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Ceyhan M.,Hacettepe University | Gurler N.,Istanbul University | Yaman A.,Cukurova University | Ozturk C.,Mersin University | And 14 more authors.
Clinical and Vaccine Immunology | Year: 2011

Before use of the pneumococcal conjugate vaccine PCV7 became widespread in Turkey, 202 invasive pneumococcus isolates were analyzed. The most common serotypes were 19F and 6B. In children ≤2 years of age, the potential coverage rate of PCV7 was 69.5%. The most frequent non-PCV7 serotypes were 19A, 3, 1, 6A, and 8. Copyright © 2011, American Society for Microbiology. All Rights Reserved.


Akar E.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Unalp A.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Diniz G.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Ortac R.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | And 6 more authors.
Folia Neuropathologica | Year: 2015

Introduction: Haemolytic disease of newborns due to rhesus and ABO incompatibility is encountered frequently in neonatal clinics and may lead to severe haemolysis. In this study, it is suggested that important amounts of iron released with haemolysis may have a toxic effect on the brain parenchymal tissue, and the severity of the toxic effect can be correlated with the maturation of the brain barrier systems. To demonstrate the accumulation and the neurotoxic effects of free iron (Fe) in the brain an experimental haemolysis model with various maturation phases was performed. Material and methods: The study was composed of 48 Wistar rats with the following ages: five days old (Group A), 10 days old (Group B), and 19 days old (Group C). Each group was divided into three experimental subgroups and three control groups. Experimental groups were treated with intraperitoneal 75 mg/kg/day phenyl hydrazine hydrochloride for haemolysis. Results: We demonstrated that the blood brain barrier (BBB) is permeable in five-day-old newborn rats and is mature in 10- and 19-day-old rats. Iron staining and neuronal damage were detected in group A and group B rats. No damage was detected in the brain tissue of group C animals. The presence of iron staining and neuronal damage in group B with mature BBB may suggest the existence of other incomplete barrier systems different from BBB that lead to iron accumulation in the brain. Conclusions: Blood brain barrier has a partial role in Fe transport, and the alternative barrier systems may also be involved. It could be supposed that after maturation of all barrier systems, excessive Fe penetration to the brain cannot occur. Our findings showed that the toxic amounts of iron may penetrate into the brain parenchyma of newborns despite the BBB preservation and cause neuronal damage in newborns, but the mature brain is not affected by the same magnitude blood levels.


Dincel N.,Ege University | Unalp A.,Dr Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital | Kutlu A.,Dr Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital | Ozturk A.,Dr Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital | And 2 more authors.
Indian Journal of Medical Research | Year: 2013

Background & objectives: It has been hypothesized that abnormal levels of serum nerve growth factor (NGF) may represent a serological marker for autistic children who may develop cognitive impairment, regression and finally epilepsy. The objective of this preliminary study was to measure serum NGF concentrations of autistic children and compare these levels with those of healthy children. Methods: Consecutive children who were referred to the Paediatric Neurology and Child Psychiatry Policlinics of Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Turkey between February and September 2008 were included in the study. Serum samples were analyzed for NGF levels using ChemiKine NGF Sandwich ELISA Kit. Comparisons between the study and the control groups were made using student's t test and Chi-square test. Results: Forty-nine autistic children and an equal number of healthy children (control group) were included in the study. No significant difference was found between the study and the control groups in terms of children's age, while number of boys was significantly higher (P<0.05) in the study group. Average serum NGF concentrations were 46.94 ± 51.40 and 32.94 ± 12.48 pg/ml in the study and control group, respectively. Serum NGF concentrations were significantly higher (P<0.05) in the study group compared with the control group. Interpretation & conclusions: Our preliminary findings show that enhanced serum NGF concentration may be used as a potential diagnostic tool in autism, however, further studies including a large number of patients are required to confirm the findings.


Topcu Y.,Dokuz Eylül University | Bayram E.,Dokuz Eylül University | Karaoglu P.,Dokuz Eylül University | Yis U.,Dokuz Eylül University | And 2 more authors.
Pediatric Emergency Care | Year: 2014

The most common cause of recurrent rhabdomyolysis in childhood is inherited metabolic disorders. Carnitine palmitoyl transferase II (CPT II) deficiency is a lipidosis and is a common cause of inherited recurrent myoglobinuria. The disease is inherited in autosomal recessive trait, and the clinical phenotype ranges from a severe and multisystemic infantile form to a milder muscle form, which is characterized with rhabdomyolysis and myoglobinuria. Exercise, infection, fasting, and cold are the most important triggering factors of rhabdomyolysis in CPT II deficiency. The severity of attacks is highly variable and some of these attacks may be complicated by acute renal failure. We report a case of a 13-year-old girl with recurrent rhabdomyolysis due to CPT II deficiency whose last attack was complicated by acute renal failure. © 2014 Lippincott Williams & Wilkins.


Agin H.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Ayhan Y.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Devrim I.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Gulfidan G.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | And 2 more authors.
Mycopathologia | Year: 2011

Candida ciferrii, which is known as an agent of superficial yeast infection and onychomycosis, has rarely been isolated as an agent of candidemia. Limited reports have suggested different patterns of antifungal sensitivity. We report a rare candidemia case caused by c. ciferrii in an 8-year-old child in which isolated candida species were resistant to amphotericin-B (MIC > 1 μg/ml), fluconazole, (MIC ≥ 64 μg/ml), caspofungin (MIC ≥ 32 μg/ml), and anidulafungin (MIC ≥ 32 μg/ml) but sensitive to voriconazole (MIC ≤ 0.12 μg/ml). As far as we aware, this was the first recorded C. ciferrii candidemia case in children. © 2011 Springer Science+Business Media B.V.


