. mg/dl, which is considered a moderate control. © 2014 Elsevier España, S.L.U. y SEEIUC. Source

Sunyer Esquerra N.,Hospital Universitario Of Girona Dr Josep Trueta | De La Paz Canizares I.,Hospital Universitario Of Girona Dr Josep Trueta | Martinez Sanchez B.,University of Girona | Butina Agusti Maria T.,University of Barcelona
Atencion Farmaceutica

The objective of the study is to analyse adverse reactions to the treatment of chronic hepatitis virus C with Ribavirin and peginterferon alpha and the causes of suspension, as well as the required support treatment. Retrospective, descriptive study. 53 Patients were included, the treatment was interrupted in 13 cases, the majority due to a lack of virological response (n = 9). Of these 9 patients, three were treated with peginterferon alpha-2a and six with 2 b. 90% Of patients presented adverse reactions, 6% required dose adjustment and 4% needed suspension of the treatment. Despite being a treatment with high adverse reactions, the major cause of abandonment of the treatment is the lack of response. The pharmacist has an important role in the adherence and management of adverse reactions to help achieve the goal of treatment. Source

Marmol Cazas E.E.,Hospital Universitario Of Girona Dr Josep Trueta | Martinez Somolinos S.,Hospital Universitario Of Girona Dr Josep Trueta | Baldo Padro X.,Hospital Universitario Of Girona Dr Josep Trueta | Rubio Garay M.M.,Hospital Universitario Of Girona Dr Josep Trueta | And 2 more authors.
Cirugia Espanola

Introduction: A primary spontaneous pneumothorax (PSP) is due to the presence of air in the pleural space and is of unknown cause or aetiology. The main characteristic of this condition is its high tendency to re-occur. This study has two objectives: 1) to determine the efficacy of lung resection surgery using a videothorascope and talc pleurodesis, 2) to analyse the complications originating from the use of talc. Material and methods: A review was carried out on a series of 130 PSP cases treated using videothorascopy, with or without parenchymal resection, and pleurodesis with 3g of asbestos-free talc (STERITAL ®). Epidemiological data were collected, including the diagnostic method, surgical indication, mortality, general morbidity, and the specific morbidity due to talc pleurodesis, the number of recurrences, and their treatment. Results: The patients had a mean age of 26.4 years, 84.3% were male, and 69% smoked. The surgical indication of the PSP was recurrence in 74.4% of cases. There was morbidity in 7% (9) cases, with the most frequent complication being an air leak. No specific complication, such as empyema, pachypleuritis or adult respiratory distress syndrome (ARDS, on the use of talc was recorded. The mean follow-up was 10.1 months, during which there was recurrence in 4 (3%) cases. Conclusions: PSP treatment by videothorascopic talc pleurodesis is highly effective, superior to other techniques use to produce pleurodesis, has a low general morbidity, no mortality, and no specific complications due to the talc. © 2010 AEC. Source

Martinez Somolinos S.,Hospital Universitario Of Girona Dr Josep Trueta | Marmol Cazas E.E.,Hospital Universitario Of Girona Dr Josep Trueta | Sebastian Quetglas F.,Hospital Universitario Of Girona Dr Josep Trueta | Rubio Garay M.M.,Hospital Universitario Of Girona Dr Josep Trueta | And 2 more authors.
Cirugia Espanola

Introduction: Persistent air leaks (PAL) is the most frequent post-operative complication in Thoracic Surgery, leading to a longer hospital stay and an increase in patient morbidity. We present a prospective study conducted in the Dr. Josep Trueta University Hospital in Gerona, involving a portable chest drainage system (PCDS) connected to a pleural drainage which allowed air leaks to be treated ambulatorily. Our aim is to demonstrate that by using this system hospital stay is reduced without increasing post-operative morbidity, and improves the quality of life of the patient. Material and methods: The Thoracic Surgery Department of Gerona Hospital collected the data on 33 patients with PAL in the post-surgical period and who were treated ambulatorily with a PCDS. Post-operative complications were recorded, along with the mean days of ambulatory treatment with the PCDS and the hospital days saved. Results: The mean hospital stay of the 33 patients was 7.03 days. The mean number of days that the 33 patients were treated ambulatorily with the PCDS was 9.33 days. It was calculated that there was a saving of 308 hospital days. The ambulatory treatment of PAL did not increase post-operative morbidity. Conclusions: The clinical results and the management of the PCDS support the treatment of this problem in patients who do not have any other causes to remain in hospital. The study shows a saving in a considerable number of hospital days stay, with no increase in patient morbidity. All the patients preferred this system to hospital admission. © 2010 AEC. Source

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