Seoul, South Korea
Seoul, South Korea

Dongguk University is a private, coeducational university in South Korea. It operates campuses in Seoul, Gyeongju City, North Gyeongsang province, and Los Angeles, United States. It operates two affiliated hospitals of Western medicine, and four of Oriental medicine, a generic term which includes traditional Korean medicine studies. Wikipedia.


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The present invention relates to a pharmaceutical composition containing a G protein coupled receptor 119 (GPR119) ligand as an active ingredient for preventing or treating non-alcoholic fatty liver disease. More particularly, it was confirmed that the GPR119 ligand, which has been developed as only an anti-diabetic drug, exhibits superior effects on the treatment of non-alcoholic fatty liver and the signal pathways in hepatocytes therefor differ from the signal pathways in the small intestine and the pancreas exhibiting anti-diabetic effects, whereby the GPR119 ligand can be useful to treat non-alcoholic fatty liver.


The present invention relates to a positive electrode active material for a lithium ion battery and, more specifically, to a positive electrode active material for a lithium ion battery, having improved initial capacitance and charging and discharging efficiency due to increased electrical conductivity or ion conductivity. The positive electrode active material for a lithium ion battery of the present invention contains lithium vanadium phosphate (Li_(3)V_(2)(PO_(4))_(3)) and lithium zirconium phosphate (Li_(3)Zr_(2)(PO_(4))_(3)) formed on an external surface of the lithium vanadium phosphate. The positive electrode active material for a lithium ion battery comprising lithium vanadium zirconium phosphate (Li_(3)V_(2-x)Zr_(x)(PO_(4))_(3)) particles, which is prepared by a preparation method of the present invention, has excellent structural stability and ion conductivity as well as high capacitance.


Disclosed are 4-substituted-2-(5-substituted-1H-indol-2-yl)phenol derivatives for controlling the proliferation and migration of kinase-overexpressed cells. The phenol derivatives are represented by Formula 1: wherein X is selected from the group consisting of hydrogen, halogen, a cyano group, a trifluoromethyl (CF_(3)) group, an amidine (C(NH)NH_(2)) group, and a 5-methyl-1,2,4-oxadiazole group, Y is selected from the group consisting of hydrogen, halogen, a phenyl group substituted with one or two substituents selected from the group consisting of halogen, methoxy, nitro, trifluoromethyl, and aminomethyl, COR, COOR, OH, OR, and NHR, each R is independently selected from the group consisting of C_(1)-C_(18 )alkyl, alkenyl, alkynyl, and Z-alkyl (wherein Z is a heteroatom selected from the group consisting of O, S, and N or is (CH_(2))_(m)), and m is an integer from 0 to 5. Also disclosed are methods for preparing the phenol derivatives and pharmaceutical compositions for inhibiting cell proliferation and migration including the phenol derivatives. The phenol derivatives and the pharmaceutical compositions can effectively inhibit the proliferation and migration of kinase-overexpressed cells and can be used for the prevention or treatment of various solid cancers and metastatic cancers.


The present invention relates to a carbon nanotube interlayer, a manufacturing method thereof, and a thin film transistor using the same. More specifically, the present invention provides a carbon nanotube interlayer, a manufacturing method thereof, and a thin film transistor using the same, where the carbon nanotube interlayer is a layer constituting an organic thin film transistor and comprising a conjugated polymer and a single-walled carbon nanotube between an organic semiconductor layer and a source/drain electrode. The conjugated polymer selectively wraps the single-walled carbon nanotube having semiconducting properties.


Provided is a pharmaceutical composition for preventing or treating liver fibrosis, comprising a GPR119 ligand as an active ingredient. The composition comprising the GPR119 ligand as an active ingredient significantly inhibits the expression of collagen I, transforming growth factor (TGF) and -smooth muscle actin (-SMA), thereby inhibiting HSC activation, and also significantly inhibits HSC proliferation. Therefore, the composition may be effectively applied in improvement, prevention, inhibition or treatment of liver fibrosis


