Yin A.,University of Sichuan |
Luo R.,University of Sichuan |
Li J.,University of Sichuan |
Mo X.,Donghua UniversityShanghai |
And 2 more authors.
Colloids and Surfaces B: Biointerfaces | Year: 2017
Small diameter vascular grafts possessing desirable biocompatibility and suitable mechanical properties have become an urgent clinic demand. Herein, heparin loaded fibrous grafts of collagen/chitosan/poly(L-lactic acid-co-ε-caprolactone) (PLCL) were successfully fabricated via coaxial electrospinning. By controlling the concentration of heparin and the ratio of collagen/chitosan/PLCL, most grafts had the heparin encapsulation efficiency higher than 70%, and the heparin presented sustained release for more than 45 days. Particularly, such multicomponent grafts had relative low initial burst release, and after heparin releasing for 3 weeks, the grafts still showed good anti-platelet adhesion ability. In addition, along with the excellent cell biocompatibility, the fabricated grafts possessed suitable mechanical properties including good tensile strength, suture retention strength, burst pressure and compliance which could well match the native blood vessels. Thus, the optimized graft properties could be properly addressed for vascular tissue application via coaxial electrospinning. © 2017 Elsevier B.V.
Xiao Z.,Donghua UniversityShanghai |
Xiao Z.,Jiaxing University |
Jiang X.,Jiaxing University |
Li B.,Donghua UniversityShanghai |
And 7 more authors.
Nanoscale | Year: 2015
Metal oxides are receiving an incremental attention in recent years for their potential applications in ablation of cancer cells due to their efficient photothermal conversion and good biocompatibility, but the large sizes and poor photo-stability will seriously limit their practical application. Herein, hydrous RuO2 nanoparticles were synthesized by a facile hydrothermal treatment and surface-modified with polyvinylpyrrolidone (PVP) coating. PVP-coated RuO2 nanoparticles exhibit a well dispertion in saline solution, strong characteristic plasmonic absorption in NIR region, enhanced photothermal conversion efficiency of 54.8% and remarkable photo-stability under the irridation of an 808 nm laser. The nanoparticles were further employed as a new photothermal ablation agent for cancer cells which led rapidly to cellular deaths both in vitro and in vivo. This journal is © The Royal Society of Chemistry.
Ji B.,Donghua UniversityShanghai |
Ji B.,University of California at Davis |
Tang P.,Donghua UniversityShanghai |
Tang P.,University of California at Davis |
And 2 more authors.
Carbohydrate Polymers | Year: 2015
1,2,3,4-Butanetetracarboxylic acid (BTCA) reacts with cellulose in two steps with catalysis of alkaline salts such as sodium hypophosphite: anhydride formation and esterification of anhydride with cellulose. The alkali metal ions were found effective in catalyzing formation of BTCA anhydride in a previous report. In this work, catalytic functions of the alkaline salts in the esterification reaction between BTCA anhydride and cellulose were investigated. Results revealed that acid anions play an important role in the esterification reaction by assisting removal of protons on intermediates and completion of the esterification between cellulose and BTCA. Besides, alkaline salts with lower pKa1 values of the corresponding acids are more effective ones for the reaction since addition of these salts could lead to lower pH values and higher acid anion concentrations in finishing baths. The mechanism explains the results of FTIR and wrinkle recovery angles of the fabrics cured under different temperatures and times. © 2015 Elsevier Ltd.
Tan H.,Donghua UniversityShanghai |
Houpis I.,Janssen Pharmaceutical |
Liu R.,STA Pharmaceuticals |
Wang Y.,STA Pharmaceuticals |
Chen Z.,Donghua UniversityShanghai
Organic Letters | Year: 2015
A novel reactivity of sulfonylhydrazones under Pd catalysis is described, where SO2 and N2 are formally extruded to afford the product of an apparent internal coupling reaction. The reaction is effective with both carbocyclic and heterocyclic aromatic precursors. © 2015 American Chemical Society.
