Srinath S.,Dr Dy Patil Medical College
Interdisciplinary Toxicology | Year: 2012
The protective effects of aqueous extracts of the fruit rind of Garcinia indica (GIE) on ethanol-induced hepatotoxicity and the probable mechanisms involved in this protection were investigated in rats. Liver damage was induced in rats by administering ethanol (5 g/kg, 20% w/v p.o.) once daily for 21 days. GIE at 400 mg/kg and 800 mg/kg and the reference drug silymarin (200 mg/kg) were administered orally for 28 days to ethanol treated rats, this treatment beginning 7 days prior to the commencement of ethanol administration. Levels of marker enzymes (aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP)), triglyceride (sTG), albumin (Alb) and total protein (TP) were evaluated in serum. Antioxidant parameters (reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR)), hepatic triglycerides (hTG) and the lipid peroxidation marker malondialdehyde (MDA) were determined in liver. GIE and silymarin elicited significant hepatoprotective activity by attenuating the ethanol-elevated levels of AST, ALT, ALP, sTG, hTG and MDA and restored the ethanol-depleted levels of GSH, SOD, CAT, GPx, GR, Alb and TP. GIE 800 mg/kg demonstrated greater hepatoprotection than GIE 400 mg/kg. The present findings indicate that hepatoprotective effects of GIE in ethanol-induced oxidative damage may be due to an augmentation of the endogenous antioxidants and inhibition of lipid peroxidation in liver. © 2012 SETOX & IEPT, SASc.
Ambadasu B.,s Shri Patil Medical College Hospital and Research Center |
Dange S.V.,Dr DY Patil Medical College |
Wali R.S.,s Shri Patil Medical College Hospital and Research Center |
Worlikar P.S.,Dr DY Patil Medical College
International Journal of Pharma and Bio Sciences | Year: 2013
Objectives: To study the Effect of Caralluma Fimbriata extract (CFE) on appetite & lipid profile in rats fed with hypercalorie/cafeteria diet. Methods: Wistar rats weighing 180-240g were randomly divided into three groups (n=6 each); i) Control, ii) Cafeteria Diet (CD), and iii) Cafeteria diet + CFE. CFE was administered at 100 mg/kg/day p.o. for 50 days. Food intake, animal's bodyweight, blood glucose, serum lipid levels were measured -at baseline, every 10 days and at term. Liver Function Tests & Renal Function Tests were measured at baseline and at term. Results: Treatment with CFE at a dose of 100 mg/kg/day significantly (P <0.05) reduced the increase in body weight and lipid profile levels as compared to the CD control group. Conclusions: Caralluma fimbriata extract prevented gain in body and alterations in lipid profile caused by Cafeteria Diet. Hence, this agent might be useful in treatment of obesity.
Patil S.R.,Dr Dy Patil Medical College |
Bharadwaj J.,Ss Institute Of Medical Science And Research Center
Journal of Postgraduate Medicine | Year: 2013
Background: Calculation of daily calorie needs is extremely essential in several aspects of public health nutrition. Aims: To check the applicability of the existing equations for the prediction of basal metabolic rate (BMR) for Indian adolescent population and to develop an appropriate equation for the estimation of BMR for Indian adolescent population. Materials and Methods: BMR was assessed in 152 healthy, adolescent student aged between 18 and 20 years. BMR is calculated from the measured skinfold parameters. Body density was determined by the equation suggested by Durnin and Wormley using the skinfold parameters (triceps, subscapula, biceps, and SIM). Siri′s equation is employed for calculating the percentage of body fat from the body density. Eventually, the BMR is calculated using Cunningham′s equation. The actual BMR′s were compared with values obtained from published prediction equations that used solely, or in various combinations, measures of height, weight, and age. Results: The equations suggested in the literature (Henry, Schofield, and Cole) are not able to predict the BMRs for Indian adolescent population. Hence, a new equation involving weight of an individual is suggested for Indian adolescent population. Conclusions: There is a need for generation of appropriate BMR prediction equations for Indian population for various age groups.
Bankar S.M.,Dr Dy Patil Medical College |
Powar R.M.,Government Medical College |
Patil S.A.,Government Medical College |
Kalthur S.G.,Manipal University India
Annals of Tropical Medicine and Public Health | Year: 2012
Background: Candida is the most common agent causing leucorrhea affecting the women of all strata. It is becoming difficult to completely eradicate the infection mainly due to recurrence caused by non-albican species of Candida. Most of the non-albican species of Candida are resistant to commonly used antifungal agent-azole. Therefore, studying the prevalence of Candida species in vaginal secretion is of great significance. Objective: To study the prevalence of different species of Candida and the efficiency of different Candida detection methods in women from low socio-economic setup of Miraj and Sangli, Maharashtra, India. Materials and Methods: The study was conducted on 150 patients with specific complaints of leucorrhea. In the control group, 50 asymptomatic women were included for comparison. Results: In 33% of the women the leucorrhea was due to Candida infection with highest incidence in women of sexually active age (20-40 years). Sabouraud′s culture was the most efficient method (100% efficiency) to detect the Candida compared to wet mount, KOH and gram stain method. Candida albicans was the most common strain identified and Candida krusei was the least common one. Conclusion: Candida infection is the commonest reason for leucorrhea and non-albican candida species significantly contribute to candidiasis in women of Miraj and Sangli.
