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Patent
California Institute of Technology, University of Southern California and Doheny Eye Institute | Date: 2016-09-09

An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.


Patent
Doheny Eye Institute | Date: 2016-08-26

In accordance with one aspect of the present invention, an optical coherence tomography instrument comprises an eyepiece for receiving at least one eye of a user is provided; a light source that outputs light that is directed through the eyepiece into the users eye; an interferometer configured to produce optical interference using light reflected from the users eye; an optical detector disposed so as to detect said optical interference; and electronics coupled to the detector. The electronics can be configured to perform a risk assessment analysis based on optical coherence tomography measurements obtained using the interferometer. An output device can be electrically coupled to the electronics, and may be configured to output the risk assessment to the user through the output device. The optical coherence tomography instrument can be self-administered, and the eyepiece can be a monocular system or a binocular system.


Patent
Doheny Eye Institute | Date: 2016-10-03

A surgical apparatus for use by a surgeon can include a tray and a plurality of surgical instruments. The tray can have a plurality of structures located on an upper side of the tray for receiving the plurality of surgical instruments. The tray can receive a separate control unit. The tray can also have a fluid reservoir receiver for receiving a bottle or container of fluid, such as balanced salt solution. The fluid reservoir receiver can include one or more features, including, a spike, an air vent, and a light. A separate container can be used to place the bottle or container of fluid into the fluid reservoir receiver on the tray. This separate container can include a collapsible section.


Patent
Doheny Eye Institute | Date: 2017-04-05

Surgical systems including a surgical tray unit including a portable surgical tray for housing a processing unit, a plurality of instruments connected to the portable surgical tray and operably coupled to the processing unit. A user input device positioned on at least one of the plurality of instruments. The user input device is operably coupled to the processing unit. The user input device is configured to receive a user input for controlling an operating parameter of one or more of the plurality of instruments. The processing unit is configured to receive user input through the user input device and transmit an operating command to the one or more of the plurality of instruments. The portable surgical tray and the plurality of instruments are sterilized and prepackaged in a single package.


Patent
Doheny Eye Institute | Date: 2017-04-19

There is provided a handheld surgical instrument comprising: a distal end for performing a surgical function; a body portion connected to the distal end and forming a housing; a processor contained within the housing; user controls formed on the housing and connected to the processor. The processor and user controls control the surgical function of the handheld surgical instrument and control a function of at least one other device associated with a surgery being performed. A surgical tray is also provided.


Hwang J.C.,Doheny Eye Institute
Investigative ophthalmology & visual science | Year: 2012

To determine the relationship among visual field, neural structural, and blood flow measurements in glaucoma. Case-control study. Forty-seven eyes of 42 patients with perimetric glaucoma were age-matched with 27 normal eyes of 27 patients. All patients underwent Doppler Fourier-domain optical coherence tomography to measure retinal blood flow and standard glaucoma evaluation with visual field testing and quantitative structural imaging. Linear regression analysis was performed to analyze the relationship among visual field, blood flow, and structure, after all variables were converted to logarithmic decibel scale. Retinal blood flow was reduced in glaucoma eyes compared to normal eyes (P < 0.001). Visual field loss was correlated with both reduced retinal blood flow and structural loss of rim area and retinal nerve fiber layer (RNFL). There was no correlation or paradoxical correlation between blood flow and structure. Multivariate regression analysis revealed that reduced blood flow and structural loss are independent predictors of visual field loss. Each dB decrease in blood flow was associated with at least 1.62 dB loss in mean deviation (P ≤ 0.001), whereas each dB decrease in rim area and RNFL was associated with 1.15 dB and 2.56 dB loss in mean deviation, respectively (P ≤ 0.03). There is a close link between reduced retinal blood flow and visual field loss in glaucoma that is largely independent of structural loss. Further studies are needed to elucidate the causes of the vascular dysfunction and potential avenues for therapeutic intervention. Blood flow measurement may be useful as an independent assessment of glaucoma severity.


Hwang J.C.,Doheny Eye Institute
American Journal of Ophthalmology | Year: 2012

Purpose: To determine if there are variations in regional practice patterns for retinal detachment repair in the United States. Design: Retrospective, noninterventional, cross-sectional study. Methods: Year 2009 Medicare fee-for-service claims for retinal detachment repair were aggregated in 4 geographic regions and evaluated. The relative preference for retinal detachment repair by pars plana vitrectomy, scleral buckling, and pneumatic retinopexy was analyzed. Results: The Midwest demonstrated a greater preference for scleral buckling compared to all other regions (P <.01) and lower preference for pars plana vitrectomy relative to the South and West (P ≤.02). The Northeast demonstrated a greater preference for pneumatic retinopexy when compared to all other regions (P <.01). The Northeast also revealed a trend toward a lower preference for pars plana vitrectomy compared to the West and South (P ≤.08). Conclusion: There are statistically significant variations in regional practice patterns for retinal detachment repair. The West, despite its historical association with pneumatic retinopexy, did not demonstrate a greater preference for the surgical technique. © 2012 Elsevier Inc. All rights reserved.


Patent
University of Southern California and Doheny Eye Institute | Date: 2016-01-22

Disclosed herein are generally to methods and systems that facilitate imaging of cells on a substrate and more particularly to pre-implantation (in vitro) and post-implantation (in vivo) imaging of cell-seeded substrates implanted in target tissues in the context of stem cell therapy.


Patent
Doheny Eye Institute | Date: 2016-08-10

An optical coherence tomography instrument is disclosed. The instrument comprises an eyepiece for receiving at least one eye of a user, at least one target display visible through said eyepiece, and a light source that outputs light that is directed through the eyepiece to the users eye. The instrument further comprises an interferometer configured to produce optical interference using light reflected from the users eye, an optical detector disposed so as to detect said optical interference, and electronics coupled to the target display and said detector. The electronics are configured to provide an output based on optical coherence tomography measurements obtained using said interferometer, and to produce features on said target display of varying size and receive user responses to test a users visual acuity.


Patent
Doheny Eye Institute | Date: 2015-10-28

A sterile surgical tray (10) includes structure (12) for receiving a plurality of surgical instruments (14), a pump fluid reservoir (30) within the tray (10), a pump (40) contained within the sterile tray (30) and connected to the pump fluid reservoir (30), and a motor (42) contained within the sterile tray and connected to the pump (40). Sterile surgical tray (10) also may include electrical input and output connectors attached to tray (10).

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