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Seltmann J.,TU Chemnitz | Muller K.,TU Chemnitz | Klein S.,Down The Avenue | Lehmann M.,University of Wurzburg | Lehmann M.,TU Chemnitz
Chemical Communications | Year: 2011

V-shaped nematogens 1a-c and 2a-b with benzodithiophene bending units have been synthesised. The derivatives 1a-c comprise a flat core with a bending angle of 109°, which is almost the tetrahedral angle proposed to be optimal in the realization of mesogens forming a biaxial nematic thermotropic mesophase. © 2011 The Royal Society of Chemistry.

Pearson S.,Down The Avenue
Communications in Computer and Information Science | Year: 2010

This paper shows how a combination of usability and heuristics can be used to reduce complexity for privacy experts who create and maintain the knowledge base of a decision support system. This system helps people take privacy into account during decision making without being overwhelmed by the complexity of different national and sector-specific legislation. © Springer-Verlag Berlin Heidelberg 2010.

Pearson S.,Down The Avenue | Tsiavos P.,The Innovation Group
CLOSER 2012 - Proceedings of the 2nd International Conference on Cloud Computing and Services Science | Year: 2012

As cloud computing is evolving towards an ecosystem of service provision, in order for end users and customers to retain choice and control, they need to be able to select services, specify their preferences and have these reflected within the contractual framework, ideally enforced via a combination of legal and technical means. This paper presents an approach that builds upon successful methods from initiatives such as Creative Commons in order to improve the process of providing consent for usage of a data subject's personal data, and for achieving an appropriate balance between complexity and simplicity. This approach enhances the notices provided by service providers to advocate Smart Notices that provide a simple and transparent way of expressing the terms of service and the options available to the data subject before they share personal information with cloud service providers.

Busciglio J.,University of California at Irvine | Capone G.,Kennedy Krieger Institute | O'Byran J.P.,University of Illinois at Chicago | Gardiner K.J.,Down The Avenue
Cytogenetic and Genome Research | Year: 2013

Down syndrome (DS) is caused by an extra copy of all or part of the long arm of human chromosome 21 (HSA21). While the complete phenotype is both complex, involving most organs and organ systems, and variable in severity among individuals, intellectual disability (ID) is seen in all people with DS and may have the most significant impact on quality of life. Because the worldwide incidence of DS remains at approximately 1 in 1,000 live births, DS is the most common genetic cause of ID. In recent years, there have been important advances in our understanding of the functions of genes encoded by HSA21 and in the number and utility of in vitro and in vivo systems for modeling DS. Of particular importance, several pharmacological treatments have been shown to rescue learning and memory deficits in one mouse model of DS, the Ts65Dn. Because adult mice were used in the majority of these experiments, there is considerable interest in extending the studies to human clinical trials, and a number of trials have been completed, are in progress or are being planned. A recent conference brought together researchers with a diverse array of expertise and interests to discuss (1) the functions of HSA21 genes with relevance to ID in DS, (2) the utility of model systems including Caenorhabditis elegans , zebrafish and mouse, as well as human neural stem cells and induced pluripotent stems cells, for studies relevant to ID in DS, (3) outcome measures used in pharmacological treatment of mouse models of DS and (4) outcome measures suitable for clinical trials for cognition in adults and children with DS. © 2013 S. Karger AG, Basel.

Klein S.,Down The Avenue
HP Laboratories Technical Report | Year: 2013

We are in the middle of another revolution in information processing and distribution. After the invention of script and then print, pictures are taking over again. The number of gadgets with displays is larger than the world population. On average every single person on earth owns at least one device with a display on it. These displays are the portals to everything we do: communicating, reading, shopping, learning etc. But are they up to the job? The most successful display technology to date is still the liquid crystal display. It is a well established technology which can be scaled in size from small to large and, depending on the drive electronics, has no significant inherent limits to resolution. However, poor light efficiency and data congestion caused by high pixel densities are still technical challenges in need of good solutions. Could electrophoresis in a liquid crystal host be the answer? The fundamental basics and technical challenges of this interesting new approach will be discussed. © Copyright 2013 Liquid Crystals Reviews.

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