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Comez G.,Sehitkamil State Hospital | Goktepe M.F.,Dr. Ersin Arslan State Hospital | Oztuzcu S.,University of Gaziantep | Sevinc A.,University of Gaziantep | Camci C.,University of Gaziantep
Journal of Cancer Research and Therapeutics

Diffuse large lymphomas of B-cell origin (DLBCL) comprise approximately one-third of all non-Hodgkin lymphomas (NHLs) and extranodal involvement is detected in 50% of these cases at initial diagnosis. Primary malignant lymphoma of the adrenal gland is extremely rare. Here we report a 64-year-old male patient with nasopharyngeal lymphoma who had been in remission for 2 years. An adrenal mass was detected on a control abdominal computed tomography (CT) at one of his follow-up visits. The biopsy showed DLBCL. Since the tumor was solitary without any other nodal involvement, a new/de novo primary tumor was considered. Metachronous NHLs develop between 3 months and 15 years after a primary NHLs and VDJ (variable, diversity, joining) rearrangement gene analysis of the tumor tissue is recommended to discriminate recurrence from a metachronous NHLs. VDJ rearrangement gene analysis was consistent with the recurrence of the original neoplasm. Source

Balkan F.,Aksaray State Hospital | Usluogullar A.,Dr. Ersin Arslan State Hospital | Ucler R.,Yuzuncu Yll University
Turkish Journal of Endocrinology and Metabolism

Purpose: Our objective in this study was to investigate the prevalence of metabolic syndrome in two different group of patients who had a thyroid-stimulating hormone (TSH) level within normal limits. Material and Method: Three hundred and ffty patients, who presented to Aksaray Public Hospital, Endocrinology and Metabolism Diseases Outpatient clinic and who had no thyroid disease, were included in the study. The patients were divided into two groups according to TSH levels. Group 1 had a TSH level of <2.5 mIU/L and group 2 had a TSH level of >2.5 mIU/L. The prevalence of metabolic syndrome, insulin resistance and lipid parameters were investigated in both groups. Results: A total of 350 patients were included in the study. Group 1 included 229 (65.5%) patients and group 2 included 121 (34.5%) patients. The prevalence of metabolic syndrome was found to be 112/229 (48%) in group 1 and 55/121 (45%) in group 2. There was no statistically signifcant difference between the two groups (p>0.05). FT3 level was found to be positively correlated with hip circumference (r=0.10, p=0.04), weight (r=0.12; p=0.016) and waist circumference (r=0.13; p=0.014). FT4 level was found to be positively correlated with height (r=0.12, p=0.02). Discussion: TSH level was not found to be correlated with the prevalence of metabolic syndrome (p>0.05). The prevalence of metabolic syndrome was found to be similar in both groups. © 2015 Galenos Yayincilik, All rights reserved. Source

Ahlatci A.,University of Gaziantep | Kuzhan A.,University of Gaziantep | Taysi S.,University of Gaziantep | Demirtas O.C.,University of Gaziantep | And 6 more authors.

To investigate Nigella sativa oil (NSO) and Thymoquinone (TQ) for their antioxidant effects on the brain tissue of rats exposed to ionizing radiation. Fifty-four male albino Wistar rats, divided into six groups, were designed as group I (normal control group) did not receive NSO, TQ or irradiation; group II (control group of TQ) received dimethyl sulfoxide and sham irradiation; group III (control group of NSO) received saline and sham irradiation; group IV (irradiation plus NSO group) received both 5 Gray of gamma irradiation to total cranium and NSO; group V (irradiation plus TQ group) received both irradiation and TQ; group VI (irradiation alone group) received irradiation plus saline. Alterations in nitric oxide (NO) and peroxynitrite (ONOO-) levels, and nitric oxide synthase (NOS) enzyme activity were measured by biochemical methods in homogenized brain tissue of rats. Levels of NO and ONOO-, and enzyme activity of NOS in brain tissue of the rats treated with NSO or TQ were found to be lower than in received IR alone (p < 0.002) Nigella sativa oil (NSO) and its active component, TQ, clearly protect brain tissue from radiation-induced nitrosative stress. © 2013 Elsevier GmbH. Source

Gungor O.,Kahramanmaras Sutcu Imam University | Ozkaya A.K.,Cukurova University | Gungor G.,Necip Fazl City Hospital | Karaer K.,Dr. Ersin Arslan State Hospital | And 2 more authors.
Pediatrics International

Succinate-CoA ligase, ADP-forming, beta subunit (SUCLA2)-related mitochondrial DNA depletion syndrome is caused by mutations affecting the ADP-using isoform of the beta subunit in succinyl-CoA synthase, which is involved in the Krebs cycle. The SUCLA2 protein is found mostly in heart, skeletal muscle, and brain tissues. SUCLA2 mutations result in a mitochondrial disorder that manifests as deafness, lesions in the basal ganglia, and encephalomyopathy accompanied by dystonia. Such mutations are generally associated with mildly increased plasma methylmalonic acid, increased plasma lactate, elevated plasma carnitine esters, and the presence of methylmalonic acid in urine. In this case report, we describe a new mutation in a patient with a succinyl-CoA synthase deficiency caused by an SUCLA2 defect. © 2016 Japan Pediatric Society Source

Kaplan M.,Medical Park Gaziantep Hospital | Iyikosker H.T.,Dr. Ersin Arslan State Hospital
World Journal of Surgical Oncology

Background: Primary visceral malignant fibrous histiocytoma (MFH) is a rare disease, and few cases have been reported in the English literature. However, retained foreign bodies in the abdomen after surgical procedures are important causes of intra-abdominal infections. For legal and ethical reasons, there are few publications in the literature. In this article, we describe for the first time a case of malign abdominal fibrous histiocytoma associated with a surgical sponge forgotten in the abdominal cavity a long time ago.Case presentation: A 64-year-old male presented to our surgical department with cachexia, abdominal pain, distention and pyrexia of unknown origin. He had a medical history of abdominal surgery for peptic ulcer perforation 32 years ago. Clinical examination revealed fever with a distended and painful abdominal wall. Radiological imaging of the abdomen showed multiple heterogeneous masses in one large cystic cavityalmost completely filling the abdomen. The patient underwent a laparotomy, and interestingly, opening the cyst revealed retained surgical gauze (RSG). The origin of the tumor was the visceral peritoneum, and it was excised totally.Conclusions: Primary intra-abdominal MFH can present as a complication of long-lasting RSG. Therefore, clinicians must remember this while establishing the differential diagnosis for patients with a history of previous abdominal surgery and presenting with symptoms associated with both the tumor and systemic inflammatory response. © 2012 Kaplan and Iyikosker; licensee BioMed Central Ltd. Source

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