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Québec, Canada

Doric Lenses Inc. | Date: 2011-11-23

The hybrid fiber-optic cannula can have a body having an implant end, a light passage extending through the body, and a light inlet end coinciding with the light passage, an optical fiber held in the body in coincidence with the light passage and oriented out the implant end, the light inlet end being opposite the implant end relative to the light passage, and a conduit extending through the body between a conduit outlet located at the implant end and a conduit inlet. A fluid and/or electrical wires, can be conveyed by the conduit, for instance.

Gagnon-Turcotte G.,Laval University | Kisomi A.A.,Laval University | Ameli R.,Laval University | Camaro C.-O.D.,Laval University | And 8 more authors.
Sensors (Switzerland)

We present a small and lightweight fully wireless optogenetic headstage capable of optical neural stimulation and electrophysiological recording. The headstage is suitable for conducting experiments with small transgenic rodents, and features two implantable fiber-coupled light-emitting diode (LED) and two electrophysiological recording channels. This system is powered by a small lithium-ion battery and is entirely built using low-cost commercial off-the-shelf components for better flexibility, reduced development time and lower cost. Light stimulation uses customizable stimulation patterns of varying frequency and duty cycle. The optical power that is sourced from the LED is delivered to target light-sensitive neurons using implantable optical fibers, which provide a measured optical power density of 70 mW/mm2at the tip. The headstage is using a novel foldable rigid-flex printed circuit board design, which results into a lightweight and compact device. Recording experiments performed in the cerebral cortex of transgenic ChR2 mice under anesthetized conditions show that the proposed headstage can trigger neuronal activity using optical stimulation, while recording microvolt amplitude electrophysiological signals. © 2015 by the authors; licensee MDPI, Basel, Switzerland. Source

Ameli R.,Laval University | Mirbozorgi A.,Laval University | Neron J.-L.,Doric Lenses Inc | Lechasseur Y.,Doric Lenses Inc | Gosselin B.,Laval University
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

This paper presents a miniature Optogenetics headstage for wirelessly stimulating the brain of rodents with an implanted LED while recording electrophysiological data from a two-channel custom readout. The headstage is powered wirelessly using an inductive link, and is built using inexpensive commercial off-the-shelf electronic components, including a RF microcontroller and a printed antenna. This device has the capability to drive one light-stimulating LED and, at the same time, capture and send back neural signals recorded from two microelectrode readout channels. Light stimulation uses flexible patterns that allow for easy tuning of light intensity and stimulation periods. For driving the LED, a low-pass filtered digitally-generated PWM signal is employed for providing a flexible pulse generation method that alleviates the need for D/A converters. The proposed device can be powered wirelessly into an animal chamber using inductive energy transfer, which enables compact, light-weight and cost-effective smart animal research systems. The device dimensions are 15×25×17 mm; it weighs 7.4 grams and has a data transmission range of more than 2 meters. Different types of LEDs with different power consumptions can be used for this system. The power consumption of the system without the LED is 94.52 mW. © 2013 IEEE. Source

Gagnon-Turcotte G.,Laval University | LeChasseur Y.,Laval University | Bories C.,Doric Lenses Inc | De Koninck Y.,Doric Lenses Inc | Gosselin B.,Laval University
IEEE Biomedical Circuits and Systems Conference: Engineering for Healthy Minds and Able Bodies, BioCAS 2015 - Proceedings

This paper presents a multichannel wireless op-Togenetic headstage providing neural recording and optical stimulation capabilities simultaneously. The proposed headstage, which is entirely built using commercial off-The-shelf components, includes 32 electrophysiological recording channels and up to 32 high-power optical stimulation channels. It can process 32 neuronal signals in real-Time with high compression ratio using an embedded digital signal processor performing spike detection and data compression in-situ. The presented headstage is small and lightweight rendering it suitable for conducting in-vivo experiments with freely moving transgenic rodents. We report results obtained from in-vivo experiments showing that the proposed wireless headstage can collect, detect and compress the microvolts amplitude neuronal signals evoked by light stimulation with a high averaged peak-signal-To-noise ratio of 22.4 dB and a high averaged signal-To-noise distortion ratio of 17.0 dB. The design of this headstage is using a rigid-flex printed circuit board, resulting into a lightweight (2.8 g) and compact device (17×18×10 mm3). © 2015 IEEE. Source

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