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Albayrak M.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Balcik O.S.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Dagda S.,Ankara Numune Education and Research Hospital | Yilmaz M.,Ankara Numune Education and Research Hospital | And 3 more authors.
Turkish Journal of Hematology | Year: 2010

Objective: The plasminogen activator system consists of the serine protease urokinase plasminogen activator. (uPA), two endogenous inhibitors of PAI-1 (plasminogen activator inhibitor-1) as well as the PAI-2 and uPA. receptor (uPAR or CD87). The aim of this study was to determine the significance of flow cytometry and CD87, CD45 and CD56 expressions in the diagnosis, follow-up and prognosis of multiple myeloma (MM). Materials and Methods: Twenty-nine MM patients were included in the study. Bone marrow samples. were used for flow cytometry. A panel of CD87, CD45, CD56, CD10, CD19, CD20, CD38, and CD138 was tested by flow cytometry. Results: CD87 was negative in 8 (27.5%) cases, dim positive in 9 (31.1%) and bright positive in 12 (41.4%). CD87 expression was significantly higher in CD45 (-) cases. Conclusion: Flow cytometry has a significant role in the diagnosis and prognosis of MM. Further clinical studies including large numbers of patients are needed to determine the prognostic role of CD87 in MM.


Coskun M.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Soykut E.D.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Guney Y.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Karakaya E.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | And 3 more authors.
Turkiye Klinikleri Journal of Medical Sciences | Year: 2013

While metastasis to the brain is a well known and common complication of breast cancer, metastatic spread to the pituitary gland, specifically to the area of infundibulum is a rare presentation. In symptomatic cases, the most common manifestation of an infundibular metastatic lesion is diabetes insipidus (DI). Management of lesions in this area is controversial. Here, we presented a patient with symptomatic solitary infundibulum metastasis originating from breast cancer and the results of fractionated stereotactic radiotherapy (FSRT). The tumor size regressed and her symptoms decreased after the delivery of FSRT. The patient died due to the progression of systemic disease seven months after the FSRT. © 2013 by Türkiye Klinikleri.


Uslu N.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Karakaya E.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Dizman A.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Yegen D.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Guney Y.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital
Journal of Neurosurgery: Pediatrics | Year: 2013

In the current report, the authors present a case of optic nerve glioma treated with fractionated stereotactic radiotherapy (FSRT). An 11-year-old girl was referred to our clinic with increasing proptosis over a 1-year period. At that time orbital MRI revealed a 20 x 17-mm mass in the right retroorbital lipomatous tissue, and FSRT was delivered to the tumor using the CyberKnife. During the 1.5-year follow-up, ophthalmological examinations did not indicate any treatment-related severe toxicity, and posttreatment MRI demonstrated marked regression of the lesion to 13 x 10 mm. Given the scarcity of reports on this subject, the authors support more extended studies of the CyberKnife for the effective treatment of this relatively common childhood tumor. ©AANS, 2013.


Delikgoz soykut E.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Guney Y.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Aytac Arslan S.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Karakaya E.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Yegen D.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital
Turkiye Klinikleri Journal of Medical Sciences | Year: 2013

Orbital pseudotumor is a rare tumor of orbit which concerns a benign inflammatory process with an unknown etiology. They account for up to 10% of orbital masses and can involve any part of the orbit. Systemic steroids are the accepted as first line treatment modality. External beam radiation therapy has a well defined role in cases of failure, recurrences, persistent disease or medical contraindications for administration steroids. Management of orbital pseudotumors with stereotactic robotic radiotherapy was evaluated in a few studies. We aimed to describe a case involving the management of an orbital pseudotumor with the use of fractionated stereotactic radiotherapy using the CyberKnife® (Accuray Inc., Sunnyvale, CA). © 2013 by Türkiye Klinikleri.


Aribas B.K.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Arda K.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Ciledag N.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Aktas E.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital | Cetindag M.F.,Dr Abdurrahman Yurtarslan Ankara Oncology Education And Research Hospital
Asia-Pacific Journal of Clinical Oncology | Year: 2011

Aim: To determine the factors for predicting malignant diagnosis and limitations in ultrasonography guided fine-needle aspiration cytology of central and lateral cervical lymph nodes in patients with primary differentiated thyroid papillary carcinoma. Methods: Biopsies of cervical lymph nodes were performed in 120 patients, 31 of whom had subsequent surgical diagnoses. Factors examined were patient's age and gender of the patients, location (central and lateral compartments), hypoechogenicity with loss of hilum, microcalcification, cystic feature, minimum and maximum diameters and index value (minimum/maximum diameter). Results: The mean minimum diameter and index value of the lymph nodes were 9.9±4.9 mm and 0.60±0.19, respectively. Microcalcifications and cystic parts were specific findings with rates of 93.9% and 95.1%, respectively. Microcalcification, cystic feature, minimum diameter and index value were poor predictors of malignancy. The predictors were central location (P=0.031) and hypoechogenicity with loss of hilum in lateral neck (P=0.019). Central nodes led to a major problem for biopsy success due to postoperative changes and anatomic position. Nondiagnostic (30%) nodes were therefore mostly central. Conclusion: The involvement of the central neck should be a major indication of lymph node biopsy and pathological diagnosis regardless of the imaging findings. In the lateral compartment, hypoechogenicity with loss of hilum, microcalcifications, cystic parts and an index value≥0.51 are indications of a lymph node biopsy to rule out malignancy. © 2011 Blackwell Publishing Asia Pty Ltd.

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