Dominican University is a coeducational, comprehensive, Catholic institution of higher education and research in River Forest, Illinois. Affiliated with the Sinsinawa Dominican Sisters, it offers bachelor's and master's degrees and certificate programs as well as a PhD in library and information science. Dominican offers more than 50 majors in the Rosary College of Arts and science and 20 programs in five graduate academic divisions offering graduate programs in library and information science, business, the School of Education, and social work. Dominican also has a School of Professional and Continuing Studies. Dominican is well known for its offerings of undergraduate programs in the arts and science as well as several graduate programs in practice-oriented disciplines such as business and education. US News and World Report ranks Dominican in the top tier of Midwestern master's-level universities. Wikipedia.
Gregory F.D.,University of Iowa |
Gregory F.D.,Emory University |
Bryan K.E.,University of Iowa |
Pangrsic T.,Center for Molecular Physiology of the Brain |
And 4 more authors.
Nature Neuroscience | Year: 2011
Harmonin is a scaffolding protein that is required for normal mechanosensory function in hair cells. We found a presynaptic association of harmonin and Cav 1.3 Ca2+ channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway. © 2011 Nature America, Inc. All rights reserved.
Lysakowski A.,University of Illinois at Chicago |
Gaboyard-Niay S.,French Institute of Health and Medical Research |
Calin-Jageman I.,Dominican University at River Forest |
Chatlani S.,University of Chicago |
And 3 more authors.
Journal of Neuroscience | Year: 2011
Many primary vestibular afferents form large cup-shaped postsynaptic terminals (calyces) that envelope the basolateral surfaces of type I hair cells. The calyceal terminals both respond to glutamate released from ribbon synapses in the type I cells and initiate spikes that propagate to the afferent's central terminals in the brainstem. The combination of synaptic and spike initiation functions in these unique sensory endings distinguishes them from the axonal nodes of central neurons and peripheral nerves, such as the sciatic nerve, which have provided most of our information about nodal specializations.Weshow that rat vestibular calyces express an unusual mix of voltage-gatedNa and K channels and scaffolding, cell adhesion, and extracellular matrix proteins, which may hold the ion channels in place. Protein expression patterns form several microdomains within the calyx membrane: a synaptic domain facing the hair cell, the heminode abutting the first myelinated internode, and one or two intermediate domains. Differences in the expression and localization of proteins between afferent types and zones may contribute to known variations in afferent physiology. © 2011 the authors.
Kowalczyk S.T.,Dominican University at River Forest
Proceedings of the ACM/IEEE Joint Conference on Digital Libraries | Year: 2015
This paper describes the results of a large survey designed to quantify the risks and threats to the preservation of the research data in the lab and to determine the mitigating actions of researchers. A total of 724 National Science Foundation awardees completed this survey. Identifying risks and threats to digital preservation has been a significant research stream. Much of this work has been within the context of a preservation technology infrastructure such as data archives for a digital repository. This study looks at the risks and threats to research data prior to its inclusion in a preservation technology infrastructure. The greatest threat to preservation is human error, followed by equipment malfunction, obsolete software, and data corruption. Lost and mislabeled media are not components in the threat taxonomies developed for repositories; however, they do represent an important threat to research data in the lab. Researchers have recognized the need to mitigate the risks inherent in maintaining digital data by implementing data management in their lab environments and have taken their responsibility as data managers seriously; however, they would still prefer to have professional data management support. © 2015 ACM.
