Doon valley Institute of Pharmacy and Medicine
Doon valley Institute of Pharmacy and Medicine
Bansal S.,Himachal Pradesh University |
Bala M.,Jaipur National University |
Choudhary S.,Doon Valley Institute of Pharmacy and Medicine |
Bhattacharya S.,Himachal Pradesh University |
Singla S.,Rajendra Institute of Technology and science
European Journal of Medicinal Chemistry | Year: 2014
A novel series of 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4- oxadiazoles were designed and synthesized for selective COX-2 inhibition with potent anti-inflammatory activity. Among the compounds tested, 9g (2-(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-phenyl-1,3,4-oxadiazole) was found to be the most potent inhibitor of COX-2 with IC of 0.31 μM showing promising degree of anti-inflammatory activity in the carrageenan-induced rat paw edema model with ED of 74.3 mg/kg. The lead compound 9g further showed suppression of acetic acid-induced writhes comparable to that of aspirin and gastro-sparing profile superior to the aspirin. Molecular docking analysis displayed higher binding affinity of ligands towards COX-2 than COX-1. © 2014 Elsevier Masson SAS. All rights reserved.
Kannadasan M.,Dr K.N. Modi University |
Jain S.K.,Dr Hari Singh Gour University |
Roy R.K.,Doon Valley institute of Pharmacy and Medicine
Research Journal of Pharmacy and Technology | Year: 2014
The scientific research has been transformed from stone age–brass age–iron age–ceramic age–polymer age and now currently to graft polymer age. The natural polymer science and technology has developed tremendously over the last few decades, and the production of natural polymers based drug products has increased at a remarkable pace. Currently, interplay between natural and synthetic polymers is being emphasized to further advancing the drug delivery to second brain (colon). So, take a look at some surprising spinoff from this experimental study of copolymers, which are far more technically superior and reach to difficult to reach the place in gastro intestinal tract. © RJPT All right reserved.
Rawat S.,Himachal Institute of Pharmacy |
Singh R.,Himachal Institute of Pharmacy |
Thakur P.,Himachal Institute of Pharmacy |
Kaur S.,Doon valley Institute of Pharmacy and Medicine |
Semwal A.,Himachal Institute of Pharmacy
Asian Pacific Journal of Tropical Biomedicine | Year: 2012
This paper presents a review of plants identified from various ethno botanical surveys and folklore medicinal survey with Wound healing activity. Wound is defined as the disruption of the cellular and anatomic continuity of a tissue. Wound may be produced by physical, chemical, thermal, microbial or immunological insult to the tissues. The process of wound healing consists of integrated cellular and biochemical events leading to re-establishment of structural and functional integrity with regain of strength in injured tissues. This review discuss about Wound healing potential of plants, its botanicalname, Common name, family, part used and references, which are helpful for researcher to development new Wound healing formulations for human use. © 2012 Asian Pacific Tropical Biomedical Magazine.
Bansal S.,Ganpati Institute of Pharmacy |
Syan N.,Ganpati Institute of Pharmacy |
Mathur P.,Ganpati Institute of Pharmacy |
Choudhary S.,Doon Valley Institute of Pharmacy and Medicine
Medicinal Chemistry Research | Year: 2012
Tea (Camellia sinensis, Theaceae) is the second most consumed beverages in the world, next to water in terms of worldwide popularity. The chemical components of green tea chiefly include polyphenols, caffeine, and amino acids. Green tea is rich in catechins, of which (-)-epigallocatechin-3-gallate is the most abundant. As described in literature, green tea and its polyphenols are beneficial in curing a wide variety of diseases like cancer, diabetes, cardiovascular disease, obesity, etc. It also has antimicrobial activity, protects from solar radiations, and possesses neuroprotective properties. The current review article focuses on pharmacological profile associated with Green tea and its polyphenols. We hope that this review will expose areas for further study and encourage research on important public health issue. © Springer Science+Business Media, LLC 2011.
Rani R.,National Dairy Research Institute |
Kansal V.K.,National Dairy Research Institute |
Kansal V.K.,Doon Valley Institute of Pharmacy and Medicine
Indian Journal of Medical Research | Year: 2012
Background & objectives: Our previous study showed that cow ghee relative to soybean oil had a protective effect against carcinogen induced mammary cancer in rats. The objective of this study was to elucidate its biochemical mechanism. Methods: Two groups of 21 day old rats (20 each) were fed for 44 wk diet containing cow ghee or soybean oil (10%). Five animals from each group were sacrificed at 0 day and at 5, 21 and 44 wk for analysis of phase I and phase II pathways enzymes of carcinogen metabolism. Results: Dietary cow ghee relative to soybean oil decreased the activities of cytochrome P450 (CYP) enzymes, CYP1A1, CYP1A2, CYP1B1 and CYP2B1, responsible for activation of carcinogen in liver. Carcinogen detoxification activities of uridinediphospho-glucuronosyl transferase (UDPGT) and quinone reductase (QR) in liver, and γ-glutamyltranspeptidase (GGTP) and QR in mammary tissue were significantly higher in cow ghee fed rats than in soybean oil fed rats. The hepatic GGTP activity decreased on soybean oil diet; while in cow ghee group it remained unaffected. Interpretation & conclusions: Our findings show that dietary cow ghee compared to soybean oil downregulates the enzyme activities responsible for carcinogen activation in liver and upregulates carcinogen detoxification activities in liver and mammary tissues.