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Chu X.C.,Dongying Municipal Peoples Hospital | Cheng S.,Dongying Municipal Peoples Hospital | Yan S.Y.,Dongying Municipal Peoples Hospital
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: Stem cell transplantation has been shown to have many advantages in treatment of diseases. Its application can treat various diseases in many systems such as nervous system, immune system and endocrine system. Its advantage is incomparable. These are all credit to the special abilities, including easy sample collection, strong self proliferative ability, wide differentiation range, repair of injured tissue and immunoloregulation. OBJECTIVE: To explore the clinical effects of stem cell transplantation in treatment of nonunion. METHODS: A computer search was performed in CNKI database for articles concerning stem cell transplantation for nonunion published from 2005 to 2014. The key words were “stem cells, nonunion” in Chinese. 244 articles were analyzed, and typical literatures were further compared. RESULTS AND CONCLUSION: Stem cells have the abilities of self-renewal and differentiation. Their source is not limited, and the sample collection is convenient. Stem cells have small injury to the donor, do not have immunogenicity, and have fewer complications. The cost is low. Stem cells are easily isolated and cultured, can proliferate infinitely, and provide a pathway for severe bone injury such as nonunion, bone defects and comminuted fracture. The deep study of stem cells creates a new direction for nonunion treatment, and has achieved certain results in clinical trials.

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