Yu L.,Donghua UniversityShanghai |
Wang R.,Donghua UniversityShanghai |
Wang R.,Polytechnic University of Mozambique |
Zhou J.,Donghua UniversityShanghai |
Xu B.,University of Texas at Austin
Journal of Microscopy | Year: 2016
For an automated microscopic imaging system, the image acquisition speed is one of the most critical performance features because many applications require to analyse high-volume images. This paper illustrates a novel approach for rapid acquisition of high-volume microscopic images used to count blood cells automatically. This approach firstly forms a panoramic image of the sample slide by stitching sequential images captured at a low magnification, selects a few basic points (x, y) indicating the target areas from the panoramic image, and then refocuses the slide at each of the basic points at the regular magnification to record the depth position (z). The focusing coordinates (x, y, z) at these basic points are used to calculate a predicted focal plane that defines the relationship between the focus position (z) and the stage position (x, y). Via the predicted focal plane, the system can directly focus the objective lens at any local view, and can tremendously save image-acquisition time by avoiding the autofocusing function. The experiments showed how to determine the optimal number of the basic points at a given imaging condition, and proved that there is no significant difference between the images captured using the autofocusing function or the predicted focal plane. © 2016 The Authors Journal of Microscopy © 2016 Royal Microscopical Society
Ke F.,Donghua UniversityShanghai |
Ke F.,George Washington University |
Qiu X.,George Washington University
Journal of Physical Chemistry C | Year: 2015
Condensation of DNA-carbon nanotube (CNT) hybrids dispersed in aqueous solutions can be induced by elevated hybrid concentrations, salts, or crowding agents. DNA-CNT condensates exhibit either nematic ordering or amorphous aggregates, dependent on the nature of interhybrid interactions. This study employed X-ray diffraction (XRD) to determine nanoscale structures of the condensates, including the presence of positional ordering, interaxial distances, and the range of ordered domains. To probe the effects of DNA sequence, two types of CNT hybrids, dispersed by genomic DNA of random sequence and synthetic oligonucleotides respectively, were studied under identical conditions. The osmotic stress method was further used to quantify force-distance dependencies of the DNA-CNT hybrids to elucidate the relation between interhybrid interactions and condensate structures. We observed that, independent of DNA sequence, lyotropic DNA-CNT phases showed weak positional ordering with long interhybrid distances, salt-induced condensates were amorphous, crowding-condensed DNA-CNTs were the most ordered with pronounced XRD peaks, and interhybrid interactions were defined by short-range hydration repulsion and long-range electrostatic repulsion. Conversely, the effects of DNA sequence became evident as to their quantitative force-distance relationships. Genomic DNA of random sequence consistently gave longer interhybrid distances than synthetic oligonucleotides, which we attribute to the likely differences in their hybrid diameters. © 2015 American Chemical Society.
Zuo W.,Chinese Academy of Sciences |
Zuo W.,CAS National Astronomical Observatories |
Zuo W.,University of Chinese Academy of Sciences |
Zhang Z.,Chinese Academy of Sciences |
And 8 more authors.
Computers and Geosciences | Year: 2016
In order to provide fundamental information for exploration and related scientific research on the Moon and other planets, we propose a new automatic method to recognize craters on the lunar surface based on contour data extracted from a digital elevation model (DEM). Through DEM and image processing, this method can be used to reconstruct contour surfaces, extract and combine contour lines, set the characteristic parameters of crater morphology, and establish a crater pattern recognition program. The method has been tested and verified with DEM data from Chang'E-1 (CE-1) and Chang'E-2 (CE-2), showing a strong crater recognition ability with high detection rate, high robustness, and good adaptation to recognize various craters with different diameter and morphology. The method has been used to identify craters with high precision and accuracy on the Moon. The results meet requirements for supporting exploration and related scientific research for the Moon and planets. © 2016 Elsevier Ltd