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Kyoto, Japan

Doshisha University , also referred to as Dodai , is a private university in Kyoto City, Japan. Established in 1875, it is one of the oldest private institutions of higher learning in Japan, and has approximately 30,000 students enrolled on four different campuses in Kyoto. It is one of the Japanese "Global 30" universities and one of the "Kankandoritsu," a group of the four leading private universities in the Kansai region of western Japan.Doshisha was founded by Joseph Hardy Neesima as "Doshisha English School", and in 1920 it was granted university status. The university now encompasses 14 faculties and 16 graduate schools with numerous affiliated institutions including Doshisha Women's College of Liberal Arts. Wikipedia.

Tatsuki S.,Doshisha University
Earthquake Spectra

Since the Evacuation/Sheltering Guideline was first published in March 2005, Japan has been a leader in systematically promoting evacuation and shelter assistance initiatives for people with special needs (PSND) in times of disasters. Despite the nationwide, community-based initiatives prescribed by the Guideline, this paper first addresses the issue of evacuation by examining mortality data of the total population, the elderly, and people with disabilities (PWD). The elderly and PWD mortality rates were not even across the three disaster-hit prefectures. Their institutionalization rate was suggested as one of the causative factors; more elderly and PWD died in Miyagi because more of them resided in their own homes, due to the prefecture's socially inclusive normalization policy. A case study of Miyagi's Hachiman community responses to its 17 registered PSND illustrated the ways to overcome the issue of mainstreaming preparedness components in the everyday practice of social inclusion for the elderly and PWD. © 2013, Earthquake Engineering Research Institute. Source

Nishikawa K.,Doshisha University
Archivum Immunologiae et Therapiae Experimentalis

Infection with Shiga toxin (Stx)-producing Escherichia coli (STEC), including O157:H7, causes bloody diarrhea and hemorrhagic colitis in humans, occasionally resulting in fatal systemic complications, such as neurological damage and hemolytic-uremic syndrome. Because Stx is a major virulence factor of the infectious disease, a series of Shiga toxin neutralizers with various structural characteristics has been developed as promising therapeutic agents. Most of these agents function to bind to the toxin directly and inhibit the binding to its receptor present on the target cells. Other neutralizers do not inhibit receptor binding but induce aberrant intracellular transport of the toxin, resulting in effective detoxification. Such a novel type of Stx neutralizer provides a new therapeutic strategy against STEC infections. Here, recent progress of the development of Stx neutralizers is reviewed. © 2011 L. Hirszfeld Institute of Immunology and Experimental Therapy. Source

Yokoyama N.,Kyoto University | Takaoka M.,Doshisha University
Physical Review Letters

A variety of statistically steady energy spectra in elastic wave turbulence have been reported in numerical simulations, experiments, and theoretical studies. Focusing on the energy levels of the system, we perform direct numerical simulations according to the Föppl-von Kármán equation, and successfully reproduce the variability of the energy spectra by changing the magnitude of external force systematically. When the total energies in wave fields are small, the energy spectra are close to a statistically steady solution of the kinetic equation in the weak turbulence theory. On the other hand, in large-energy wave fields, another self-similar spectrum is found. The coexistence of the weakly nonlinear spectrum in large wave numbers and the strongly nonlinear spectrum in small wave numbers is also found in moderate energy wave fields. © 2013 American Physical Society. Source

Saito Y.,Doshisha University
Journal of Clinical Biochemistry and Nutrition

Parkinson's disease is a progressive, age-related, neurodegenerative disorder, and oxidative stress is an important mediator in its pathogenesis. DJ-1 is a causative gene of a familial form of Parkinson's disease, namely PARK7, and plays a significant role in antioxidative defense to protect the cells from oxidative stress. DJ-1 undergoes preferential oxidation at the cysteine residue at position 106, Cys-106, under oxidative stress. The critical role of Cys-106 in the biological function of DJ-1 has been demonstrated, and recent studies indicate that DJ-1 acts as a sensor of oxidative stress by regulating the gene expression of antioxidative defense. Specific antibodies against Cys-106-oxidized DJ-1 have been developed, and the generation of oxidized DJ-1 in cellular and animal models of Parkinson's disease has been investigated. This review focuses on the role of DJ-1 in antioxidative defense and the importance of oxidizable Cys-106 in its function. The signifi- cance of the identification of early-phase Parkinson's disease biomarkers and the nature of oxidized DJ-1 as a biomarker for Parkinson's disease are discussed here. ©2014 JCBN. Source

Hanabusa K.,Doshisha University
Renewable and Sustainable Energy Reviews

The aim of this paper is to show the influence of the 107th OPEC Ordinary Meeting (meeting) and investigates the relationships between oil prices and economic activities, using an exponential generalized autoregressive conditional heteroskedasticity (EGARCH) and a vector autoregressive (VAR) model from 1991 to 2008 in Japan. We find that levels and volatilities of oil prices increase after the meeting. We examine the effects of it on Japanese economic activities, employing a Granger-causality test and data before and after it. The empirical result reveals that each price of regular gasoline and diesel has information to be useful to predict the economy after the meeting. On the other hand, volatilities of regular gasoline and diesel price have information to predict the inflation and economic growth before the meeting, respectively. After the meeting, however, these volatilities change to be useful to predictive both inflation and economic growth. Thus, we conclude that the decision of meeting is related to not only the domestic oil prices, but also the macroeconomy. © 2011 Elsevier Ltd. All rights reserved. Source

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