Seoul, South Korea
Seoul, South Korea

Dongguk University is a private, coeducational university in South Korea. It operates campuses in Seoul, Gyeongju City, North Gyeongsang province, and Los Angeles, United States. It operates two affiliated hospitals of Western medicine, and four of Oriental medicine, a generic term which includes traditional Korean medicine studies. Wikipedia.


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The present invention relates to a pharmaceutical composition containing a G protein coupled receptor 119 (GPR119) ligand as an active ingredient for preventing or treating non-alcoholic fatty liver disease. More particularly, it was confirmed that the GPR119 ligand, which has been developed as only an anti-diabetic drug, exhibits superior effects on the treatment of non-alcoholic fatty liver and the signal pathways in hepatocytes therefor differ from the signal pathways in the small intestine and the pancreas exhibiting anti-diabetic effects, whereby the GPR119 ligand can be useful to treat non-alcoholic fatty liver.


The present invention relates to a positive electrode active material for a lithium ion battery and, more specifically, to a positive electrode active material for a lithium ion battery, having improved initial capacitance and charging and discharging efficiency due to increased electrical conductivity or ion conductivity. The positive electrode active material for a lithium ion battery of the present invention contains lithium vanadium phosphate (Li_(3)V_(2)(PO_(4))_(3)) and lithium zirconium phosphate (Li_(3)Zr_(2)(PO_(4))_(3)) formed on an external surface of the lithium vanadium phosphate. The positive electrode active material for a lithium ion battery comprising lithium vanadium zirconium phosphate (Li_(3)V_(2-x)Zr_(x)(PO_(4))_(3)) particles, which is prepared by a preparation method of the present invention, has excellent structural stability and ion conductivity as well as high capacitance.


Disclosed are 4-substituted-2-(5-substituted-1H-indol-2-yl)phenol derivatives for controlling the proliferation and migration of kinase-overexpressed cells. The phenol derivatives are represented by Formula 1: wherein X is selected from the group consisting of hydrogen, halogen, a cyano group, a trifluoromethyl (CF_(3)) group, an amidine (C(NH)NH_(2)) group, and a 5-methyl-1,2,4-oxadiazole group, Y is selected from the group consisting of hydrogen, halogen, a phenyl group substituted with one or two substituents selected from the group consisting of halogen, methoxy, nitro, trifluoromethyl, and aminomethyl, COR, COOR, OH, OR, and NHR, each R is independently selected from the group consisting of C_(1)-C_(18 )alkyl, alkenyl, alkynyl, and Z-alkyl (wherein Z is a heteroatom selected from the group consisting of O, S, and N or is (CH_(2))_(m)), and m is an integer from 0 to 5. Also disclosed are methods for preparing the phenol derivatives and pharmaceutical compositions for inhibiting cell proliferation and migration including the phenol derivatives. The phenol derivatives and the pharmaceutical compositions can effectively inhibit the proliferation and migration of kinase-overexpressed cells and can be used for the prevention or treatment of various solid cancers and metastatic cancers.


The present invention relates to a carbon nanotube interlayer, a manufacturing method thereof, and a thin film transistor using the same. More specifically, the present invention provides a carbon nanotube interlayer, a manufacturing method thereof, and a thin film transistor using the same, where the carbon nanotube interlayer is a layer constituting an organic thin film transistor and comprising a conjugated polymer and a single-walled carbon nanotube between an organic semiconductor layer and a source/drain electrode. The conjugated polymer selectively wraps the single-walled carbon nanotube having semiconducting properties.


Provided is a pharmaceutical composition for preventing or treating liver fibrosis, comprising a GPR119 ligand as an active ingredient. The composition comprising the GPR119 ligand as an active ingredient significantly inhibits the expression of collagen I, transforming growth factor (TGF) and -smooth muscle actin (-SMA), thereby inhibiting HSC activation, and also significantly inhibits HSC proliferation. Therefore, the composition may be effectively applied in improvement, prevention, inhibition or treatment of liver fibrosis


Patent
Korea Research Institute of Bioscience, Biotechnology and Dongguk University | Date: 2017-03-03

The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6, and TNF-alpha induced by macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.


The present invention relates to a method of differentiating mesenchymal stem cells or adult stem cells into nerve cells by treating the mesenchymal stem cells or the adult stem cells with an electromagnetic field having a high intensity of 100 to 1,500 mT and a low frequency of 0.01 to 100 Hz. The present invention also relates to a medical device to which the method is applied. The method of differentiating nerve cells by using a magnetic field, and a composition according to the present invention induce the differentiation of adult stem cells into nerve cells by using a low-frequency, high-intensity electromagnetic field, so that nerve cells or neural stem cells can easily be differentiated through only electromagnetic field treatment in a short time.


The present invention relates to a method for manufacturing a transistor according selective printing of a dopant. For the manufacture of a transistor, a semiconductor layer is formed on a substrate, and a dopant layer is formed on the semiconductor layer. In the formation of the dopant layer, an inkjet printing is used to selectively print an n type dopant or a p type dopant.


Patent
Dongguk University | Date: 2017-07-19

The present invention relates to a method and kit of detecting a target material using an aptamer, and more particularly to a method and kit for detecting a target material, in which a sample and a second aptamer are added to a first aptamer immobilized on a solid phase so as to form a bond sandwiched between the first aptamer, the target material and the second aptamer, to an FET sensor-based method and kit for detecting a target material, and to an AAO sensor-based method and kit for detecting a target material. The inventive method for a target material using an aptamer can detect even low-molecular-weight materials which were difficult to detect in the prior art, thereby enabling detection of disease-related metabolites, environmental pollutants and food toxins in solutions. In addition, the detection method of the present invention is a direct and simple method and is highly cost-effective, because it uses the aptamer which can be consistently reproduced and can be produced at low costs. Thus, the present invention is very useful.


Patent
Dongguk University | Date: 2016-06-13

The present invention provides a radio frequency identification (RFID)-integrated self-powered time-temperature integrator (TTI), which comprises an RFID and a self-powered TTI which is attached to the exterior of a package of food to output an electric signal indicating a storage state of the food and supplies the electric signal as an operating power of the RFID, in which the electric signal output from the self-powered TTI is a voltage corresponding to a rate of a change in quality of the food accompanied, the quality is calculated by an integration value of time-voltage, and an integration algorithm uses an integrated value, obtained by adding the voltage measured every hour, as a quality variable of the food.

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