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Sharma S.K.,Saraswathi Institute of Medical | Tilak M.A.,Dr Dy Patil Medical College
Indian Journal of Public Health Research and Development

Objective: The aim of the present study is to estimate the serum AST and ALT in alcoholic, nonalcoholic liver disease patients and in healthy controls for the assessment of Deritis to evaluate its clinical significance in differentiation of alcoholic liver disease from non-alcoholic liver disease. Method: 100 cases of each alcoholic and non-alcoholic hepatitis between the ages of 40-65 years were included in the study and 100 ages matched healthy individuals served as control. Serum AST and ALT levels were determined by enzymatic methods by kits obtained from CPC diagnostics. Results: It is found that AST and ALT levels are higher in both alcoholic as well as non-alcoholic hepatitis as compared to controls but it is statistically significant in case of alcoholic hepatitis. Similarly AST/ALT ratio is higher in both alcoholic and nonalcoholic hepatitis as compared to controls but it is statistically significant in case of alcoholic hepatitis only when compared to both non-alcoholic hepatitis and control. Conclusion: The findings of the present study suggest that in alcoholic hepatitis release of transaminases into the circulation in such a way that amount of AST released is more than that of ALT so that ratio of AST to ALT is significantly higher in case of ALD. Hence, the Deritis ratio can be considered as a reliable marker of ALD. Thus estimation of the Deritis ratio is essential to understand the nature of liver disease. © 2014, Indian Journal of Public Health Research and Development. All rights reserved. Source

Jayalaksmi T.K.,Dr Dy Patil Medical College
The Journal of the Association of Physicians of India

49 year old female, a known case of thalassemia minor with hypothyroidism on treatment, presented with left sided massive pleural effusion. Pleural tapping revealed exudative effusion and she was started on four drug AKT. She had recurrent pleural effusions and required repeated aspirations. Thoracoscopic pleural biopsy revealed non caseating granulomas. She continued to deteriorate after 8 months of AKT and was readmitted with severe vomiting, ataxia, diplopia, weakness and weight loss. Investigations revealed miliary pattern on CXR and multiple granulomatous lesions in the brain on MRI. She responded to treatment with high dose corticosteroids. We are presenting this case to highlight sarcoidosis as one of the causes of large pleural effusion. Source

Patil S.R.,Dr Dy Patil Medical College | Bharadwaj J.,Ss Institute Of Medical Science And Research Center
Journal of Postgraduate Medicine

Background: Calculation of daily calorie needs is extremely essential in several aspects of public health nutrition. Aims: To check the applicability of the existing equations for the prediction of basal metabolic rate (BMR) for Indian adolescent population and to develop an appropriate equation for the estimation of BMR for Indian adolescent population. Materials and Methods: BMR was assessed in 152 healthy, adolescent student aged between 18 and 20 years. BMR is calculated from the measured skinfold parameters. Body density was determined by the equation suggested by Durnin and Wormley using the skinfold parameters (triceps, subscapula, biceps, and SIM). Siri′s equation is employed for calculating the percentage of body fat from the body density. Eventually, the BMR is calculated using Cunningham′s equation. The actual BMR′s were compared with values obtained from published prediction equations that used solely, or in various combinations, measures of height, weight, and age. Results: The equations suggested in the literature (Henry, Schofield, and Cole) are not able to predict the BMRs for Indian adolescent population. Hence, a new equation involving weight of an individual is suggested for Indian adolescent population. Conclusions: There is a need for generation of appropriate BMR prediction equations for Indian population for various age groups. Source

Patil M.B.,Dr Dy Patil Medical College
Indian Pediatrics

Left ventricular noncompaction (LVNC) is a rare form of cardiomyopathy of emerging importance. We report a case of a 3- months- old boy who presented with congestive heart failure due to LVNC. Source

Jethani S.,Dr Dy Patil Medical College | Semwal J.,University | Kakkar R.,University | Rawat J.,University
Indian Journal of Community Health

Introduction: Tuberculosis is a disease of poverty affecting mostly young adults in their most productive years. WHO has suggested that the expected effect of improved diagnostic and treatment services may be negated by an increase in the prevalence of risk factors for the progression of latent TB to active disease in segments of the population. The risk factors broadly described may be biomedical, environmental or socioeconomic. The impact of these other determinants on TB epidemiology in lndia has yet to be fully understood Methodology: Study was undertaken on all patients in the age group of 18 years and above with history of cough for more than 2 weeks attending DOTS Microscopy centre of HIMS with or without other symptoms suggestive of tuberculosis attending DOTS Microscopy centre for a period of six months i.e. from 1st July to 31st December 2010 were included in study group. Total patients attended the centre were 538. Results: Majority of participants were farmers 159(43.9%) belonging to lower socio-economic status. Out of 362 study subjects maximum i.e. 162 (44.8%) had past history of pulmonary tuberculosis and only 18 (5.0%) subjects had family history of tuberculosis. While majority (45%) had past history of tuberculosis of which 37.1% had sputum positivity. Smoking was found to be most common type of addiction among 207 (57.2%) followed by alcohol i.e. 129 (35.6%). Conclusion: Epidemiological factors like literacy status, socioeconomic status, previous history of tuberculosis, smoking & BMI play important role in causation of Tuberculosis. Source

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