Doaba College

Jalandhar, India

Doaba College

Jalandhar, India
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Gill B.S.,Central University of Punjab | Kumar S.,Central University of Punjab | Navgeet,Doaba College
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | Year: 2017

Lung cancer causes huge mortality worldwide, and targeting new pathway may provide an alternative in modulating signaling in cancer. Nuclear factor erythroid 2-related factor 2 is the major regulator of endogenous and exogenous stress by activating numerous antioxidant genes critical in cancer, Alzheimer's, Parkinson's, and inflammatory bowel diseases. Ganoderic acid is a triterpene from basiodiomycetes fungus Ganoderma lucidum with numerous therapeutic effects. In this study, ganoderic acid and its 50 isomers and natural activators were docked by receptor-based molecular docking using Maestro 9.6 (Schrödinger Inc.) in the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 signaling pathway. The receptor-based molecular docking reveals the best binding interaction of nuclear factor erythroid 2-related factor 2 and ganoderic acid A with GScore (-9.69) (kcal/mol), Lipophilic EvdW (-1.83), Electro (-0.72), Glide emodel (-73.369), H bond (-1.1), molecular mechanics/generalized Born surface area (-75.541) with Leu 718, Asp 800, Cys 797 residues involved in hydrogen bonding. The calculated docking energy highlights the lipophilic, hydrogen bonding, pi-pi stacking interactions, and non-covalent bonding. Analysis showed the involvement of cysteine and serine residues which were crucial in the activation and translocation from cytoplasm to the nucleus in the nuclear factor erythroid 2-related factor 2 signaling process. The molecular docking tool QikProp analyzed the absorption, distribution, metabolism, excretion, and toxicity but needs some modifications in their structure to satisfy Lipinski's rule. Ganoderic acid A is a best docked isoform which inhibits the cell proliferation, viability, migration, and reactive oxygen species and messenger RNA expression of nuclear factor erythroid 2-related factor 2 in H460 cells.


Gill B.S.,Central University of Punjab | Navgeet,Doaba College | Kumar S.,Central University of Punjab
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | Year: 2017

Lung cancer causes huge mortality to population, and pharmaceutical companies require new drugs as an alternative either synthetic or natural targeting lung cancer. The conventional therapies cause side effects, and therefore, natural products are used as a therapeutic candidate in lung cancer. Chemical diversity among natural products highlights the impact of evolution and survival of fittest. One such neglected natural product is Ganoderma lucidum used for promoting health and longevity for a longer time. The major bioconstituents of G. lucidum are mainly terpenes, polysaccharides, and proteins, which were explored for various activities ranging from apoptosis to autophagy. The bioconstituents of G. lucidum activate plasma membrane receptors and initiate various downstream signaling leading to nuclear factor-κB, phosphoinositide 3-kinase, Akt, and mammalian target of rapamycin in cancer. The bioconstituents regulate the expression of various genes involved in cell cycle, immune response, apoptosis, and autophagy in lung cancer. This review highlights the inextricable role of G. lucidum and its bioconstituents in lung cancer signaling for the first time.


Jayoti D.,National Institute of Technology Jalandhar | Malik P.,National Institute of Technology Jalandhar | Singh A.,Doaba College
AIP Conference Proceedings | Year: 2016

Citrate buffer stabilized gold nano particles (GNPs) were doped into a ferroelectric liquid crystal (FLC). Dielectric relaxation spectroscopy was carried out in the range 20Hz-10MHz. The behavior of permittivity was analyzed as a function of frequency and temperature. It was observed that adding a small amount of GNPs, the permittivity changes significantly by almost three times as compared to the pure FLC. Goldstone mode of relaxation was observed both in pristine and GNPs doped FLC. The relaxation frequency of this mode shifted to 80Hz and in case of pristine FLC, the frequency was observed to be 250Hz. © 2016 Author(s).