Vaishnav A.,Dr Dy Patil Medical College |
Lokhandwala Y.,Holy Family Hospital
Indian Heart Journal | Year: 2014
Atrial fibrillation is the most common sustained cardiac arrhythmia which is often troublesome to manage. Currently, rhythm and rate control medications are the mainstays of therapy. In 2 amiodarone-refractory highly symptomatic patients, an innovative approach using ranolazine, which selectively acts on Na+ channels and delays atrial depolarization, was tried successfully. Copyright © 2013, Cardiological Society of India. All rights reserved.
Jayalaksmi T.K.,Dr Dy Patil Medical College
The Journal of the Association of Physicians of India | Year: 2010
49 year old female, a known case of thalassemia minor with hypothyroidism on treatment, presented with left sided massive pleural effusion. Pleural tapping revealed exudative effusion and she was started on four drug AKT. She had recurrent pleural effusions and required repeated aspirations. Thoracoscopic pleural biopsy revealed non caseating granulomas. She continued to deteriorate after 8 months of AKT and was readmitted with severe vomiting, ataxia, diplopia, weakness and weight loss. Investigations revealed miliary pattern on CXR and multiple granulomatous lesions in the brain on MRI. She responded to treatment with high dose corticosteroids. We are presenting this case to highlight sarcoidosis as one of the causes of large pleural effusion.
Jethani S.,Dr Dy Patil Medical College |
Semwal J.,HlHT University |
Kakkar R.,HlHT University |
Rawat J.,HlHT University
Indian Journal of Community Health | Year: 2012
Introduction: Tuberculosis is a disease of poverty affecting mostly young adults in their most productive years. WHO has suggested that the expected effect of improved diagnostic and treatment services may be negated by an increase in the prevalence of risk factors for the progression of latent TB to active disease in segments of the population. The risk factors broadly described may be biomedical, environmental or socioeconomic. The impact of these other determinants on TB epidemiology in lndia has yet to be fully understood Methodology: Study was undertaken on all patients in the age group of 18 years and above with history of cough for more than 2 weeks attending DOTS Microscopy centre of HIMS with or without other symptoms suggestive of tuberculosis attending DOTS Microscopy centre for a period of six months i.e. from 1st July to 31st December 2010 were included in study group. Total patients attended the centre were 538. Results: Majority of participants were farmers 159(43.9%) belonging to lower socio-economic status. Out of 362 study subjects maximum i.e. 162 (44.8%) had past history of pulmonary tuberculosis and only 18 (5.0%) subjects had family history of tuberculosis. While majority (45%) had past history of tuberculosis of which 37.1% had sputum positivity. Smoking was found to be most common type of addiction among 207 (57.2%) followed by alcohol i.e. 129 (35.6%). Conclusion: Epidemiological factors like literacy status, socioeconomic status, previous history of tuberculosis, smoking & BMI play important role in causation of Tuberculosis.
Patil M.B.,Dr DY Patil Medical College
Indian Pediatrics | Year: 2012
Left ventricular noncompaction (LVNC) is a rare form of cardiomyopathy of emerging importance. We report a case of a 3- months- old boy who presented with congestive heart failure due to LVNC.
Dunghav V.A.,Dr Dy Patil Medical College
World Journal of Laparoscopic Surgery | Year: 2015
Uterine leiomyomas are one of the most common benign smooth muscle tumors in women, with a prevalence of 20 to 40% in women over the age of 35 years. Although many women are asymptomatic, problems, such as bleeding, pelvic pain, and infertility may necessitate treatment. Laparoscopic myomectomy is one of the treatment options for myomas. The major concern of myomectomy either by open method or by laparoscopy is the bleeding encountered during the procedure. Most studies have aimed at ways of reducing blood loss during myomectomy. There are various ways in which bleeding during laparoscopic myomectomy can be reduced, the most reliable of which is ligation of the uterine vessels bilaterally. In this review, we propose to discuss the benefits and possible disadvantages of ligating the uterine arteries bilaterally before performing laparoscopic myomectomy. © 2015, Jaypee Brothers Medical Publishers (P) Ltd. All rights reserved.
PubMed | Dr Dy Patil Medical College
Type: Journal Article | Journal: Indian journal of urology : IJU : journal of the Urological Society of India | Year: 2016
Uroflowmetry is the objective method of measuring rate of urine flow. Nomograms are required to observe the change in flow rates at different voided volumes (VVs) and the use of which overcomes the limitation of referencing flow rates to any single VV. The purpose of the present study was to construct the Indian uroflow nomogram for adult healthy males between 15-40 years of age.A total of 1000 healthy males between 15 and 40 years of age were included in the study. Exclusion criteria were any urinary symptoms or urological intervention. Parameters analyzed statistically were age, peak flow rate (QThe mean age was 27.26 6.71 years. The mean QQ