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Patil Pallavi M.,Tamil University | Patil Pallavi M.,P.A. College | Wankhede Sagar B.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | Chaudhari Praveen D.,P.A. College
International Journal of Pharma and Bio Sciences | Year: 2014

A novel and quick high-performance thin-layer chromatographic method -densitometric method was developed and validated for quantitative determination of Valacyclovir Hydrochloride. Chromatographic separation of the drugs was performed on precoated silica Tab 60 F254 Merck plates using Toluene: Methanol: Diethylamine (8:1:1 v/v/v).as a mobile phase. A TLC scanner set at 254 nm was used. Valacyclovir Hydrochloride and degradant were satisfactorily resolved with Rf values of 0.28 ± 0.05, 0.65 ±0.05. The method had an accuracy of 99.85% of Valacyclovir Hydrochloride was validated according to ICH guidelines. The percentage recovery ranges from 99-101%. Force degradation of drugs in hydrolysis, oxidation photolysis and thermal stress as per ICH guideline. The drug showed instability in oxide and Heat and Oxide while it remained stable in neutral conditions. The proposed HPTLC method was utilized to investigate of alkaline degradation of VAL. Source


Muley M.M.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | Thakare V.N.,Sinhgad Institute of Pharmaceutical science | Patil R.R.,Sinhgad Institute of Pharmaceutical science | Bafna P.A.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | Naik S.R.,Sinhgad Institute of Pharmaceutical science
Life Sciences | Year: 2013

Aims The neuroprotective activities of silymarin, piracetam and protocatechuic acid ethyl ester (PCA) on cerebral global ischemic/reperfusion were evaluated in a rat model. Main methods A midline ventral incision was made in the throat region. The right and left common carotid arteries were located and a bilateral common carotid artery occlusion (BCCAO) was performed for 30 min using atraumatic clamps followed by a 24 h period of reperfusion. Neurological/behavioral functions (cognitive and motor), endogenous defense systems (lipid peroxidation, glutathione, catalase, and superoxide dismutase), reduced water content and infarct size and histopathological alterations were then studied. Key findings Silymarin and PCA treatments significantly improved cognitive, motor and endogenous defense functions, histopathological alterations, and, reduced both water content and infarct size compared to the vehicle-treated ischemic control group. Piracetam treatment improved neurological and histopathological alterations, reduced water content and infarct size, but failed to restore/prevent the impaired endogenous defense functions significantly. Significance Silymarin showed better neuroprotection than piracetam and PCA in experimentally induced global ischemic/reperfusion and was able to facilitate mnemonic performance. © 2013 Elsevier Inc. Source


Kshirsagar A.D.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | Aggarwal A.S.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | Harle U.N.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | Deshpande A.D.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research
Diabetes and Metabolic Syndrome: Clinical Research and Reviews | Year: 2011

The dipeptidyl peptidase IV (DPP IV) enzyme is a novel target for the treatment of type 2 diabetes. Several DPP IV inhibitors are in the clinical development, since they are safe and tolerable with no increased risk of adverse events compared to placebo and have a low risk of hypoglycemia. They are flourishing as monotherapy and also in combination with commonly prescribed antidiabetic agents and are appropriate for once-daily oral dosing. However, further studies are needed to validate both long-term β-cell preservation and the role of these agents in the management of diabetes. The present review gives an inside out of the DPP IV inhibitors for its success, failure and future prospects in the treatment of diabetes and associated complication. © 2012 Diabetes India. Published by Elsevier Ltd. All rights reserved. Source


Zope V.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | Takawale A.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | Navghare V.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | Tanwar M.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | Deshpande A.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research
Pharmaceutical Biology | Year: 2010

Context: The whole plant of Sphaeranthus indicus Linn. (Asteraceae) is traditionally used in the treatment of diabetes mellitus. Objective: The present study investigated the effect of the methanol extract of Sphaeranthus indicus whole plant in dexamethasone-induced insulin resistance in mice. Materials and methods: The mice were treated with dexamethasone for 22 days and effects on plasma glucose level, serum triglyceride level, glucose uptake, levels of hepatic enzymes like glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), lipid peroxidase (LPO), and body weight was observed. Results: The Sphaeranthus indicus extract (SI) showed significant decrease in plasma glucose and serum triglyceride levels (p <0.01) at doses, of 400 and 800mg/kg, p.o., and stimulated insulin assisted and non-insulin assisted glucose uptake in skeletal muscle. The levels of antioxidant enzymes GSH, SOD, and CAT were significantly increased (p <0.01) and there was a significant decrease in level of LPO (p <0.01). SI significantly restored (p <0.01) dexamethasone induced body weight loss. Discussion and conclusion: Sphaeranthus indicus may prove to be effective in the treatment of type II diabetes mellitus owing to its ability to decrease insulin resistance. © 2010 Informa Healthcare USA, Inc. Source


Thomas A.B.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | Sharma P.A.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | Tupe P.N.,Institute of Chemical Technology | Badhe R.V.,Padm Dr Dy Patil Institute Of Pharmaceutical Science And Research | And 5 more authors.
Green Chemistry Letters and Reviews | Year: 2011

The broad and potent activity of 4-thiazolidinones has established it as one of the biologically important scaffolds. The synthesis of N-(2-aryl-4-oxothiazolidin-3-yl)isonicotinamide by a novel method of stirring and sonication is described. The conventional method for synthesis of 4-thiazolidinones involves use of a Dean-Stark water separator for the removal of water from the reaction with long reaction times (12-w48 h), and the stirring procedure also involves the use of DCC (dicyclohexylcarbodiimide) as a dehydrating agent. We report the synthesis of 4-thiazolidinone analogs of isonicotinic acid hydrazide by novel, green route methods of sonication and stirring using molecular sieves. Results indicate that high yields and shorter reaction times can be achieved by employing novel green route methods of synthesis. © 2011 Taylor & Francis. Source

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