Bhandari P.,Doaba College | Gujral M.S.,Punjabi University
2014 Recent Advances in Engineering and Computational Sciences, RAECS 2014 | Year: 2014

This paper presents an ontological approach to perceive the current security status of the network. Computer network is a dynamic entity whose state changes with the introduction of new services, installation of new network operating system, and addition of new hardware components, creation of new user roles and by attacks from various actors instigated by aggressors. Various security mechanisms employed in the network does not give the complete picture of security of complete network. In this paper we have proposed taxonomy and ontology which may be used to infer impact of various events happening in the network on security status of the network. Vulnerability, Network and Attack are the main taxonomy classes in the ontology. Vulnerability class describes various types of vulnerabilities in the network which may in hardware components like storage devices, computing devices or networks devices. Attack class has many subclasses like Actor class which is entity executing the attack, Goal class describes goal of the attack, Attack mechanism class defines attack methodology, Scope class describes size and utility of the target, Automation level describes the automation level of the attack Evaluation of security status of the network is required for network security situational awareness. Network class has network operating system, users, roles, hardware components and services as its subclasses. Based on this taxonomy ontology has been developed to perceive network security status. Finally a framework, which uses this ontology as knowledgebase has been proposed. © 2014 IEEE.


Sharma J.P.,Doaba College | Sekhon S.S.,Doaba College | Sekhon S.S.,Guru Nanak Dev University
Bulletin of Materials Science | Year: 2013

The effect of addition of propylene carbonate (PC) and nano-sized fumed silica on the ionic conductivity behaviour of proton conducting polymer electrolytes containing different concentrations of hexafluorophosphoric acid (HPF6) in polyethylene oxide (PEO) has been studied. The addition of PC results in an increase in ionic conductivity, whereas the addition of nano-sized fumed silica improves mechanical strength of electrolytes along with a small increase in ionic conductivity. It was observed that the simultaneous addition of PC and fumed silica results in electrolytes with optimum value of ionic conductivity and other properties. © Indian Academy of Sciences.


Sharma J.P.,Doaba College | Yamada K.,Nihon University | Sekhon S.S.,Guru Nanak Dev University
Ionics | Year: 2012

The effect of the addition of propylene carbonate (PC) on the ion transport behaviour of nanocomposite polymer electrolytes having composition of polyethylene oxide-hexafluorophosphoric acid-fumed silica has been studied. The ionic conductivity of 6. 89 × 10 -4 S cm -1 at 298 K has been obtained for these electrolytes along with good mechanical and thermal properties. The variation of 1H NMR linewidth with temperature shows line narrowing at the glass transition and melting temperature of the electrolytes which suggests the onset of long-range ion translational motion. The increase in ionic conductivity with the addition of PC is related to the transformation of these electrolytes to the amorphous phase which has been supported by X-ray diffraction results. The polymer electrolytes are thermally stable up to around 498 K and hence are suitable for various applications. © 2011 Springer-Verlag.


Gill B.S.,Central University of Punjab | Kumar S.,Central University of Punjab | Navgeet,Doaba college
Molecular Biology Reports | Year: 2016

Evaluating anti-oxidant potential of Ganoderic acid A in STAT 3 pathway in Prostate cancer. Molecular docking and ADMET activities of different isoforms of ganoderic acid on STAT 3 pathway were performed by Maestro 9.6 (Schrödinger Inc). The ganoderic acid A is best-docked among isoforms which analyses the expression level of antioxidant and STAT 3 pathway in PC-3 cells. The receptor-based molecular docking reveals the best binding interaction of SH2 domain of STAT3 and ganoderic acid A with GScore (−6.134), kcal/mol, Lipophilic EvdW (−1.83), Electro (−1.1), Glide emodel (−31.857), H bond (1.98), MM-GBSA (−69.555). The molecular docking QikProp analyzed the absorption, distribution, metabolism, excretion, and toxicity (ADME/T). The ganoderic acid A is best-docked among isoforms which downregulates the expression of STAT 3 in PC-3 cells. Moreover, ganoderic acid A inhibits proliferation, viability, ROS, DPPH, and analyzed the expression of SOD1, SOD2, and SOD3 by Real time PCR in a PC-3 cell in a dose-dependent manner. Molecular docking revealed the mechanistic binding of Ganoderic acid A in STAT3 signaling, which inhibits the proliferation, viability, and ROS in PC-3 cells. © 2016 Springer Science+Business Media Dordrecht


