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McCabe L.L.,Down The Avenue | McCabe L.L.,University of Colorado at Denver | McCabe E.R.B.,Down The Avenue | McCabe E.R.B.,University of Colorado at Denver
Genetics in Medicine | Year: 2011

Experts agree that coercion by insurance companies or governmental authorities to limit reproductive choice constitutes a eugenic practice. We discuss discrimination against families of children with Down syndrome who chose not to have prenatal testing or chose to continue a pregnancy after a prenatal diagnosis. We argue that this discrimination represents economic and social coercion to limit reproductive choice, and we present examples of governmental rhetoric and policies condoning eugenics and commercial policies meeting criteria established by experts for eugenics. Our purpose is to sensitize the clinical genetics community to these issues as we attempt to provide the most neutral nondirective prenatal genetic counseling we can, and as we provide postnatal care and counseling to children with Down syndrome and their families. We are concerned that if eugenic policies and practices targeting individuals with Down syndrome and their families are tolerated by clinical geneticists and the broader citizenry, then we increase the probability of eugenics directed toward other individuals and communities. © 2011 Lippincott Williams & Wilkins.


Thomas M.R.,University of Bristol | Klein S.,Down The Avenue | Greasty R.J.,Hh Wills Physics Laboratory | Mann S.,University of Bristol | And 2 more authors.
Advanced Materials | Year: 2012

Self-assembled disc-shaped clusters of hexagonally packed, thiol-functionalized gold nanorods are prepared and dispersed in thermotropic nematic liquid crystals. The resultant hybrid complex fluids exhibit colloidal anisotropy with very high orientational order and are characterized by SAXS as shown in the figure. Precise, reconfigurable control of the cluster orientation at very low electric field strengths (0.18 V μm-1) is achieved. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Pearson S.,Down The Avenue | Tsiavos P.,The Innovation Group
CLOSER 2012 - Proceedings of the 2nd International Conference on Cloud Computing and Services Science | Year: 2012

As cloud computing is evolving towards an ecosystem of service provision, in order for end users and customers to retain choice and control, they need to be able to select services, specify their preferences and have these reflected within the contractual framework, ideally enforced via a combination of legal and technical means. This paper presents an approach that builds upon successful methods from initiatives such as Creative Commons in order to improve the process of providing consent for usage of a data subject's personal data, and for achieving an appropriate balance between complexity and simplicity. This approach enhances the notices provided by service providers to advocate Smart Notices that provide a simple and transparent way of expressing the terms of service and the options available to the data subject before they share personal information with cloud service providers.


Seltmann J.,TU Chemnitz | Muller K.,TU Chemnitz | Klein S.,Down The Avenue | Lehmann M.,University of Würzburg | Lehmann M.,TU Chemnitz
Chemical Communications | Year: 2011

V-shaped nematogens 1a-c and 2a-b with benzodithiophene bending units have been synthesised. The derivatives 1a-c comprise a flat core with a bending angle of 109°, which is almost the tetrahedral angle proposed to be optimal in the realization of mesogens forming a biaxial nematic thermotropic mesophase. © 2011 The Royal Society of Chemistry.


May K.,Otto Von Guericke University of Magdeburg | Stannarius R.,Otto Von Guericke University of Magdeburg | Klein S.,Down The Avenue | Eremin A.,Otto Von Guericke University of Magdeburg
Langmuir | Year: 2014

We report a reversible phase separation phenomenon in nonpolar colloidal suspensions of rod-shaped dichroic pigment particles in an electric field. The voltage-frequency phase diagram features a variety of phases with different morphologies. Single static particle-rich islands, chains of islands, and dynamic patterns were found in this system. We demonstrate that those patterns exhibit complex relaxation dynamics toward the homogeneous field-free state once the external field is removed. © 2014 American Chemical Society.


Busciglio J.,University of California at Irvine | Capone G.,Kennedy Krieger Institute | O'Byran J.P.,University of Illinois at Chicago | Gardiner K.J.,Down The Avenue
Cytogenetic and Genome Research | Year: 2013

Down syndrome (DS) is caused by an extra copy of all or part of the long arm of human chromosome 21 (HSA21). While the complete phenotype is both complex, involving most organs and organ systems, and variable in severity among individuals, intellectual disability (ID) is seen in all people with DS and may have the most significant impact on quality of life. Because the worldwide incidence of DS remains at approximately 1 in 1,000 live births, DS is the most common genetic cause of ID. In recent years, there have been important advances in our understanding of the functions of genes encoded by HSA21 and in the number and utility of in vitro and in vivo systems for modeling DS. Of particular importance, several pharmacological treatments have been shown to rescue learning and memory deficits in one mouse model of DS, the Ts65Dn. Because adult mice were used in the majority of these experiments, there is considerable interest in extending the studies to human clinical trials, and a number of trials have been completed, are in progress or are being planned. A recent conference brought together researchers with a diverse array of expertise and interests to discuss (1) the functions of HSA21 genes with relevance to ID in DS, (2) the utility of model systems including Caenorhabditis elegans , zebrafish and mouse, as well as human neural stem cells and induced pluripotent stems cells, for studies relevant to ID in DS, (3) outcome measures used in pharmacological treatment of mouse models of DS and (4) outcome measures suitable for clinical trials for cognition in adults and children with DS. © 2013 S. Karger AG, Basel.


Baumer N.,Down The Avenue | Davidson E.J.,Down The Avenue
Current Opinion in Pediatrics | Year: 2014

PURPOSE OF REVIEW: To review clinical updates and current healthcare issues for adolescents with Down syndrome and intellectual disabilities, including behavioral, social, and emotional issues, health supervision recommendations, and recommendations for supporting the transition process. RECENT FINDINGS: Several recent findings merit particular attention: low activity levels and implications for overweight and poor bone density; high prevalence of obstructive sleep apnea and its implications; prevalence of mental health and behavioral concerns; and need for appropriate transition services. SUMMARY: In guiding adolescents with Down syndrome towards healthy productive adult lives, clinicians can make use of healthcare guidelines and should also take a broader, more interdisciplinary approach to ensure that social, educational, and vocational plans are in place to support physical and mental health and development during transition into adulthood. Many of these issues have broader applicability to any adolescent with an intellectual disability. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.


Pearson S.,Down The Avenue
Communications in Computer and Information Science | Year: 2010

This paper shows how a combination of usability and heuristics can be used to reduce complexity for privacy experts who create and maintain the knowledge base of a decision support system. This system helps people take privacy into account during decision making without being overwhelmed by the complexity of different national and sector-specific legislation. © Springer-Verlag Berlin Heidelberg 2010.


Mowbray M.,Down The Avenue | Pearson S.,Down The Avenue | Shen Y.,Down The Avenue
Journal of Supercomputing | Year: 2012

In this paper, we describe a privacy manager for cloud computing that controls policy-based obfuscation and de-obfuscation of personal, sensitive, or confidential data within cloud service provision. By these means, cloud computing users may reduce the risk of their private data being stolen or misused, and in addition assistance may be given to cloud computing providers in helping them conform to privacy law. We describe different possible architectures for such privacy management in cloud computing, give an algebraic description of obfuscation features provided by the privacy manager, and describe how policies may be defined to control such obfuscation. Furthermore, we assess the performance and scalability of this approach and consider mechanisms to enhance usability. Several examples of how the privacy manager might be used are given, including protection of private metadata associated with online photos and of confidential information contained within share portfolios. © 2012 Springer Science+Business Media, LLC.


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