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Lakhanpal G.,Dr D Ypatil Medical College | Bhalerao S.,Dr D Ypatil Medical College | Sharma S.,Dr D Ypatil Medical College | Patil H.,Dr D Ypatil Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

The aim of the study was to evaluate the effect of different formulations of Aloe vera on wound healing using Burn model in rats and to compare these different formulations with Framycetin sulphate.The study was approved by the Institutional Animal Ethics Committee. 50 Sprague-Dawley rats, of either sex, weighing 150-200g, were selected randomly divided into the following groups: (n=10 each) Group I-Untreated; Group II-Aloe gel treated ; Group III-Aloe pulp treated ; Group IV-Aloe powder treated ; Group V-Framycetin cream treated. The partial thickness burn wounds were inflicted upon animals under ketamine anaesthesia, by pouring boiling water (above 100 degree C). The study formulations were applied topically daily till the complete healing of the wound. The following parameters were measured:1.)Measurement of Wound Contracture 2.) Period of re-epithelization. In burn model, Aloe pulp and Framycetin treated groups showed maximum wound contracture on day 21 as compared to Untreated groups and shorter period of re-epithelization in Aloe pulp and Framycetin treated groups as compared to Untreated groups. In household burns, Aloe pulp obtained directly from the plant which is comparable to Framycetin cream can be recommended as a faster remedy, safe and readily available alternative. Source

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