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Liu L.-Y.,Tianjin University | Zhou P.-Z.,Dongbei Pharmaceutical Factory | Ning S.-B.,Dongbei Pharmaceutical Factory | Zhang Y.,Dongbei Pharmaceutical Factory | And 2 more authors.
Huaxue Gongcheng/Chemical Engineering (China) | Year: 2012

The separation process of R-(+)-α-phenethylammonium.IR.2S-(-)-cis-1, 2-epoxypropyl phosphonate was investigated. The ordinary unloading centrifuges in use have many problems, such as the low efficiency in the filtration separation, the high difficulty in the unloading of filter cake. To solve these problems, firstly, ethanol was added to decrease the liquid viscosity, which can improve the performance of the filtration separation, then a shaking bag centrifuge was chosen as a new centrifuge with the liquid skimming system, and the industrial tests were performed. The tests results show that, compared with the ordinary unloading centrifuge, the shaking bag centrifuge obviously exhibits the advantages of good seal, little residual filter cake, short unloading time, big unloading capacity, and higher production efficiency. These results not only provide some references for the choice of the centrifuge in the production but also lay the foundation for enhancing the production efficiency and improving the work environment in the subsequent production.

Qiao L.,Tianjin University | Tan W.,Tianjin University | Cui B.,Dongbei Pharmaceutical Factory | Liu Y.,Dongbei Pharmaceutical Factory | And 2 more authors.
Huaxue Gongcheng/Chemical Engineering (China) | Year: 2011

The mother liquor components and viscosity of R-(+)-α-phenethylammonium. IR.2S-(-)-cis-1,2-epoxypropyl phosphonate were analyzed on the basis of the liquid mixtures viscosity theory. With the proper viscosity equations, the theoretical calculation formula of mother liquor viscosity of R-(+)-α-phenethylammonium.IR.2S-(-)-cis-1, 2-epoxypropyl phosphonate with ethanol or water was obtained. The calculated viscosity was compared with the experimental results. It shows that the theoretical viscosity calculation formula is well correlated with the systems containing a little water, but has some deviation with the system containing more water. The result also reveals that ethanol and a certain amount of water can efficiently reduce the viscosity of mother liquor, which supplies a simple and convenient way for engineering application in the chemical production of fosfomycin sodium.

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