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The Dow University of Health science , is a public research university located in urban metropolitan area of Karachi, Sindh, Pakistan. The university comprises two leading health science research institutes: Medical College and Dow International Medical College.Foundation and establishment in 1945, it is known for its strong emphasis on biomedical, health, and medical research programmes. It is one of the premium institution of higher learning in Pakistan, and ranked among one of the top medical schools by HEC in 2010. The university is named after its founder, Sir Hugh Dow, who laid the foundation of the institution in 1945. The institution offers undergraduate, post-graduate and doctoral programmes in almost all academic disciplines relating to medical science.Major initiatives were personally taken by Ishrat-ul-Ibad who secured its major funding endowment in 2002. The university's objectives are keen towards helping its students to strives to develop better communication skills to communicate with their patients and prepare its students for a meritorious professional career. Wikipedia.


Sheikh A.,Dow University of Health Sciences
Diabetology and Metabolic Syndrome | Year: 2013

Current gold standard therapeutic strategies for T2DM target insulin resistance or β cell dysfunction as their core mechanisms of action. However, the use of traditional anti-diabetic drugs, in most cases, does not significantly reduce macrovascular morbidity and mortality. Among emerging anti-diabetic candidates, glucagon like peptide-1 (GLP-1) based therapies carry special cardiovascular implications, exerting both direct as well as indirect effects. The direct cardiovascular effects of GLP-1 and its analogs remain the focus of this review. © 2013 Sheikh; licensee BioMed Central Ltd. Source


Khan M.S.,Dow University of Health Sciences
Global journal of health science | Year: 2014

There are two basic ways of performing coronary artery bypass graft surgery (CABG): on pump CABG and off pump CABG. Off pump CABG is relatively a newer procedure to on-pump CABG and does not require the use of the cardiopulmonary bypass machine. On pump CABG is the more traditional method of performing bypass surgery. However its resultant inflammatory effects cause renal dysfunction, gastrointestinal distress and cardiac abnormalities which have forced the surgeons to look for alternatives to the procedure. An extensive literature search revealed that on pump CABG causes better revascularization as compared to off pump CABG while off pump CABG has a much lower post operative morbidity and mortality especially in high risk patients. We suggest that the technique used should depend on the ease of the surgeon doing the operation as both the methods seem almost equally efficient according to the review. Source


Hanif H.M.,Dow University of Health Sciences
Journal of the Pakistan Medical Association | Year: 2011

Maternal age at conception has long been demonstrated to have a significant correlation with pregnancy outcome and maternal health. Classically, very young (<20 years old) and old (= or >35 years) women have been classified as high-risk categories for child bearing. Recently, career, education, financial, and other goals have coerced women to delay childbearing all over the world. This trend is also becoming apparent in Pakistan, especially in the upper middle class, wealthy and educated women, as they become increasingly empowered. This review presents the association between maternal age and pregnancy outcome, particularly in the context of statistics of Pakistan, and its possible repercussions. On one hand, physicians need to develop effective counseling strategies for their patients in this regard, and on the other, more studies are required to ascertain the attitudes of Pakistani women, particularly those belonging to the upper and middle classes, regarding delayed childbearing, that can aid physicians in formulating effective counseling strategies. Source


Siddiqui S.A.,Dow University of Health Sciences
Annals of Saudi Medicine | Year: 2013

BACKGROUND AND OBJECTIVES: The trial of labor after previous cesarean (TOLAC) is an important strategy to limit repeat cesarean sections and their complications. An unsuccessful TOLAC leads to maternal and neonatal morbidities. The success or failure of TOLAC after the first cesarean is determinant for the subsequent vaginal birth. Limited studies are available from low-income countries, exclusively conducted in women in their second-order birth following the first cesarean section. This study aims at determining the frequency of unsuccessful attempts at vaginal delivery in the second-order term (37-41+6/7 weeks) birth among women with previous cesarean sections and to describe maternal and obstetric factors for unsuccessful laborTOLACs in the same group. DESIGN AND SETTINGS: A cross-sectional study conducted from April to December 2010 at Obstetrics & Gynaecology Unit II, Civil Hospital Karachi. PATIENTS AND METHODS: All eligible patients at term pregnancy in their second-order birth were included. The frequency of unsuccessful attempts at vaginal birth was determined, followed by secondary analysis by calculating odds ratio for maternal and obstetric factors, that is, body mass index (BMI), hight, gestation ≥40 weeks, interdelivery interval, engagement of head in 5th, estimated fetal weight, ruptured membranes, duration of labor ≥7 hours, augmentation of labor, cervical dilatation <4 cm, and vertex station -2 or higher on admission. RESULTS: Out of 122 study subjects, the proportion of unsuccessful vaginal birth after cesarean (VBAC) was 27.9% (n=34). Among maternal and obstetric factors, BMI >25 (AOR, 5.00), gestation ≥40 weeks (AOR, 5.45), cervical dilatation <4 cm (AOR, 5.90), and station of vertex -2 or higher (AOR, 3.83) had highly significant adjusted odds for failed TOLAC. CONCLUSION: With a well-defined protocol, the rates of unsuccessful attempts at VBAC are not high for the second-order birth. The risk of failure can be anticipated by factors such as BMI >25, pregnancy duration ≥40 weeks, cervical dilatation <4 cm, and vertex station -2 or higher on admission. Source


Hossain N.,Dow University of Health Sciences | Paidas M.J.,Yale University
Seminars in Perinatology | Year: 2013

Disseminated intravascular coagulation in obstetrics is commonly seen associated with massive hemorrhage due to different etiological factors. It may also be seen with intrauterine demise, infections, and hepatic conditions. It is associated with very high maternal and perinatal morbidity and mortality. A battery of laboratory tests (prothrombin time, partial thromboplastin time, thrombin time, and plasma fibrinogen) can be used in the diagnosis, but no single test in isolation is sensitive and specific enough for diagnosis. Cornerstone of management is to identify the underlying pathology for disseminated intravascular coagulation. This chapter looks into molecular basis of obstetric DIC and identifies important laboratory tests, along with management. It also identifies topics of future research in the field of obstetric DIC. © 2013 Elsevier Inc. Source

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