Friesen J.B.,Dominican University at River Forest |
Friesen J.B.,University of Illinois at Chicago |
Ahmed S.,Dominican University at River Forest |
Pauli G.F.,University of Illinois at Chicago
Journal of Chromatography A | Year: 2015
Rational solvent system selection for countercurrent chromatography and centrifugal partition chromatography technology (collectively known as countercurrent separation) studies continues to be a scientific challenge as the fundamental questions of comparing polarity range and selectivity within a solvent system family and between putative orthogonal solvent systems remain unanswered. The current emphasis on metabolomic investigations and analysis of complex mixtures necessitates the use of successive orthogonal countercurrent separation (CS) steps as part of complex fractionation protocols. Addressing the broad range of metabolite polarities demands development of new CS solvent systems with appropriate composition, polarity (π), selectivity (σ), and suitability. In this study, a mixture of twenty commercially available natural products, called the GUESSmix, was utilized to evaluate both solvent system polarity and selectively characteristics. Comparisons of GUESSmix analyte partition coefficient (K) values give rise to a measure of solvent system polarity range called the GUESSmix polarity index (GUPI). Solvatochromic dye and electrical permittivity measurements were also evaluated in quantitatively assessing solvent system polarity. The relative selectivity of solvent systems were evaluated with the GUESSmix by calculating the pairwise resolution (αip), the number of analytes found in the sweet spot (Nsw), and the pairwise resolution of those sweet spot analytes (αsw). The combination of these parameters allowed for both intra- and inter-family comparison of solvent system selectivity. Finally, 2-dimensional reciprocal shifted symmetry plots (ReSS2) were created to visually compare both the polarities and selectivities of solvent system pairs. This study helps to pave the way to the development of new solvent systems that are amenable to successive orthogonal CS protocols employed in metabolomic studies. © 2014 Elsevier B.V.
Zak E.,Dominican University at River Forest
Information Technology and Libraries | Year: 2014
Augmented reality (AR) technology has implications for the ways that the field of library and information science (LIS) serves users and organizes information. Through content analysis, the author examined how AR is conceptualized within a sample of LIS literature from the Library, Information Science and Technology Abstracts (LISTA) database and Google Blogs postings. The author also examined whether Radical Change Theory (RCT) and the digital]age principles of interactivity, connectivity, and access are present in the discussion of this technology. The analysis of data led to the identification of 14 categories comprising 132 total codes across sources within the data set. The analysis indicates that the conceptualization of AR, while inconsistent, suggests expectations that the technology will enhance the user experience. This can lead to future examinations of user behavior, response, and observation of technologies like AR.
Domin D.,Dominican University at River Forest |
Bodner G.,Purdue University
Journal of Chemical Education | Year: 2012
The differences in the types of representations constructed during successful and unsuccessful problem-solving episodes were investigated within the context of graduate students working on problems that involve concepts from 2D-NMR. Success at problem solving was established by having the participants solve five problems relating to material just encountered within a computer-based tutorial. The results indicate that representations constructed during successful problem-solving episodes tend to be more accurate and more complete, but not as abstract as those constructed during unsuccessful problem-solving episodes. When more than a single representation was constructed, however, the additional representations associated with successful problem solving tended to be more abstract than those constructed during unsuccessful problem solving. The authors contend that the constructs of accuracy, abstractness, and completeness are useful for characterizing the differences in the representations constructed during successful and unsuccessful problem-solving episodes, and may serve as useful indicators of the degree of conceptual understanding the individual brings to the problem-solving event. © 2012 The American Chemical Society and Division of Chemical Education, Inc.
Beto J.,Dominican University at River Forest
Nephrology nursing journal : journal of the American Nephrology Nurses' Association | Year: 2010
Early mortality is a significant concern for patients initiating dialysis. Nutrition and exercise are two factors that affect mortality rates that can be significantly influenced by a successful partnership between the healthcare team and the patient. This article provides an overview of current data on the importance of appropriate nutritional and exercise regimens for patients initiating dialysis, as well as tips for how nurses and other members of the healthcare team can work to incrementally improve these components of care.
Weedermann M.,Dominican University at River Forest
Mathematical Biosciences and Engineering | Year: 2012
Anaerobic digestion has been modeled as a two-stage process using coupled chemostat models with non-monotone growth functions, . This study incorporates the effects of an external toxin. After reducing the model to a 3-dimensional system, global stability of boundary and interior equilibria is proved using differential inequalities and comparisons to the corresponding toxin-free model. Conditions are given under which the behavior of the toxinfree model is preserved. Introduction of the toxin results in additional patterns such as bistabilities of coexistence steady states or of a periodic orbit and an interior steady state.
