Seoul, South Korea
Seoul, South Korea

Dongguk University is a private, coeducational university in South Korea. It operates campuses in Seoul, Gyeongju City, North Gyeongsang province, and Los Angeles, United States. It operates two affiliated hospitals of Western medicine, and four of Oriental medicine, a generic term which includes traditional Korean medicine studies. Wikipedia.


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The present invention relates to a pharmaceutical composition containing a G protein coupled receptor 119 (GPR119) ligand as an active ingredient for preventing or treating non-alcoholic fatty liver disease. More particularly, it was confirmed that the GPR119 ligand, which has been developed as only an anti-diabetic drug, exhibits superior effects on the treatment of non-alcoholic fatty liver and the signal pathways in hepatocytes therefor differ from the signal pathways in the small intestine and the pancreas exhibiting anti-diabetic effects, whereby the GPR119 ligand can be useful to treat non-alcoholic fatty liver.


The present invention relates to a positive electrode active material for a lithium ion battery and, more specifically, to a positive electrode active material for a lithium ion battery, having improved initial capacitance and charging and discharging efficiency due to increased electrical conductivity or ion conductivity. The positive electrode active material for a lithium ion battery of the present invention contains lithium vanadium phosphate (Li_(3)V_(2)(PO_(4))_(3)) and lithium zirconium phosphate (Li_(3)Zr_(2)(PO_(4))_(3)) formed on an external surface of the lithium vanadium phosphate. The positive electrode active material for a lithium ion battery comprising lithium vanadium zirconium phosphate (Li_(3)V_(2-x)Zr_(x)(PO_(4))_(3)) particles, which is prepared by a preparation method of the present invention, has excellent structural stability and ion conductivity as well as high capacitance.


Sarcopenia is an emerging risk factor for metabolic disorders. No study of the association of sarcopenia with insulin resistance, diabetes, and metabolic syndrome (MS) according to age group and obesity status in the general population has been reported. We investigated these associations in the Korean population. Participants included 4558 males and 5874 females, who were ≥20 years of age or older from the fourth and fifth Korea National Health and Nutritional Examination Surveys of the Korean population (2009 and 2010). Age was categorized according to three groups (20-39, 40-59, and ≥ 60 years). Obesity was defined according to body mass index. Sarcopenia was defined as the appendicular skeletal muscle mass (ASM) divided by weight (Wt) (%) of > 2SD below the sex-specific mean for young adults. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. After adjustment for confounding variables, sarcopenia showed a significant association with HOMA-IR in the non-obese group (P<0.001). Sarcopenia was found to be a risk factor for diabetes in the non-obese group (OR, 2.140; 95% CI, 1.549-2.956; P<0.001). Sarcopenia also showed an association with MS in the non-obese group (OR, 2.209; 95% CI, 1.679-2.906; P<0.001), but not in the obesegroup. However, these results were not relevant to young age group. In conclusion, sarcopenia showed an association with insulin resistance, diabetes, and MS, in the non-obese population. Sarcopenia may be an early predictor for diabetes and MS susceptibility in the non-obese population, particularly in elderly people. © The Japan Endocrine Society.


The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6, and TNF-alpha induced by macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.


The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, to a production method for same and to a pharmaceutical composition for preventing or treating an inflammatory disease comprising same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6 and TNF-alpha due to macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.


According to an embodiment of the present disclosure, a multi-acid anionic material-carbon fiber composite comprises carbon nanofibers and multi-acid anionic crystals stuck in the carbon nanofibers. Some of the multi-acid anionic crystals are exposed to an outside of the carbon nanofibers.


Patent
Dongguk University | Date: 2015-09-04

A multi-grid method using a V cycle includes: obtaining a first intermediate solution and a first residual by smoothing a cell of a fine level; obtaining a cell of a coarse level by down-sampling the cell of the fine level and setting the first residual as a second residual of the cell of the coarse level; obtaining a high-frequency component solution of the cell of the fine level and obtaining a smoothed high-frequency component solution by smoothing the high-frequency component solution; obtaining a coarse solution in the cell of the coarse level; up-sampling and transferring the coarse solution to the cell of the fine level and obtaining a corrected intermediate solution by adding the first intermediate solution, the smoothed high-frequency component solution and the coarse solution; and obtaining a second intermediate solution by smoothing the corrected intermediate solution.


Embodiments of the present invention relate to a biodegradable scaffold for replacing tissue or inducing tissue regeneration and a preparation method thereof, wherein the scaffold comprises at least one woven silk tube layer and a collagen layer inside the tube layer. The scaffold is excellent in terms of tissue regeneration and mechanical properties and causes little or no immune response after implantation. Thus, the scaffold can be effectively used as a matrix for the regeneration of ligaments and tendons and the repair of injured muscles.


Patent
Dongguk University | Date: 2015-11-04

Disclosed are a data concealment apparatus and a data concealment method using an Error Correction Code. According to exemplary embodiments of the present invention, it is possible to prevent important information from being easily exposed to a third person by generating encoding data through convolution encoding of input data and thereafter, concealing the encoding data on an image through adjustment of a pixel value on the image and minimize an error which can occur at the time of recovering the input data by extracting the encoding data from the image in a soft decision scheme and performing Viterbi-decoding on the extracted encoding data in order to recover the input data concealed in the image.


Patent
Dongguk University, Korea Research Institute of Bioscience and Biotechnology | Date: 2016-03-10

The present invention relates to novel compounds as HIF-1 inhibitors, manufacturing process thereof, and a pharmaceutical compositions. The compounds according to the present invention having inhibition activity against HIF-1, can be used as a therapeutic prevention and/or treatment for various solid cancers such as colon cancer, liver cancer, stomach cancer and breast cancer. Also, the compounds according to the present invention are useful in the treatment of diabetic retinopathy and rheumatoid arthritis, which are aggravated by HIF-1-mediated VEGFA expression.

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