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Hospital de Órbigo, Spain

Lahera G.,University of Alcala | Herrera S.,Doce Of Octubre University Hospital | Reinares M.,University of Barcelona | Benito A.,Provincial Hospital of Toledo | And 3 more authors.
Acta Psychiatrica Scandinavica | Year: 2015

Objective: To compare the profile of attributional style of a group of out-patients with bipolar disorder (BD) and schizophrenia (SZ), and a group of healthy controls - along with other social cognition domains - such as emotion recognition and theory of mind (ToM). Method: A total of 46 out-patients diagnosed with BD, 49 with SZ, and 50 healthy controls were assessed in attributional style (Ambiguous Intentions Hostility Questionnaire), facial emotion recognition (FEIT, FEDT, ER-40), and ToM (Hinting Task). Symptomatology, clinical variables and global functioning were also collected. Results: Both groups with SZ and BD showed hostile social cognitive biases, compared with the control group. Patients with BD also showed a capacity for emotional recognition similar to those with SZ and worse than control subjects. In contrast, patients with SZ showed poorer ToM. Subthreshold depressive symptoms and an attributional style toward hostility appeared as the factors with a strongest association to global functioning in BD. In SZ, PANSS score and a tendency to aggressiveness were the most relevant factors. Conclusion: Attributional style (along with other domains of social cognition) is altered in out-patients with BD and SZ. The presence of residual symptoms and a hostile social cognitive bias may contribute to the functional impairment of both groups. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

De Dosso S.,Oncology Institute of Southern Switzerland | Grande E.,Ramon y Cajal University Hospital | Barriuso J.,Hospital Universitario La Paz | Castellano D.,Doce Of Octubre University Hospital | And 2 more authors.
Cancer and Metastasis Reviews | Year: 2013

The molecular events of tumorigenesis in neuroendocrine tumors are poorly understood. Understanding of the molecular alterations will lead to the identification of molecular markers, providing new targets for therapeutics. The purpose of this review was to critically analyze the genetic abnormalities in neuroendocrine tumors, with the aim of identifying biomarkers that indicate a response to agents developed against these targets and to serve as an understanding for the combinations of different active compounds. Human epidermal growth factor receptor 1/2 (EGFR and HER2), vascular endothelial growth factor receptors, hepatocyte growth factor receptor (c-Met), platelet-derived growth factor receptor, insulin-like growth factor, phosphatidylinositol 3-kinase-Akt-mammalian target of rapamycin pathway, and heat shock proteins are all interesting candidate biomarkers with involvement in carcinogenesis and tumor evolution of several neoplasms, including neuroendocrine tumors. Some of them have already been evaluated both as targets and also as biomarkers in clinical trials conducted in advanced neuroendocrine tumor settings, and others should encourage further investigations into innovative therapeutic opportunities. © 2013 Springer Science+Business Media New York.

Maynar Moliner J.,University of Santiago de Compostela | Honore P.M.,Vrije Universiteit Brussel | Sanchez-Izquierdo Riera J.A.,Doce Of Octubre University Hospital | Herrera Gutierrez M.,University of Malaga | Spapen H.D.,Vrije Universiteit Brussel
Blood Purification | Year: 2012

Continuous renal replacement therapy (CRRT) is increasingly used for the management of critically ill patients. As a consequence, the incidence of complications that accompany CRRT is also rising. However, a standardized approach for preventing or minimizing these adverse events is lacking. Dialytrauma is a newly proposed concept that encompasses all harmful adverse events related to CRRT while providing a framework for prevention or, at the least, early recognition of these events in order to attenuate the consequences. A mainstay of this approach is the utilization of a dedicated checklist for improving CRRT quality and patient safety. In this context, we discuss the most important adverse effects of CRRT and review current strategies to minimize them. Copyright © 2012 S. Karger AG, Basel.

Bravo F.G.,Complutense University of Madrid | Bravo F.G.,Doce Of Octubre University Hospital | Kufeke M.,Octubre University Hospital | Pascual D.,Gregorio Maranon University Hospital
Aesthetic Surgery Journal | Year: 2013

Background: To avoid complications and improve patient satisfaction with lower lid blepharoplasty, a precise assessment of any preoperative eyelid asymmetry is essential. Objectives: The authors describe a method of assessing preoperative eyelid asymmetry through readily available software and classifying the resulting measurements. Methods: Digital images of 204 patients were analyzed using Photoshop CS3 Extended software (Adobe Systems, San Jose, California). The left eye was superimposed over the right eye using layers in the software program, and the lower eyelid margin and axis were outlined to obtain a diagram with the superimposed outlines of both eyes. Several measurements (ie, lateral canthal height, lower eyelid margin length and axis angle, and lower palpebral fissure surface area) were obtained for each patient. Differences between the right and left eyelids were recorded, and these data were compared between patients. Results: Of the 204 patients studied, 184 (90.2%) had some degree of asymmetry. Most (118; 64.13%) presented with the right lower eyelid at a more inferior position than the left (R-), while 66 (35.87%) presented with the right lower eyelid at a higher position than the left (R+), a difference that was highly significant (P < .001). Conclusions: This software is a powerful and precise tool to evaluate and measure eyelid asymmetries. The use of this method showed a large degree of eyelid asymmetry preoperatively (more than 90%), which proves the importance of detecting and adequately analyzing this condition prior to surgery. The authors? simple method may be an important adjunct to obtaining optimal results in patients who seek eyelid surgery. © 2013 The American Society for Aesthetic Plastic Surgery, Inc.

Lafosse A.,Catholic University of Louvain | De Magnee C.,Catholic University of Louvain | Brunati A.,Catholic University of Louvain | Bayet B.,Catholic University of Louvain | And 3 more authors.
Pediatric Transplantation | Year: 2012

We report the case of a two and a half yr boy hospitalized in our Pediatric Transplantation Unit for portal vein thrombosis following liver transplantation. After performing a meso-Rex shunt, abdominal wall closure was impossible without compressing the portal flow. A combination of two techniques was used to perform the reconstruction of the muscular fasciae and skin layers. The association of tissue expanders and porcine mesh (Surgisis®) allowed complete abdominal wall closure with good functional and esthetic results. Use of both techniques is a useful alternative for difficult abdominal closure after liver pediatric transplantation. © 2011 John Wiley & Sons A/S.

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