Dr P Y Patil Institute Of Pharmaceutical Science And Research

science and, India

Dr P Y Patil Institute Of Pharmaceutical Science And Research

science and, India
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Bhujbal S.S.,Dr P Y Patil Institute Of Pharmaceutical Science And Research | Nanda R.,Dr P Y Patil Institute Of Pharmaceutical Science And Research | Ganu G.P.,Dr P Y Patil Institute Of Pharmaceutical Science And Research | Jadhav S.W.,Dr P Y Patil Institute Of Pharmaceutical Science And Research | And 4 more authors.
Journal of Complementary and Integrative Medicine | Year: 2010

Plant saponins are widely distributed amongst plants and have a wide range of biological properties. Icosahydropicenic acid (IHPA), a new pentacyclic triterpenoid saponin was first time isolated from the roots of Clerodendrum Serratum (L) Moon (Verbenaceae). IHPA, at the dose of 100mg/kg, showed significant protection of mast cell degraualtion (59.62%) as compared to standard sodium cromoglycate (64.48%). The compound also revealed significant inhibitory activity on histamine-induced goat tracheal chain preparation. The study provides scientific basis for its clinical use in the treatment of asthma. © 2010 The Berkeley Electronic Press. All rights reserved.

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