Agin H.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Apa H.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Unalp A.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Kayserili E.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital
Neurosciences | Year: 2010

Acute disseminated encephalomyelitis (ADEM) is an acute demyelinating infection of the CNS that is characterized by multifocal white matter involvement often following an infection and vaccination. A 16-year-old child receiving risperidone for 7 years for the treatment of attention-deficit/ hyperactivity disorder was hospitalized with complaints of double-vision during the past month and weakness on his right side, ataxia, and vomiting over the past 3 days. The child was diagnosed with ADEM after clinical, laboratory, and cranial MRI was conducted. Following an initial 3-day therapy with pulsed methylprednisolone, the child showed obvious clinical improvement. The treatment was continued with prednisolone and significant improvement was achieved. Enterovirus was detected in the results of the viral examination of the CSF. This child was found to be an interesting case having been diagnosed with ADEM associated with enteroviral infection, because of the rarity of few case reports in the literature.


Tat F.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Devrim I.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Gulfidan G.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Gunay I.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital | Dizdarer C.,Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital
Infectious Diseases in Clinical Practice | Year: 2012

Sphingomonas paucimobilis, which was previously named as Pseudomonas paucimobilis in 1977 as an etiologic agent of human infection, is a nonfermenting gram-negative bacillus found in soil and water. Limited reports of S paucimobilis infection have been documented to date. Especially, nosocomial infections are common, and generally, adults are the primary victims. It was rarely reported in childhood. In this case report, a 22-month-old immunocompetent boy who had had S paucimobilis bacteremia complicated with sepsis and associated meningitis was reported. Our patient had no history of immunosuppression or associated disease. The patient had been treated with ceftriaxone for the diagnosis of acute otitis media at a local clinic. Upon admission, the initial blood culture was identified as S paucimobilis, which was sensitive to the antibiotics being administered. S paucimobilis infections have favorable prognosis, and at outpatient visit, our patient had revealed no sequela. Copyright © 2012 by Lippincott Williams & Wilkins.


PubMed | Dr Behcet Uz Child Disease And Pediatric Surgery Training And Research Hospital
Type: Case Reports | Journal: Neurosciences (Riyadh, Saudi Arabia) | Year: 2010

Acute disseminated encephalomyelitis (ADEM) is an acute demyelinating infection of the CNS that is characterized by multifocal white matter involvement often following an infection and vaccination. A 16-year-old child receiving risperidone for 7 years for the treatment of attention-deficit/hyperactivity disorder was hospitalized with complaints of double-vision during the past month and weakness on his right side, ataxia, and vomiting over the past 3 days. The child was diagnosed with ADEM after clinical, laboratory, and cranial MRI was conducted. Following an initial 3-day therapy with pulsed methylprednisolone, the child showed obvious clinical improvement. The treatment was continued with prednisolone and significant improvement was achieved. Enterovirus was detected in the results of the viral examination of the CSF. This child was found to be an interesting case having been diagnosed with ADEM associated with enteroviral infection, because of the rarity of few case reports in the literature.


PubMed | Dr Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital
Type: | Journal: TheScientificWorldJournal | Year: 2012

Brain-derived factor (BDNF) is a member of neurotrophin family and is localized and upregulated in areas implicated in epileptogenesis. Several lines of evidence make the BDNF gene a plausible candidate gene for predisposition to epilepsy. In this study, we tested that BDNF might be involved in the etiology of childhood PE. To assess whether BDNF gene C270T polimorphism could be implicated in vulnerability to PE, we conducted a case-control association analysis (112 partial epileptic and 100 controls) in Turkish children. Epileptic children were divided into two groups: 1--idiopathic (n = 85) and 2--symptomathic epilepsy (n = 27). There was no significant difference in genotypic distribution and allelic frequencies of the BDNF gene C270T polimorphism between the PE and control groups. However, the BDNF gene TT genotype was more frequently seen in the epileptic children (15 versus 11 patients, resp.). Interestingly, in the epilepsy group, both two children with TT genotype have posttraumatic epilepsy. The data indicate a possible association with the 270T genotype of the BDNF gene with a posttraumatic epilepsy. To draw any conclusion, further studies using larger sample sizes should be carried out in various ethnic populations in childhood epilepsies.


Yalcin O.,Bogazici University | Baykan B.,Istanbul University | Agan K.,Marmara University | Yapici Z.,Istanbul University | And 15 more authors.
Epilepsia | Year: 2011

To further evaluate the previously shown linkage of absence epilepsy (AE) to 2q36, both in human and WAG/Rij absence rat models, a 160-kb region at 2q36 containing eight genes with expressions in the brain was targeted in a case-control association study involving 205 Turkish patients with AE and 219 controls. Methods: Haplotype block and case-control association analysis was carried out using HAPLOVIEW 4.0 and inhibin alpha subunit (INHA) gene analysis by DNA sequencing. Key Findings: An association was found between the G allele of rs7588807 located in the INHA gene and juvenile absence epilepsy (JAE) syndrome and patients having generalized tonic-clonic seizures (GTCS) with p-values of 0.003 and 0.0002, respectively (uncorrected for multiple comparisons). DNA sequence analysis of the INHA gene in 110 JAE/GTCS patients revealed three point mutations with possible damaging effects on inhibin function in three patients and the presence of a common ACTC haplotype (H1) with a possible dominant protective role conferred by the T allele of rs7588807 with respective p-values of 0.0005 and 0.0014. Significance: The preceding findings suggest that INHA could be a novel candidate susceptibility gene involved in the pathogenesis of JAE or AE associated with GTCS. © Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.

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