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Afsar F.S.,Dr Behcet Uz Childrens Hospital
Current Opinion in Pediatrics | Year: 2010

Purpose of review: In developing countries, where the majority of people have a low income and live in resource-poor settings, skin infections are prevalent. Data from recent studies provide insight into the most common skin infections and their management. Recent findings: Several studies confirm that skin infections account for the majority of pediatric mortality and morbidity in developing countries. They are prevalent in resource-poor settings and rural areas in certain parts of the world. Also, hot, humid climates and overcrowding predispose to skin infections. Most of the skin infections are curable with effective medication. Summary: Skin infections are of particular importance in developing countries. This review focuses on the most common skin infections and summarizes the most recent knowledge on the epidemiology, morbidity, and treatment in resource-poor settings. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source


Ulug M.,Ozel Umit Hospital | Yaman Y.,Dr Behcet Uz Childrens Hospital | Yapici F.,Ozel Sante Plus Hospital | Can-Ulug N.,Ozel Umit Hospital
Turkish Journal of Pediatrics | Year: 2011

Brucellosis, whether in an endemic region or not, remains a diagnostic puzzle due to occasional misleading unusual presentations and non-specific symptoms. The aim of this study was to evaluate the clinical and laboratory findings, complications and treatment outcome of brucellosis in children in southeastern Anatolia, Turkey. This study focuses on the frequency of clinical and laboratory findings and complications in cases with brucellosis. Of 22 patients, 8 (36.3%) were female and 14 (63.7%) were male. Fever, malaise, lack of appetite, arthralgia, and night sweating were the main presenting symptoms overall. Hematologic complications (n=13, 59.1%) were most common, followed by skeletal (n=7, 31.8%) and cutaneous system (n=1, 4.5%). Brucellosis may affect any organ system and imitate a variety of clinical entities. Diagnosis of brucellosis should be considered whenever there is a febrile illness associated with rheumatological complaints. Consequently, early recognition of the infection, prolonged antibiotic treatment and careful long-term follow-up should improve the patient outcome. Source


Afsar F.S.,Dr Behcet Uz Childrens Hospital
Clinical and Experimental Dermatology | Year: 2010

Skin problems in children during the first few weeks of life can raise concern, even for experienced neonatologists and paediatric dermatologists. The skin of preterm and term newborn babies has distinct differences from juvenile and adult skin. An understanding of the nature of neonatal skin, the physiological and nonphysiological skin conditions of preterm and term neonates, and skin care are essential in paediatric practice. This article discusses the nature of the neonatal skin and its physiological phenomena. © 2009 British Association of Dermatologists. Source


Kamer E.,1834 sok. No 9 4 | Unalp H.R.,Ankent Bl. No 7 | Diniz G.,Dr Behcet Uz Childrens Hospital | Bozdag A.D.,Mithatpasa Cad. No 387 7 | Ortac R.,Dr Behcet Uz Childrens Hospital
Langenbeck's Archives of Surgery | Year: 2010

Purpose We aimed to investigate the effect of sildenafil on the healing process of abdominal wall wound in rats. Materials and methods The study was performed with adult female Wistar-Albino rats. Control group (n=50) were fed on standard laboratory diet until 12 h before surgery. Study group (n=50) were applied orally with orogastric tube 10 mg/kg once a day for 10 days of sildenafil therapy. Each rat was anesthetized, and a 4-cmlong midline laparotomy was performed. Ten animals from each group were killed at postoperative days (PODs) 4, 7, 14, 21, and 35. Breaking strength analysis was measured, and the abdominal incision wounds were examined histologically. Results Breaking strength for the midline incision, acute inflammation score on POD 14, and neovascularization on PODs 7, 14, 21, and 35 were significantly higher in the study group. Conclusions Sildenafil can be used as a supporting factor in wound healing. © Springer-Verlag 2009. Source


Yilmaz U.,Dr Behcet Uz Childrens Hospital | Celegen M.,Dr Behcet Uz Childrens Hospital | Yilmaz T.S.,Dokuz Eylul University | Gurcinar M.,Alsancak Center | Unalp A.,Dr Behcet Uz Childrens Hospital
European Journal of Paediatric Neurology | Year: 2014

Background Headaches are common in children and brain magnetic resonance imaging (MRI) studies are widely used in everyday clinical practice because of increasing demands by parents. Aim To determine headache types and to evaluate the frequency and clinical significance of brain MRI abnormalities in children with headache. Methods A total of 449 children (261 male and 188 female with a mean age of 11.16 ± 3.22 years) with headache were included into the study. The criteria defined by International Headache Society were used to classify the headache types. Results The causes of headache were migraine in 247 (55.0%), tension-type in 133 (29.6%), secondary in 48 (10.7%), and unspecified headaches in 21 (4.7%) patients. Overall, 324 (72.2%) patients underwent cerebral MRI, which revealed abnormalities in 68 (21.0%) patients. Two (0.6%) patients had cerebral MRI abnormalities relevant to headache, including tumor and hydrocephalus each 1 (0.3%). Twenty-nine (8.9%) patients had incidental cerebral MRI abnormalities including 14 (4.3%) white-matter hyperintensities, 4 (1.2%) old infarcts, 3 (0.9%) Chiari malformations, arachnoid cysts and demyelinating lesions each 2 (0.6%), and subdural hygroma, fibrous dysplasia, pineal cyst and perivascular widening, each 1 (0.3%). Remaining 36 (11.1%) patients had extra-cerebral MRI abnormalities including 34 (10.5%) sinus disease, and 2 (0.6%) adenoid vegetation. Indications for brain MRI were atypical headache pattern or presence of neurologic abnormalities in 59 (18.2%) patients and parents' concerns in 265 (81.8%) patients. The rates of abnormal MRI findings were similar between these 2 groups. Conclusions The most frequent cause of headache in children is migraine. Despite the high rate of imaging abnormalities, the yield of brain MRI is not contributory to the diagnostic and therapeutic approach. © 2013 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved. Source

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