For other colleges with the same name, see Dominican CollegeDominican University of California is a 2,200-student institution in San Rafael, California.Founded in 1890 as Dominican College, Dominican is one of the oldest universities in California. Wikipedia.
Wallace L.R.,Dominican University of California
International Nursing Review | Year: 2015
Purpose/Aim: To describe an intercollaborative outreach between the USA and a school of nursing in Uganda. Introduction: Ugandan nurses are essential providers of health care in remote regions. High vacancy rates in health centers impacts care in rural areas. Background: A 112-bed health center in southwest Uganda supports village health teams that visit remote villages and provides medical, surgical, and maternal-child services to a population of 250,000. A new Ugandan school of nursing has aligned with the hospital to prepare graduates to provide primary care in remote villages. A team from the USA visited the school and hospital to assess the curriculum and offer educational strategies and support to the school's leadership. Evidence: Provision of primary health care in the developing world is a longstanding global priority. Nurses are at the center of primary care in remote regions. Educational support for advanced nursing and strategic international relationships can positively impact nursing education in both high and low-income countries. Discussion: The USA team took part in assessments, teaching, simulation, and remote village outreach. Educational strategies and modalities were shared. Conclusions: The Ugandan nursing school is established and affiliated with another Ugandan university. Standardized curriculum is in place, however continued collaboration is needed for program adaptation to accommodate the unique border region environment. Implications for Health Policy and Nursing: Intercollaborative sharing of information and resources between schools of nursing can have a direct impact on global health initiatives in both high-income and low-income countries. International Nursing Review © 2015 International Council of Nurses. Source
Folse H.J.,Archimedes Inc |
Green L.E.,Dominican University of California |
Kress A.,Archimedes Inc |
Allman R.,Genetic Technologies |
Dinh T.A.,Archimedes Inc
Cancer Prevention Research | Year: 2013
Genetic testing of seven single-nucleotide polymorphisms (7SNP) can improve estimates of risk of breast cancer relative to the Gail risk test alone, for the purpose of recommending MRI screening for women at high risk. A simulation of breast cancer and health care processes was used to conduct a virtual trial comparing the use of the 7SNP test with the Gail risk test to categorize patients by risk. Average-risk patients received annual mammogram, whereas high-risk patients received annual MRI. Cancer incidence was based on Surveillance, Epidemiology, and End Results data and validated to Cancer Prevention Study II Nutrition Cohort data. Risk factor values were drawn from National Health and Nutrition Examination Survey (NHANES-4) and Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial data. Mammogram characteristics were derived from Breast Cancer Surveillance Consortium data. The test was most cost-effective when given to patients at an intermediate lifetime risk of breast cancer. For patients with a risk of 16% to 28%, it resulted in a 1.91% reduction in cancer deaths, saving 0.005 quality-adjusted life years per person at a cost of $163,264 per QALY. These results were sensitive to the age at which the test is given, the discount rate, and the costs of the genetic test and MRI. The cost effectiveness of using the 7SNP test for patients with intermediate Gail risk is similar to that of other recommended strategies, including annual MRI for patients with a lifetime risk greater than 20% or BRCA1/2 mutations. ©2013 AACR. Source
El Majdoubi M.,Dominican University of California
Journal of Toxicology and Environmental Health - Part B: Critical Reviews | Year: 2011
Neuroendocrine cells are a set of specialized hormone-releasing neurons that control most vital functions in humans and wildlife, such as growth, reproduction, metabolism, and stress responses. Increasing evidence points to neuroendocrine cells as the primary neuronal target of endocrine disruptors. Endocrine disruption appears to be most significant during prenatal and early postnatal development. However, limitations with traditional cell culture models of neuronal development led to a lack of understanding regarding the mechanisms by which endocrine disruptors affect neurodevelopment. In recent years, Stem Cell-derived neuronal models have become available and may offer distinct advantages over other in vitro model systems for investigating the effects of endocrine disruptors on the developing brain. Further, recently new models of Stem Cell-derived neuroendocrine cells that may provide more effective ways for studying the effects of endocrine disruptors directly on developing neuroendocrine cells in vitro were developed. This constitutes a review of currently available cell models of developing neurons that have been used to investigate in vitro effects of endocrine disruptors on developing brain. The review also presents recently developed models of Stem Cell-derived neuroendocrine cells that might be used to investigate in vitro effects of endocrine disruptors and their mechanisms of action directly on the developing neuroendocrine cells. Copyright © Taylor & Francis Group, LLC. Source
Noah-Vanhoucke J.,Archimedes Inc |
Green L.E.,Archimedes Inc |
Green L.E.,Dominican University of California |
Dinh T.A.,Archimedes Inc |
And 2 more authors.
Cancer | Year: 2011
BACKGROUND: Previous cost-effectiveness analyses of tamoxifen therapy account for breast cancer risk reduction during active treatment but not for its persistent protective effect after active treatment. METHODS: A detailed, continuous time, mathematical model of breast cancer and healthcare processes was used to simulate a postmenopausal population aged <55 years in a virtual trial comparing tamoxifen treatment with no treatment for lifetime follow-up. Unlike previous work, the current model of tamoxifen therapy is based on a meta-analysis of 4 randomized, placebo-controlled chemoprevention trials with breast cancer risk reduction continuing for 10 years after treatment termination. Cancer incidence and survival data were derived from Surveillance, Epidemiology and End Results statistics. Noncancer disease incidences, quality-adjusted life year (QALY) utility weights, and costs were derived from the literature. RESULTS: Tamoxifen treatment (vs no treatment) saved 29 QALYs in a population of 1000 postmenopausal women aged <55 years with an additional cost of $333,000 over the population's lifetime (average cost-effectiveness ratio, $11,530 per QALY). Tamoxifen therapy, compared with no treatment, was cost saving when higher risk populations were targeted (5-year risk ≥1.66%). The cost-effectiveness results were sensitive to parameters that characterized menopausal symptoms and adverse side effects of tamoxifen. CONCLUSIONS: The current results indicated that tamoxifen chemoprophylaxis for postmenopausal women aged <55 years is a cost-effective health policy that reduces breast cancer incidence and improves life expectancy. Focusing on a postmenopausal population aged <55 years minimized the threat of adverse events associated with tamoxifen. © 2011 American Cancer Society. Source
Agency: NSF | Branch: Standard Grant | Program: | Phase: | Award Amount: 66.80K | Year: 2010
Recent advances in molecular biology and biotechnology have opened up new opportunities in cell biology, biochemistry, and genomics. This Major Research Instrumentation award funds the acquisition of a molecular imager to support biology and biotechnology research at Dominican University of California. The new equipment will enable Dominican University faculty to advance their own active research programs and allow the University to better integrate education and research to train the next generation of scientists. The molecular imager will support undergraduate training in six research laboratories that represent a wide range of biological research. Dr. Louie is examining mechanisms of cadmium and nickel induced gene regulation in mammalian cells to correlate expression analysis to growth, development and homeostasis. Dr. Ghosh is studying how arsenic affects gene expression in different rice cultivars. Additional projects include research on pollen germination, neuroendocrine development, and COX-2 physiology. In total, these projects will impact 35-45 students/year, and the results of these research and teaching efforts will be broadly disseminated through abstracts and peer reviewed publications, as well as by active participation of students and faculty at professional meetings.