News Article | April 20, 2017
Site: news.yahoo.com

FILE - In this April 7, 2017, file photo, U.S. President Donald Trump gestures as he and Chinese President Xi Jinping walk together after their meetings at Mar-a-Lago in Palm Beach, Fla. After decades of failure to stop North Korea’s march toward a nuclear arsenal, some see Trump’s bluster as a shrewd attempt to press China, the North’s most important ally and trading partner, into pressuring North Korea more aggressively over its nuclear program. (AP Photo/Alex Brandon, File) Many South Koreans are using those words to describe the president of their most important ally, rather than the leader of their archrival to the North. They worry that President Donald Trump's tough, unorthodox talk about North Korea's nuclear program is boosting already-high animosity between the Koreas. No matter whether Trump succeeds at getting North Korea to abandon its nuclear weapons and missile programs, his actions, comments and tweets are changing how the region views the long-running conflict. Senior North Korean officials see their relations with Washington as even more volatile than before. China is appealing for calm, and possibly re-examining its role. Japan is weighing a retaliatory strike capability against the North. After decades of failure to stop North Korea's march toward a nuclear arsenal, some see Trump's bluster as a shrewd attempt to press China, the North's most important ally and trading partner, into pressuring North Korea more aggressively over its nuclear program. Trump has said he's willing to make trade and economic concessions to China in return for its help with North Korea. "A trade deal with the U.S. will be far better for them if they solve the North Korean problem!" Trump said on Twitter, recounting what he told Xi while hosting him this month at his Palm Beach, Florida, resort. Pulling back from a campaign promise, Trump has also said he would not declare China a currency manipulator, as he looked for help from Beijing. The rhetoric seems to be blurring the lines between North Korea and economic ties with China, issues that previous U.S. administrations had kept separate. If such persuasion falls short, Trump has suggested he might use more coercive methods. So-called secondary sanctions on Chinese banks that do business with North Korea could also be in the offing, officials have said. "Trump is posing a hard choice to Beijing — do something, something about North Korea and hope it generates some effects, or face American economic retaliation," said Dean Cheng, senior research fellow at the Heritage Foundation in Washington, D.C. "Whether that works or not, it's a very different strategy from the last three presidents." Koh Yu-hwan, a North Korea expert at Seoul's Dongguk University, said that the way U.S. officials describe "maximum pressure and engagement" suggests that the Trump administration wants to ease Chinese fears about a collapse in North Korea, something that prevented Beijing from aggressively pressuring the North in the past. "If the United States and China can set the tone, there will also be more opportunities for dialogue. It seems Trump could be more willing to cut a deal with North Korea than Obama was," Koh said. South Koreans may be uneasy about North Korea's expanding arsenal of weapons, but many doubt that the country's leader, Kim Jong Un, wants to start a war that would likely end in the destruction of his government and the ruling elite. Donald Trump is another story, judging by widespread concern posted on Twitter. Some see him as a hot-tempered, unpredictable leader who might attack North Korea before it masters the technology to build a nuclear-tipped missile that could hit the U.S. mainland. North Korea is moving steadily toward that goal, and some experts believe it could achieve it during Trump's presidency. U.S. strikes earlier this month against Syria, coupled with Trump's dispatching of what he called an "armada" of U.S. warships to the Korean region, touched off fears that the United States was preparing for military action, though it was revealed this week that the flotilla was taking a roundabout path to Korean waters and has yet to arrive. Lim Eul Chul, a North Korea expert at South Korea's Kyungnam University, doesn't think Trump wants to attack North Korea but said he appears eager to send a message that war is possible. That has driven North Korea to issue its own threats and begin preparations for "even a 1 percent chance that the U.S. will launch pre-emptive strikes," Lim said. "That's just how the authoritarian Kim government survives." The Kyunghyang Shinmun newspaper said recently that Trump is playing a "dangerous card" with his verbal threats, risking a miscalculation by Pyongyang and a war on the peninsula. "Trump seems capable of doing anything, and he might choose to strike the North before it's technologically able to strike back," said Ray Kim, a 39-year-old Seoul resident. "Even if a war breaks out, it's not like that war will take place on U.S. soil. Trump has much less to lose." Trump is clearly on the mind of the North Korean leadership. A senior Foreign Ministry official told The Associated Press last week that Pyongyang has been watching Trump's actions — including his recent order for the strike on a Syrian air base and his many tweets about North Korea — and determined that his administration is "more vicious and more aggressive" than that of his predecessor, Barack Obama. In response, Pyongyang is promising it will continue to build up its "nuclear deterrent" and respond in kind to any hostile moves, perceived or real. North Korean fury at Washington was rising well before Trump took office, in particular over reports that annual U.S.-South Korean military exercises now include training for precision strikes on the North's leadership or nuclear and military facilities. Pyongyang's regime has called that "a red line," and has since begun its own training for pre-emptive strikes and speeded up its testing of nuclear weapons and long-range missiles. Japan is drawing up emergency responses in case of a North Korea missile strike. A number of municipalities are testing community alarm systems and planning evacuation drills as concerns run high around U.S. military bases. Both Japan and South Korea are home to tens of thousands of U.S. troops. The rising tension has opened the door to debate about once-taboo subjects in Japan, where the disastrous World War II experience and a postwar constitution that renounced the right to use military force have created a strong pacifist streak. Japan's ruling party recently urged the government to introduce advanced missile-defense equipment such as a land-based Aegis or Terminal High Altitude Area Defense (THAAD) system, which is being introduced in South Korea. Ruling party defense experts have even proposed that Japan lift a self-imposed restraint on conducting a retaliatory strike if attacked, rather than relying solely on the U.S. military. The steady turning up of the heat on all sides has increased the possibility of a miscalculation that could result in an incident that escalates too quickly to be contained, or even outright conflict. Associated Press Writers Eric Talmadge in Pyongyang, North Korea; Christopher Bodeen in Beijing; Mari Yamaguchi in Tokyo and Hyung-jin Kim in Seoul, South Korea, contributed to this story.


The present invention relates to a method of differentiating mesenchymal stem cells or adult stem cells into nerve cells by treating the mesenchymal stem cells or the adult stem cells with an electromagnetic field having a high intensity of 100 to 1,500 mT and a low frequency of 0.01 to 100 Hz. The present invention also relates to a medical device to which the method is applied. The method of differentiating nerve cells by using a magnetic field, and a composition according to the present invention induce the differentiation of adult stem cells into nerve cells by using a low-frequency, high-intensity electromagnetic field, so that nerve cells or neural stem cells can easily be differentiated through only electromagnetic field treatment in a short time.


The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6, and TNF-alpha induced by macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.


The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, to a production method for same and to a pharmaceutical composition for preventing or treating an inflammatory disease comprising same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6 and TNF-alpha due to macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.


Patent
Dongguk University, Korea Research Institute of Bioscience and Biotechnology | Date: 2016-03-10

The present invention relates to novel compounds as HIF-1 inhibitors, manufacturing process thereof, and a pharmaceutical compositions. The compounds according to the present invention having inhibition activity against HIF-1, can be used as a therapeutic prevention and/or treatment for various solid cancers such as colon cancer, liver cancer, stomach cancer and breast cancer. Also, the compounds according to the present invention are useful in the treatment of diabetic retinopathy and rheumatoid arthritis, which are aggravated by HIF-1-mediated VEGFA expression.

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