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Wiesbaden, Germany

Pohl J.,Dr. Horst Schmidt Klinik
Video Journal and Encyclopedia of GI Endoscopy | Year: 2013

Intussusception of the appendix is a rare condition that can occasionally be observed at routine colonoscopy. Different clinical presentations have been described for appendiceal intussusception. Some mimic acute appendicitis, some present with typical symptoms of intussusception, and others are totally asymptomatic. Because it can be mistaken for a neoplastic lesion, awareness of such lesions in differential diagnosis is important. Lack of proper diagnosis will lead to complications after endoscopic removal of such polyps. Here we demonstrate a patient with asymptomatic intussusception of the appendix. This article is part of an expert video encyclopedia. © 2013 Elsevier GmbH.

Ambrose C.S.,Med Immune Ltd. | Wu X.,Med Immune Ltd. | Knuf M.,Dr. Horst Schmidt Klinik | Knuf M.,University Mainz | Wutzler P.,Friedrich - Schiller University of Jena
Vaccine | Year: 2012

Background: Nine randomized controlled clinical trials, including approximately 26,000 children aged 6 months to 17 years, have evaluated the efficacy of live attenuated influenza vaccine (LAIV) against culture-confirmed influenza illness compared with placebo or trivalent inactivated influenza vaccine (TIV). The objective of the current analysis was to integrate available LAIV efficacy data in children aged 2-17 years, the group for whom LAIV is approved for use. Methods: A meta-analysis was conducted using all available randomized controlled trials and a fixed-effects model. Cases caused by drifted influenza B were analyzed as originally classified and with all antigenic variants classified as dissimilar. Results: Five placebo-controlled trials (4 were 2-season trials) and 3 single-season TIV-controlled trials were analyzed. Compared with placebo, year 1 efficacy of 2 doses of LAIV was 83% (95% CI: 78, 87) against antigenically similar strains; efficacy was 87% (95% CI: 78, 93), 86% (95% CI: 79, 91), and 76% (95% CI: 63, 84) for A/H1N1, A/H3N2, and B, respectively. Classifying B variants as dissimilar, efficacy against all similar strains was 87% (95% CI: 83, 91) and 93% (95% CI: 83, 97) against similar B strains. Year 2 efficacy was 87% (95% CI: 82, 91) against similar strains. Compared with TIV, LAIV recipients experienced 44% (95% CI: 28, 56) and 48% (95% CI: 38, 57) fewer cases of influenza illness caused by similar strains and all strains, respectively. LAIV efficacy estimates for children from Europe, the United States, and Middle East were robust and were similar to or higher than those for the overall population. Conclusions: In children aged 2-17 years, LAIV demonstrated high efficacy after 2 doses in year 1 and revaccination in year 2, and greater efficacy compared with TIV. This meta-analysis provides precise estimates of LAIV efficacy among the approved pediatric age group. © 2011 Elsevier Ltd.

Eberlein M.,University of Iowa | Diehl E.,University of Iowa | Bolukbas S.,Dr. Horst Schmidt Klinik | Merlo C.A.,Johns Hopkins University | Reed R.M.,University of Maryland Baltimore County
Journal of Heart and Lung Transplantation | Year: 2013

Background Idiopathic pulmonary arterial hypertension (IPAH) is associated with high short-term mortality after bilateral lung transplantation (BLT). Previous studies have suggested that oversized allografts are associated with improved outcomes and that this association was strongest within the first year after transplant. We hypothesized that oversizing the allograft is associated with improved survival after BLT for IPAH. Methods All adults in the United Network of Organ Sharing lung transplant registry who underwent first-time BLT for IPAH between October 1989 and April 2010 were studied. Lung size mismatch was assessed by calculating the predicted total lung capacity (pTLC) ratio of the donor to the recipient. The cohort was divided evenly into "undersized" (pTLC ratio less than the median pTLC ratio) and "oversized" (pTLC ratio exceeding the median pTLC ratio). Risk of death after BLT was analyzed using Kaplan-Meier survival and Cox proportional hazards models. Results The mean pTLC ratio was 0.93 ± 0.10 in the 302 undersized patients compared with 1.24 ± 0.14 in the 302 oversized patients. Cohorts had comparable baseline characteristics. Median survival was 831 days longer in the oversized cohort (2,166 vs 1,335 days, p = 0.006). In a multivariate model controlling for sex mismatch, recipient factors, acuity, donor factors, and transplant factors, oversizing was associated with decreased hazard for death at 5 years (hazard ratio, 0.73; 95% CI 0.56-0.96, p = 0.02). Conclusion Oversizing the allograft is associated with improved survival after BLT for IPAH. In the setting of donor organ shortages and waiting list mortality, it is not practical to intentionally oversize the allograft. However, the pTLC ratio could provide further refinement in the peri-transplant risk assessment. © 2013 International Society for Heart and Lung Transplantation.

Pohl J.,Dr. Horst Schmidt Klinik
Video Journal and Encyclopedia of GI Endoscopy | Year: 2013

Ninety percent of patients with intraductal biliary stones are successfully treated with sphincterotomy and subsequent stone extraction. However, technical difficulty increases with stone size and giant stones require fragmentation to facilitate endoscopic removal. For stones too large to be engaged in a basket for mechanical lithotripsy, laser and electrohydraulic lithotripsy have been proposed for stone fragmentation. Application of electrohydraulic lithotripsy (EHL) is best achieved under direct visualization during cholangioscopy, because shock waves can also injure normal tissue. We present the case of a patient who underwent direct cholangioscopy for EHL of a giant stone that could not be retrieved by endoscopic retrograde cholangiopancreatography (ERCP). This article is part of an expert video encyclopedia. © 2013 Elsevier GmbH.

Bolukbas S.,Dr. Horst Schmidt Klinik | Eberlein M.,University of Iowa | Schirren J.,Dr. Horst Schmidt Klinik
Journal of Thoracic Oncology | Year: 2012

Introduction: Malignant pleural mesothelioma (MPM) can reduce lung function by entrapping lung parenchyma via a rind of tumor with or without concurrent effusion. Radical pleurectomy (RP) allows expansion of the trapped lung. The purpose of this study was to investigate changes in pulmonary function and lung perfusion in patients undergoing RP. Methods: In a prospective, nonrandomized study, all patients with histologically proven MPM were evaluated from January to December 2010 for trimodality therapy including RP as surgical procedure. Pulmonary-function tests and perfusion scans were obtained before and 2 months after RP. Primary end points were pulmonary function (forced vital capacity [FVC], forced expiratory volume in 1 second [FEV1]) and ipsilateral lung perfusion. Results: Sixteen out of 25 consecutive patients (age 68.8±8.9 years) were enrolled in the study. Macroscopic complete resection could be achieved in 13 patients (81.3%). Diaphragm resection was necessary in 5 patients. Significant postsurgical improvement of pulmonary function at 2 months was observed for FVC and FEV1 (both absolute and percentage of predicted values) and ipsilateral perfusion (p < 0.001). Avoidance of diaphragm resection was associated with greater increase in FVC (+34.6±17.0% versus +13.5±5.4%; p = 0.002) and FEV1 (+29.2±18.1% versus +12.1±6.4%; p = 0.015), respectively. Conclusions: Lung-sparing RP leads to significant improvement of pulmonary function and perfusion after a recovery time of 2 months. Functional results are better after preservation of the diaphragm. Preservation of physiological reserve via lung-sparing RP might allow patients with MPM to be eligible for further therapeutic options in the long term. © 2012 by the International Association for the Study of Lung Cancer.

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