Gregory F.D.,University of Iowa |
Pangrsic T.,University of Gottingen |
Calin-Jageman I.E.,Dominican University at River Forest |
Moser T.,University of Gottingen |
Lee A.,University of Iowa
Journal of Physiology | Year: 2013
Cav1.3 channels mediate Ca2+ influx that triggers exocytosis of glutamate at cochlear inner hair cell (IHC) synapses. Harmonin is a PDZ-domain-containing protein that interacts with the C-terminus of the Cav1.3 α1 subunit (α11.3) and controls cell surface Cav1.3 levels by promoting ubiquitin-dependent proteosomal degradation. However, PDZ-domain-containing proteins have diverse functions and regulate other Cav1.3 properties, which could collectively influence presynaptic transmitter release. Here, we report that harmonin binding to the α11.3 distal C-terminus (dCT) enhances voltage-dependent facilitation (VDF) of Cav1.3 currents both in transfected HEK293T cells and in mouse inner hair cells. In HEK293T cells, this effect of harmonin was greater for Cav1.3 channels containing the auxiliary Cavβ1 than with the β2 auxiliary subunit. Cav1.3 channels lacking the α11.3 dCT were insensitive to harmonin modulation. Moreover, the 'deaf-circler'dfcr mutant form of harmonin, which does not interact with the α11.3 dCT, did not promote VDF. In mature IHCs from mice expressing the dfcr harmonin mutant, Cav1.3 VDF was less than in control IHCs. This difference was not observed between control and dfcr IHCs prior to hearing onset. Membrane capacitance recordings from dfcr IHCs revealed a role for harmonin in synchronous exocytosis and in increasing the efficiency of Ca2+ influx for triggering exocytosis. Collectively, our results indicate a multifaceted presynaptic role of harmonin in IHCs in regulating Cav1.3 Ca2+ channels and exocytosis. © 2013 The Authors. The Journal of Physiology © 2013 The Physiological Society.
Wilson-Edell K.A.,Buck Institute for Research on Aging |
Yevtushenko M.A.,Buck Institute for Research on Aging |
Yevtushenko M.A.,Dominican University at River Forest |
Rothschild D.E.,Buck Institute for Research on Aging |
And 2 more authors.
Breast Cancer Research and Treatment | Year: 2014
Resistance of breast cancers to targeted hormone receptor (HR) or human epidermal growth factor receptor 2 (HER2) inhibitors often occurs through dysregulation of the phosphoinositide 3-kinase, protein kinase B/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway. Presently, no targeted therapies exist for breast cancers lacking HR and HER2 overexpression, many of which also exhibit PI3K/AKT/mTOR hyper-activation. Resistance of breast cancers to current therapeutics also results, in part, from aberrant epigenetic modifications including protein acetylation regulated by histone deacetylases (HDACs). We show that the investigational drug MLN0128, which inhibits both complexes of mTOR (mTORC1 and mTORC2), and the hydroxamic acid pan-HDAC inhibitor TSA synergistically inhibit the viability of a phenotypically diverse panel of five breast cancer cell lines (HR-/+, HER2-/+). The combination of MLN0128 and TSA induces apoptosis in most breast cancer cell lines tested, but not in the non-malignant MCF-10A mammary epithelial cells. In parallel, the MLN0128/TSA combination reduces phosphorylation of AKT at S473 more than single agents alone and more so in the 5 malignant breast cancer cell lines than in the non-malignant mammary epithelial cells. Examining polysome profiles from one of the most sensitive breast cancer cell lines (SKBR3), we demonstrate that this MLN0128/TSA treatment combination synergistically impairs polysome assembly in conjunction with enhanced inhibition of 4eBP1 phosphorylation at S65. Taken together, these data indicate that the synergistic growth inhibiting consequence of combining a mTORC1/C2 inhibitor like MLN0128 with a pan-HDAC inhibitor like TSA results from their mechanistic convergence onto the PI3K/AKT/mTOR pathway, profoundly inhibiting both AKT S473 and 4eBP1 S65 phosphorylation, reducing polysome formation and cancer cell viability. © 2014 Springer Science+Business Media.