Bhandari P.,Doaba College | Singh M.,Punjabi University
Procedia Computer Science | Year: 2016

As the computer network has evolved to provide the user many services, the attacks on these networks to disrupt the services and to gain access to resources has also evolved. New entities in form of services, hardware, network protocols etc. are being added to the network, which is leading to new ways to attack the network. The complexity of the system is increasing so fast that it is becoming increasingly difficult for network administrator to comprehend the situation and react in an appropriate manner. Situation becomes more complex as there is no uniform terminology. Though serious efforts in form of Common Vulnerability Enumeration (CVE), Common Weakness Enumeration (CWE), Common Attack Pattern Enumeration and Classification (CAPEC) etc. has been made, still a long way is to go. In this paper we have proposed a formal specification of the framework for network security situational awareness (NSSA) using ontological engineering approach. We have modeled a computer network by modeling its components i.e. hardware, software, services using ontology. Also vulnerabilities and attacks on these computers are modeled. We populate our ontology with various instances of vulnerabilities, CVSS scores, attacks and possible services in the network. Knowledge representation methods are used in order to provide Description Logic reasoning and inference over network security status concept. Secondly we propose an ontology based system which predicts probable attacks using inference and information provided by the environment. © 2016 The Authors. Published by Elsevier B.V.


Bhandari P.,Doaba College | Singh M.,Punjabi University
Proceedings - 6th International Advanced Computing Conference, IACC 2016 | Year: 2016

Computer networks are becoming more and more important because of variety of services being applied through them, so is the trend of increase of threats to these networks. Traditional approaches of network security like packet filtering, IDS and more advanced IPS suffer from various problems. E.g. These mechanisms are not aware of the resources they are protecting, these mechanisms are independent of the context of their application, their working is common to every kind of environment, these approaches do not adapt to the changing environment (configuration of the network and changing scenarios) on the run, these approaches do not take the holistic view of security situation. The concept of Network Security Situational awareness has been proposed to tackle the network security in a holistic manner. For holistic view of security biggest challenge for computing community is an efficient interoperability among heterogeneous data sources Ontologies have proved to play important role in resolving semantic heterogeneity by providing formalization of knowledge in a particular domain. Ontology represents the concepts of interest in a domain and the relations among them in a machine processable format. Separate ontologies may be developed for related domains and various ontologies may be integrated. Individual ontologies allow the development of ontology for one information source independently, hence making possible the addition of new and removal of obsolete information sources. This feature makes the application of ontology in areas where configuration of a system is continuously changing like in a computer network. In this paper we have implemented a tool OntoSecure, a semantic web based tool for network security status prediction. The effectiveness of this tool has been proved by considering various test cases. © 2016 IEEE.


PubMed | Central University of Punjab and Doaba college
Type: Journal Article | Journal: Molecular biology reports | Year: 2016

Evaluating anti-oxidant potential of Ganoderic acid A in STAT 3 pathway in Prostate cancer. Molecular docking and ADMET activities of different isoforms of ganoderic acid on STAT 3 pathway were performed by Maestro 9.6 (Schrdinger Inc). The ganoderic acid A is best-docked among isoforms which analyses the expression level of antioxidant and STAT 3 pathway in PC-3 cells. The receptor-based molecular docking reveals the best binding interaction of SH2 domain of STAT3 and ganoderic acid A with GScore (-6.134), kcal/mol, Lipophilic EvdW (-1.83), Electro (-1.1), Glide emodel (-31.857), H bond (1.98), MM-GBSA (-69.555). The molecular docking QikProp analyzed the absorption, distribution, metabolism, excretion, and toxicity (ADME/T). The ganoderic acid A is best-docked among isoforms which downregulates the expression of STAT 3 in PC-3 cells. Moreover, ganoderic acid A inhibits proliferation, viability, ROS, DPPH, and analyzed the expression of SOD1, SOD2, and SOD3 by Real time PCR in a PC-3 cell in a dose-dependent manner. Molecular docking revealed the mechanistic binding of Ganoderic acid A in STAT3 signaling, which inhibits the proliferation, viability, and ROS in PC-3 cells.

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